Polyampholyte acrylic latexes for tablet coating applications

Abstract

Polyampholyte latexes can exist within a certain pH range as low-viscosity aqueous dispersions, while upon a pH shift to the vicinity of the isoelectric point they undergo ionic coacervation. Three classes of coacervation latexes were synthesized and evaluated for their suitability for use in tablet coating applications. Pharmaceutical tablet coatings are commonly based on hydroxypropyl methyl cellulose, poly(vinyl alcohol), and acrylic polymers. Because of the high viscosity of their aqueous solutions, and to the consequent required low concentrations of the tablet coating polymers in the coating solutions to enable sufficiently low viscosity for effective spray application, the current commercial pharmaceutical tablet coating technology requires the removal of large amounts of water during the manufacturing process. In this work, films prepared from high-solids, low-viscosity coacervated acrylic latexes showed good hardness, very low tackiness, an excellent combination of optical properties, and very low water vapor permeability. V C 2013 Wiley Periodicals, Inc. J.Appl. Polym. Sci. 2014, 131, 40049. Polyampholytes have found application in areas such as lithographic film, 19 drag reduction, 20 membranes, 21 water-based coatings, 22 papermaking, 23 skin care, 24 and controlled drug release. 25 In addition, polyampholyte latexes have been developed for various types of fast-setting industrial coatings (on cement, metal, glass, wood, and other surfaces). 10,26 Additional Supporting Information may be found in the online version of this article.

Nondestructive Characterization of Drying Processes of Colloidal Droplets and Latex Coats Using Optical Coherence Tomography

“…A latex is usually synthesized by the emulsion polymerization procedure [31,34]. Thanks to their ability of film formation, latexes can be used in application including the binder in waterborne paints [35], waterborne pressure-sensitive adhesives [36], inkjet printing [37,38], sunscreen [39], paper coating [40,41], drug tablet coating [42,43], carpet backing [44], and evaporative lithography [45][46][47].…”

Polyampholyte Hydrogels in Biomedical Applications

“…Another application of adding polyampholytes to drug delivery vehicles is based on their strong water holding capacity. Polyampholyte acrylic latexes were incorporated into drug tablet coatings to minimize the amount of water removed from the drugs during the tablet drying step [63]. During the optimization of this approach, Ladika et al focused on finding a polymer solution with similar viscosity to the industry standard, that contained a much higher concentration of solids.…”

Synthesis of Water‐Soluble Oligomers From Imidazole, Ethyleneglycol Diglycidyl Ether, and Methacrylic Acid. An Insight Into the Chemical Structure, Aggregation Behavior and Formation of Hollow Spheres

“…These functionalized polymers have found application in areas such as manufacture of lithographic films, drag reduction, ion adsorption, membrane‐based bioseparations, cryoprotection, manufacture of water‐based coatings, papermaking, skin care, controlled drug release, and tissue engineering …”