Polyacetylenes of Marine Origin: Chemistry and Bioactivity

Zhou, Zhihao; Menna, Marialuisa; Cai, Yuanfeng; Guo, Yue‐Wei

doi:10.1021/cr4006507

Cited by 138 publications

(90 citation statements)

References 316 publications

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“…Currently, there are 10 FDA-approved marine-derived pharmaceutical drugs, together with 30 potential candidates for application in a number of disease areas that are in different stages of clinical trials (Phase I, II and III) Figure 1 [5]. A number of reviews have also detailed the biologically active natural products that are sourced from marine organisms [6][7][8][9][10], highlighting marine organisms as an important resource for the production of new and unique compounds with potential medicinal value. Many of the compounds represented in Figure 1 have been isolated from sponges, ascidians and cyanobacteria.…”

Section: Introductionmentioning

confidence: 99%

Natural Products of Marine Macroalgae from South Eastern Australia, with Emphasis on the Port Phillip Bay and Heads Regions of Victoria

et al. 2020

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Marine macroalgae occurring in the south eastern region of Victoria, Australia, consisting of Port Phillip Bay and the heads entering the bay, is the focus of this review. This area is home to approximately 200 different species of macroalgae, representing the three major phyla of the green algae (Chlorophyta), brown algae (Ochrophyta) and the red algae (Rhodophyta), respectively. Over almost 50 years, the species of macroalgae associated and occurring within this area have resulted in the identification of a number of different types of secondary metabolites including terpenoids, sterols/steroids, phenolic acids, phenols, lipids/polyenes, pheromones, xanthophylls and phloroglucinols. Many of these compounds have subsequently displayed a variety of bioactivities. A systematic description of the compound classes and their associated bioactivities from marine macroalgae found within this region is presented.

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Section: Introductionmentioning

confidence: 99%

Natural Products of Marine Macroalgae from South Eastern Australia, with Emphasis on the Port Phillip Bay and Heads Regions of Victoria

et al. 2020

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“…Numerous NPs with novel chemical skeletons and intriguing biological activities have been isolated from the marine organisms, including plants, animals, microorganisms, and so on [1,2,3]. Marine-derived microorganisms, as a huge resource for the discovery of active NPs, have attracted widespread attention [4,5,6,7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164

et al. 2018

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Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 μM, respectively.

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“…Cyclic ether moieties are of widespread appearance in a number of natural products exhibiting important biological properties such as C ‐glycosides or nucleosides, the potent antitumoral agents annonaceous acetogenins, the polyether antibiotics, some macrolide antibiotics, a number of marine natural products and toxins . Thus, stereoselective approaches to these substituted heterocyclic derivatives are of huge interest and continue to attract considerable attention of the synthetic community .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Medium‐Sized 2,ω‐cis‐Disubstituted Cyclic Ethers by Reductive Cyclization of Hydroxy Ketones

et al. 2016

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The synthesis of 7-, 8-and 9-membered cyclic ethers isolaurepan, lauthisan and obtusan was achieved through the cisstereoselective TMSOTf/Et 3 SiH promoted reductive cyclization of the corresponding saturated hydroxy ketones, available in three steps from commercial starting materials: oxirane opening with lithium acetylide, Rh-catalyzed conjugate addition of the terminal alkynes to the corresponding unsaturated ketones and triple bond hydrogenation.

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Polyacetylenes of Marine Origin: Chemistry and Bioactivity

Cited by 138 publications

References 316 publications

Natural Products of Marine Macroalgae from South Eastern Australia, with Emphasis on the Port Phillip Bay and Heads Regions of Victoria

Natural Products of Marine Macroalgae from South Eastern Australia, with Emphasis on the Port Phillip Bay and Heads Regions of Victoria

New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164

Synthesis of Medium‐Sized 2,ω‐cis‐Disubstituted Cyclic Ethers by Reductive Cyclization of Hydroxy Ketones

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