Polyamines as biological markers in malignant lymphomas

Thyss, Antoine; Milano, Gérard; Caldani, C.; Lesbats, G; Schneider, M.; Lalanne, C.M.

doi:10.1016/0277-5379(82)90205-x

Cited by 9 publications

(2 citation statements)

References 14 publications

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“…Polyamine metabolism upregulation through oncogenic MYC is a common metabolic irregularity in aggressive cancers, including lymphomas. 11 , 23 , 24 Specifically, MYC is an established transcriptional regulator of PMEs, including ODC1, SRM, and SMS, that yield non-acetylated polyamines. The catabolism of polyamines to their acetylated derivatives is mediated by spermidine/spermine N1-acetyltransferase 1 (SAT1), which is responsive to intra-cellular polyamine levels.…”

Section: Discussionmentioning

confidence: 99%

A polyamine-centric, blood-based metabolite panel predictive of poor response to CAR-T cell therapy in large B cell lymphoma

Fahrmann

Saini

Chang

et al. 2022

Cell Reports Medicine

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Section: Discussionmentioning

confidence: 99%

A polyamine-centric, blood-based metabolite panel predictive of poor response to CAR-T cell therapy in large B cell lymphoma

Fahrmann

Saini

Chang

et al. 2022

Cell Reports Medicine

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“…As noted by the authors, spermidine and spermine indices determined in rather high concentrations among the patients observed, turned out to be more informative. A noteworthy fact is that shifts in the polyamine content in the urine of patients suffering from various forms of lymphomas can serve as additional diagnostic criteria in "Hodgkin's" vs. "non-Hodgkin's" lymphomas [Thyss A et al, 1982]. Thus, in Hodgkin's disease, certain patterns of specific polyamine shift in urine were not detected.…”

Section: Role Of Aliphatic Polyamines In Certain Malignant Neoplasmsmentioning

confidence: 99%

Selective Administration of Polyamine-Deficient and Polyamine-Free Diets to Cancer Patients

Avagyan,

Zilfyan,

Muradyan

2023

NAMJ

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Aliphatic polyamines (putrescin, spermidine, spermine and cadaverine) play an important role in the induction of neoplastic processes leading to cell malignancy. In malignantly transformed cells, a high level of aliphatic polyamines has been observed, which ensures their steady anaplastic growth. This is precisely why elevated levels of the aforementioned polyamines are considered as diagnostic and prognostic criteria for a wide range of oncological diseases. In several developed countries, cancer patients are advised to follow a low-polyamine diet, including specifically those food products that are identified in the general nutrient registry as having low levels of aliphatic polyamines. However, when recommending such a diet, many researchers did not pay attention to the fact that in different food products, the ratio of polyamine levels often varies within very wide limits. Therefore, as some researchers report a polyamine-deficient diet prescribed to cancer patients is not always effective. We analyzed various literary sources and identified products that do not contain polyamines or contain them in very low quantities. Based on the analysis of available literary data, when patients are admitted to oncology clinics, along with generally accepted laboratory diagnostic criteria, it is necessary to include diagnostic indicators for determining the levels of aliphatic polyamines in erythrocytes and blood plasma, including putrescine, spermidine, spermine, and cadaverine. Due to this approach, oncologists and nutritionists may have a real opportunity to prescribe a selective polyamine-deficient diet. For patients with advanced cancer, we recommend the use of a polyamine-free diet instead of a polyamine-deficient one.

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