Polyamide-based pH and temperature-responsive hydrogels: Synthesis and physicochemical characterization

Ho, Duy Khiet; Nguyen, Dang Tri; Thambi, Thavasyappan; Lee, Sang Soo; Huynh, Dai Phu

doi:10.1007/s10965-018-1666-4

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…The PCEC triblock polymer itself can have thermosensitivity, which has been reported in recent publications. 37,38 The LCST of the PCEC hydrogel decreases as the chain length of hydrophobic blocks increases, indicating that the formation of micellar crosslinking becomes easier when longer hydrophobic blocks exist. 37 Similarly, addition of fibers provides more hydrophobic binding sites for micelles, and thus, the crosslinking network becomes easier to form.…”

Section: Discussionmentioning

confidence: 99%

“…37,38 The LCST of the PCEC hydrogel decreases as the chain length of hydrophobic blocks increases, indicating that the formation of micellar crosslinking becomes easier when longer hydrophobic blocks exist. 37 Similarly, addition of fibers provides more hydrophobic binding sites for micelles, and thus, the crosslinking network becomes easier to form. Therefore, as the fiber content increases, the LCST of hydrogels will keep decreasing and disappear until a critical fiber content is reached.…”

Section: Discussionmentioning

confidence: 99%

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Surface Modification of Nanofibers by Physical Adsorption of Fiber-Homologous Amphiphilic Copolymers and Nanofiber-Reinforced Hydrogels with Excellent Tissue Adhesion

Zhong

Li²,

Zhao

et al. 2021

ACS Biomater. Sci. Eng.

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Herein, we report a simple approach to modify hydrophobic PCL nanofibers by adsorption of a fiber-homologous amphiphilic triblock copolymer (PCL-b-PEG-b-PCL, PCEC). The modified PCL nanofibers were then utilized to reinforce a physical hydrogel, which was formed by micellar crosslinking of the same PCEC triblock copolymer. Therefore, the copolymer played a dual role in not only dispersing and stabilizing nanofibers but also additionally providing a framework for the hydrogel matrix. The mechanical strength of the hydrogel was significantly enhanced by addition of the modified PCL nanofibers, and the gel modulus can be tuned by varying the concentration of the copolymer and nanofibers. The effect of nanofiber size and content on the mechanical properties of the hydrogel matrices was studied. Different from hydrogel composites that were reinforced by 2D fiber meshes or 3D woven fiber networks, this free fiber-reinforced hydrogel can be readily injected to adapt to the environmental shape and self-heal. The hydrogel composites showed superior tissue adhesion properties compared to the commercially available fibrin glue, especially in muscle adhesion. Due to its injectable and self-healing properties, this nanofiber-reinforced hydrogel may have great potential as a new type of tissue sealant.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surface Modification of Nanofibers by Physical Adsorption of Fiber-Homologous Amphiphilic Copolymers and Nanofiber-Reinforced Hydrogels with Excellent Tissue Adhesion

Zhong

Li²,

Zhao

et al. 2021

ACS Biomater. Sci. Eng.

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“…Smart hydrogels such as dual sensitive pentablock copolymers were synthesized through chemical conjugation between thermosensitive segment, poly(ε-caprolactone)- b -poly (ethylene glycol)- b -poly(ε-caprolactone) (PCL- b -PEG-bPCL), and pH-responsive polyamide [ 26 ]. The pentablock copolymers showed gelation at biological environment (pH 7.4, 37 °C), a controlled degradation rate and hence controlled release of the entrapped compound.…”

Section: Stimuli-sensitive Hydrogelsmentioning

confidence: 99%

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

et al. 2021

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The popularity of hydrogels as biomaterials lies in their tunable physical properties, ability to encapsulate small molecules and macromolecular drugs, water holding capacity, flexibility, and controllable degradability. Functionalization strategies to overcome the deficiencies of conventional hydrogels and expand the role of advanced hydrogels such as DNA hydrogels are extensively discussed in this review. Different types of cross-linking techniques, materials utilized, procedures, advantages, and disadvantages covering hydrogels are tabulated. The application of hydrogels, particularly in buccal, oral, vaginal, and transdermal drug delivery systems, are described. The review also focuses on composite hydrogels with enhanced properties that are being developed to meet the diverse demand of wound dressing materials. The unique advantages of hydrogel nanoparticles in targeted and intracellular delivery of various therapeutic agents are explained. Furthermore, different types of hydrogel-based materials utilized for tissue engineering applications and fabrication of contact lens are discussed. The article also provides an overview of selected examples of commercial products launched particularly in the area of oral and ocular drug delivery systems and wound dressing materials. Hydrogels can be prepared with a wide variety of properties, achieving biostable, bioresorbable, and biodegradable polymer matrices, whose mechanical properties and degree of swelling are tailored with a specific application. These unique features give them a promising future in the fields of drug delivery systems and applied biomedicine.

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“…The pentablock copolymer was easily soluble at 20 wt.% and resulted in a stable hydrogel at pH 7.4 and a temperature of 37 °C (physiological region). In addition, the sol-to-gel transition of the pentablock copolymers could be changed through altering the polyamide to PCL/PEG ratios [11]. Conjugation of a therapeutic agent to the polymer results in a drug-polymer conjugate with enhanced pharmacokinetic/pharmacodynamic properties such as increased plasma half-life due to prolonged plasma circulation, protection of drugs from proteolytic enzymes, decreased immunogenic response, enhanced stability (proteins and peptides), enhanced solubility of low molecular weight drugs and the possibility for targeted delivery.…”

Section: Polyamide Polymers Used In Drug Deliverymentioning

confidence: 99%

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery

Boddu

Bhagav

Karla

et al. 2021

JFB

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Polymers have always played a critical role in the development of novel drug delivery systems by providing the sustained, controlled and targeted release of both hydrophobic and hydrophilic drugs. Among the different polymers, polyamides or poly(amino acid)s exhibit distinct features such as good biocompatibility, slow degradability and flexible physicochemical modification. The degradation rates of poly(amino acid)s are influenced by the hydrophilicity of the amino acids that make up the polymer. Poly(amino acid)s are extensively used in the formulation of chemotherapeutics to achieve selective delivery for an appropriate duration of time in order to lessen the drug-related side effects and increase the anti-tumor efficacy. This review highlights various poly(amino acid) polymers used in drug delivery along with new developments in their utility. A thorough discussion on anticancer agents incorporated into poly(amino acid) micellar systems that are under clinical evaluation is included.

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Polyamide-based pH and temperature-responsive hydrogels: Synthesis and physicochemical characterization

Cited by 12 publications

References 31 publications

Surface Modification of Nanofibers by Physical Adsorption of Fiber-Homologous Amphiphilic Copolymers and Nanofiber-Reinforced Hydrogels with Excellent Tissue Adhesion

Surface Modification of Nanofibers by Physical Adsorption of Fiber-Homologous Amphiphilic Copolymers and Nanofiber-Reinforced Hydrogels with Excellent Tissue Adhesion

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management

Polyamide/Poly(Amino Acid) Polymers for Drug Delivery

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