Polyaminoacid Based Core@shell Nanocarriers of 5-Fluorouracil: Synthesis, Properties and Theranostics Application

Szczęch, Marta; Hinz, Alicja; Łopuszyńska, Natalia; Bzowska, Monika; Węglarz, Władysław P.; Szczepanowicz, Krzysztof

doi:10.3390/ijms222312762

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…Such an SNR was enough to reasonably visualize the distribution of fluorine in the analyzed sample, confirming the possibility of detecting Nafion-based theranostic nanocapsules using 19 F-MRI. A different approach to theranostic polymeric nanoparticle detection was proposed by Szczęch et al [178]. In the latter study, the drug itself, 5-fluorouracil (5-FU), was also used as the contrast moiety as it contains a fluorine atom.…”

Section: Nanocarriers With Direct Detection Casmentioning

confidence: 99%

Contrasting Properties of Polymeric Nanocarriers for MRI-Guided Drug Delivery

Łopuszyńska

Węglarz

2023

Nanomaterials

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Poor pharmacokinetics and low aqueous solubility combined with rapid clearance from the circulation of drugs result in their limited effectiveness and generally high therapeutic doses. The use of nanocarriers for drug delivery can prevent the rapid degradation of the drug, leading to its increased half-life. It can also improve the solubility and stability of drugs, advance their distribution and targeting, ensure a sustained release, and reduce drug resistance by delivering multiple therapeutic agents simultaneously. Furthermore, nanotechnology enables the combination of therapeutics with biomedical imaging agents and other treatment modalities to overcome the challenges of disease diagnosis and therapy. Such an approach is referred to as “theranostics” and aims to offer a more patient-specific approach through the observation of the distribution of contrast agents that are linked to therapeutics. The purpose of this paper is to present the recent scientific reports on polymeric nanocarriers for MRI-guided drug delivery. Polymeric nanocarriers are a very broad and versatile group of materials for drug delivery, providing high loading capacities, improved pharmacokinetics, and biocompatibility. The main focus was on the contrasting properties of proposed polymeric nanocarriers, which can be categorized into three main groups: polymeric nanocarriers (1) with relaxation-type contrast agents, (2) with chemical exchange saturation transfer (CEST) properties, and (3) with direct detection contrast agents based on fluorinated compounds. The importance of this aspect tends to be downplayed, despite its being essential for the successful design of applicable theranostic nanocarriers for image-guided drug delivery. If available, cytotoxicity and therapeutic effects were also summarized.

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Section: Nanocarriers With Direct Detection Casmentioning

confidence: 99%

Contrasting Properties of Polymeric Nanocarriers for MRI-Guided Drug Delivery

Łopuszyńska

Węglarz

2023

Nanomaterials

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“…Fluorine is substituted for hydrogen in the C-5 position of 5-FU, making it an analog of uracil (Fig. 3) [47]. Using the exact accelerated transport mechanism as uracil quickly penetrates the cell.…”

Section: Selectivity Index Of 5-fluorouracilmentioning

confidence: 99%

Assessment of Alpha-fetoprotein levels and the effect of 5- Fluorouracil on Cytotoxicity of HepG2 cell line

Alnakib

Abdel-Hamid

Senduny

et al. 2022

Alfarama Journal of Basic & Applied Sciences

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Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide nowadays. In Egypt, the cancer is frequently discovered at an advanced stage, at which no therapy, even surgery, is successful. Early detection of the disease is critical because it enables the patients to be treated prior to enlarging or metastasizing to distant organs. A tumor marker is a serological agent whose blood level may indicate the existence of the tumor in the early stages. The gold standard and more reliable biomarkers for HCC is alpha-fetoprotein (AFP). Aim of the study: To determine the cytotoxicity and Selectivity index of 5-Fluorouracil in HepG2 and WI-38 cell lines by the methyl thiazole tetrazolium (MTT) assay and assess alpha-fetoprotein (AFP) levels as a tumor marker in the progression of HCC. Material and Methods: HepG2 and WI-38 cells were incubated with different concentrations of 5-Fluorouracil as a standard chemotherapy drug. The half-maximal inhibitory concentration (IC50) values were determined the methyl thiazole tetrazolium (MTT) for 5-Fluorouracil. Results: IC50 values for HepG2 and WI-38 were found for 5-Fluorouracil (32.533±0.777μM and 63.400±0.624μM ), respectively. Moreover, the selective index value of 5-Fluorouracil was (1.949±0.027μM). The AFP levels in the HepG2 cell line treated with 5-Fluorouracil were measured. We found significant inhibition in AFP levels after treating HepG 2 cell lines by 5-Fluorouracil. Conclusion: The change in AFP levels following chemotherapy with 5-fluorouracil is beneficial for predicting treatment response in the HepG-2 cell line.

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“…[15][16][17] The biocompatibility, biodegradability and selfassembly behavior of poly(amino acid)s make them have a very wide application prospect in controlled drug release systems. 18 In addition, poly(amino acid)s exhibit different characteristics from ordinary macromolecules due to the existence of secondary structures (a-helix and b-fold). 19 There are many easily reactive functional groups such as amino and carboxyl groups on the side chain, which can be further modified with drugs or bioactive molecules to prepare a variety of nano drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%