Poly (ε-caprolactone)/poly (N-vinyl-2-pyrrolidone) core–shell nanofibers loaded by multi-walled carbon nanotubes and 5-fluorouracil: an anticancer drug delivery system

Nasari, Mina; Semnani, Dariush; Hadjianfar, Mehdi; Amanpour, Saeid

doi:10.1007/s10853-020-04784-3

Cited by 35 publications

(14 citation statements)

References 51 publications

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“…Moreover, the incorporation of a drug onto the core, which in turn will be coated by the shell, could effectively control the drug's release profile and protect the drug from damage, offering a great advantage to this type of structure. [55,126,127]…”

Section: Coaxial Electrospinningmentioning

confidence: 99%

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Costa

Fangueiro

Ferreira

2022

Macromolecular Bioscience

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Recently, photodynamic therapy (PDT) has become a promising approach for the treatment of a broad range of diseases, including oncological and infectious diseases. This minimally invasive and localized therapy is based on the production of reactive oxygen species able to destroy cancer cells and inactivate pathogens by combining the use of photosensitizers (PSs), light, and molecular oxygen. To overcome the drawbacks of drug systemic administration, drug delivery systems (DDS) can be used to carrier the PSs, allowing higher therapeutic efficacy and minimal toxicological effects. Polymeric nanofibers produced by electrospinning emerged as powerful platforms for drug delivery applications. Electrospun nanofibers exhibit outstanding characteristics, such as large surface‐area‐to‐volume ratio associated with high drug loading, high porosity, flexibility, ability to incorporate and release a wide variety of therapeutic agents, biocompatibility, and biodegradability. Due to the versatility of this technique, fibers with different morphologies and functionalities, including drug release profile can be produced. The possibility of scalability makes electrospinning even more attractive for the development of DDS. This review aims to explore and show an up to date of the huge potential of electrospun nanofibers as DDS for different PDT applications and discuss the opportunities and challenges in this field.

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Section: Coaxial Electrospinningmentioning

confidence: 99%

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Costa

Fangueiro

Ferreira

2022

Macromolecular Bioscience

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“…Localized micelle release was complemented by targeting ligands which promoted micelle endocytosis [ 127 ]. The addition of nanostructures was also used to improve tensile and drug releasing properties of PVP-based NFs [ 128 ]. While PVP core was used to encapsulate unstable 5-fluorouracil (5FU), the addition of PCL and multi-walled carbon nanotubes (MWCNT) to the PVP shell resulted in improved sustainable drug release and mechanical properties.…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

Nanofiber Carriers of Therapeutic Load: Current Trends

Jarak

Silva

Domingues

et al. 2022

IJMS

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The fast advancement in nanotechnology has prompted the improvement of numerous methods for the creation of various nanoscale composites of which nanofibers have gotten extensive consideration. Nanofibers are polymeric/composite fibers which have a nanoscale diameter. They vary in porous structure and have an extensive area. Material choice is of crucial importance for the assembly of nanofibers and their function as efficient drug and biomedicine carriers. A broad scope of active pharmaceutical ingredients can be incorporated within the nanofibers or bound to their surface. The ability to deliver small molecular drugs such as antibiotics or anticancer medications, proteins, peptides, cells, DNA and RNAs has led to the biomedical application in disease therapy and tissue engineering. Although nanofibers have shown incredible potential for drug and biomedicine applications, there are still difficulties which should be resolved before they can be utilized in clinical practice. This review intends to give an outline of the recent advances in nanofibers, contemplating the preparation methods, the therapeutic loading and release and the various therapeutic applications.

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“…MWCNTs conjugated with PEI, an antiviral drug ribavirin ( Figure 4 ) and the pearl gentian grouper nervous necrosis virus (PGNNV)-specific nanobody showed an increasing distribution in PGNNV-infected cells, powerful anti-PGNNV ability both in vitro and in vivo and such formulations can be an effective tool for virus-induced central nervous system disease targeted therapy [ 285 ]. PCL/poly( N -vinyl-2-pyrrolidone) (PVP) core-shell nanofibers showing mean diameter 300–400 nm and containing MWCNTs and 5-FU loaded in the core of these nanofibers showed sustained and prolonged drug release (up to 85% after 528 h) and cytotoxicity against HeLa cells (50.35% after 72 h), suggesting that this drug delivery system can be applied in post-surgical delivery of anticancer drugs [ 286 ].…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

2021

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Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

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Poly (ε-caprolactone)/poly (N-vinyl-2-pyrrolidone) core–shell nanofibers loaded by multi-walled carbon nanotubes and 5-fluorouracil: an anticancer drug delivery system

Cited by 35 publications

References 51 publications

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Drug Delivery Systems for Photodynamic Therapy: The Potentiality and Versatility of Electrospun Nanofibers

Nanofiber Carriers of Therapeutic Load: Current Trends

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

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