Polyacrylic acid-coated cerium oxide nanoparticles: An oxidase mimic applied for colorimetric assay to organophosphorus pesticides

Shixiang, Zhang; Xue, Shi-Fan; Deng, Jingjing; Zhang, Min; Shi, Guoyue; Zhou, Tianshu

doi:10.1016/j.bios.2016.05.040

Cited by 94 publications

(41 citation statements)

References 22 publications

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“…[31] Their later study showed that nanoceria conjugated with Protein G were able to immobilize antibodies, enabling the identification of cancer biomarkers at neutral pH conditions. [32] Color indicators and oxygen sources Additionally, nanoceria could be used as color indicators and oxygen sources for the measurements of nucleic acids, [75] glucose, [76] organophosphorus pesticides, [24] dopamine [51] and glutamate. [77] IláKim et al [75] reported an ultrafast colorimetric assay for nucleic acids detection based on nanoceria.…”

Section: Immunoassaysmentioning

confidence: 99%

“…[17][18][19] In previous studies, ceria nanoparticles (nanoceria) and nanoceria-supported materials have been reported to have multi-enzyme mimetic activities like those of superoxide oxidase, [20,21] catalase [22,23] and oxidase. [24,25] That means nanoceria have enzymatic activities to catalyze the scavenging of reactive oxygen species (ROS). ROS are highly reactive and unstable compounds, with the ability to capture electrons from cellular macromolecules to damage proteins and DNA and to modify membrane fatty acids, thus impairing major cell functions.…”

Section: Introductionmentioning

confidence: 99%

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Ceria Nanoparticles as Enzyme Mimetics

Wang

Zhang

et al. 2017

Chin. J. Chem.

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In the past decades, enzyme mimetics based on ceria nanoparticles (nanoceria) have been developed as potential substitutes for nature enzymes. The mixed valence states of cerium and the patterns of oxygen vacancies on crystal planes result in different enzyme mimetic activities. In this review we survey the bio-applications of nanoceria-based enzyme mimetics as well as the underlying mechanisms. Factors influencing the enzyme mimetic activities and future perspective of nanoceria-based enzyme mimetics are also addressed.

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Section: Immunoassaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ceria Nanoparticles as Enzyme Mimetics

Wang

Zhang

et al. 2017

Chin. J. Chem.

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“…The AuNP/ITO electrode was further characterized using cyclic voltammetry. The electrochemical measurements were performed in 0.4 M KNO 3 solution containing 1 mM K 3 Fe(CN) 6 . The redox couple of Fe(CN) 6 4À /Fe(CN) 6…”

Section: Resultsmentioning

confidence: 99%

“…[1,2] Previous research has demonstrated that these nanozymes show significant advantages over natural enzymes including simple preparation processes, low costs, high stability, and excellent catalytic activity. [3] These advantages lead to applications such as colorimetric diagnosis, [4][5][6] electrochemical analysis, [7][8][9][10] and therapy. [11] The catalytic properties of nanozymes can be diversified by the morphology and surface of nanomaterials such as metal nanoparticles, [12,13] metal oxide nanostructures, [14][15][16] and carbon based materials.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Electrochemical Determination of Norepinephrine Using Poly Acrylic Acid‐Coated Nanoceria

Son

Tran

et al. 2019

ChemElectroChem

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We synthesized a poly acrylic acid‐coated nanoceria (PNC) and developed colorimetric and electrochemical methods for determining norepinephrine (NE) using 3,3′‐5,5′‐tetramethylbenzidine (TMB) as a redox marker. The PNC was the nanozyme, an oxidase mimic with effective catalytic activity. During the reaction, PNC oxidized the TMB (TMBox) in the absence of hydrogen peroxide. The product not only showed visible color change from transparent to blue, but also generated an electrochemical current. NE reduced the TMBox, and the color changed from blue back to colorless. As a result, we were able to determine the NE concentration using both colorimetric and electrochemical methods. The colorimetric determination showed a linearity from 0.2 to 19 μM, with an estimated detection limit of 126 nM. For point‐of‐care applications, NE concentration was also detected on paper‐based devices. NE was detected from 1.0 to 25 μM with the detection limit of 863 nM. For electrochemical detection, gold nanoparticles were deposited on indium tin oxide glass as the working electrode. NE ranged from 0.1 to 300 μM, with an estimated detection limit of 66 nM, which was lower than for the colorimetric methods. Spike recovery values for NE in human plasma samples ranged from 93.4 to 108 %. These results demonstrate that using PNC nanozymes for electrochemical detection is a promising assay to determine NE.

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“…A typical example is the detection applications for food antioxidants (Jia et al., ). In contrast to H 2 O 2 ‐generating enzymes, natural enzymes that produce reductive products, such alkaline phosphatase and acetylcholinesterase (AChE) (Huang, Sun et al., ; Zhang, Xue et al., ), can be used to construct multienzyme detection systems (Figure C, recognition 6 and 7).…”

Section: Principles Of Detection Using Enzyme‐mimetic Nanomaterialsmentioning

confidence: 99%

Development of Nanozymes for Food Quality and Safety Detection: Principles and Recent Applications

Huang

Sun

et al. 2019

Comp Rev Food Sci Food Safe

146

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The public concerns about agrifood safety call for innovative and reformative analytical techniques to meet the inspection requirements of high sensitivity, specificity, and reproducibility. Enzyme‐mimetic nanomaterials or nanozymes, which combine enzyme‐like properties with nanoscale features, emerge as an excellent tool for quality and safety detection in the agrifood sector, due to not only their robust capacity in detection but also their attraction in future‐oriented exploitations. However, in‐depth understanding about the fundamental principles of nanozymes for food quality and safety detection remains limited, which makes their applications largely empirical. This review provides a comprehensive overview of the principles, designs, and applications of nanozyme‐based detection technique in the agrifood industry. The discussion mainly involves three mimicking types, that is, peroxidase, oxidase, and catalase‐like nanozymes, capable of detecting major agrifood analytes. The current principles and strategies are classified and then discussed in details through discriminating the roles of nanozymes in diverse detection platforms. Thereafter, recent applications of nanozymes in detecting various endogenous ingredients and exogenous contaminants in foods are reviewed, and the outlook of profound developments are explained. Evidenced by the increasing publications, nanozyme‐based detection techniques are narrowing the gap to practical‐oriented food analytical methods, while some challenges in optimization of nanozymes, diversification of recognition‐to‐signal manners, and sustainability of methodology need to conquer in the future.

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Polyacrylic acid-coated cerium oxide nanoparticles: An oxidase mimic applied for colorimetric assay to organophosphorus pesticides

Cited by 94 publications

References 22 publications

Ceria Nanoparticles as Enzyme Mimetics

Ceria Nanoparticles as Enzyme Mimetics

Highly Sensitive Electrochemical Determination of Norepinephrine Using Poly Acrylic Acid‐Coated Nanoceria

Development of Nanozymes for Food Quality and Safety Detection: Principles and Recent Applications

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