Polyarthritis and positive LE preparation in sickle hemoglobinopathies: A report of two cases

White, Larry E.; Reeves, Jerry D.

doi:10.1016/s0022-3476(79)80296-6

Cited by 20 publications

(15 citation statements)

References 9 publications

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“…In this review, 16 patients (36%) met at least one of these criteria. 3,5,6,9,10,12,15,[17][18][19][21][22][23][24] However, hematological laboratory evaluation is not very specific and, separately, it does not contribute to the clinical suspicion of coexistence of both diseases. In most cases, SLE anemia is initially normocytic and normochromic and, if persistent, evolves into microcytosis and hypochromia.…”

Section: Hematological Manifestationsmentioning

confidence: 99%

Coexisting systemic lupus erythematosus and sickle cell disease: Case report and literature review

Robazzi

Alves

Abreu

et al. 2015

Revista Brasileira de Reumatologia (English Edition)

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r e v b r a s r e u m a t o l . 2 0 1 5;5 5(1):68-74 REVISTA BRASILEIRA DE REUMATOLOGIA w w w . r e u m a t o l o g i a . c o m . b r Sickle cell disease Systemic lupus erythematosus Hemoglobinopathies a b s t r a c t Objective: To report a case of coexisting systemic lupus erythematosus (SLE) and sickle cell disease (SCD) with a review of the literature on the topic.Methodology: Case report and literature review of the association between SLE and SCD through scientific articles in health sciences databases, such as LILACS, MEDLINE/Pubmed and Scielo, until May 2012. Descriptors used: 1. Sickle cell anemia; 2. Sickle cell disease; 3. Systemic lupus erythematosus; 4. Hemoglobinopathies. Results: The authors describe an association between SLE and SS hemoglobinopathy in an eight-year-old female patient presentingarticular, hematologic and neuropsychiatric manifestations during clinical evolution. Forty-five cases of association between SLE and SCD are described in literature, mostly adults (62.2%), women (78%) and with the SS phenotype in 78% of the cases, and diverse clinical manifestations. Compared with our patient, articular, hematologic and neuropsychiatric manifestations were present in 76%, 36% and 27% of the cases, respectively.Conclusion: SLE and SCD are chronic diseases that have several clinical and laboratory findings in common, meaning difficult diagnosis and difficulty in finding the correct treatment.Although the association between these diseases is not common, it is described in literature, so it is imperative that physicians who treat such diseases be alert to this possibility. Coexistência de lúpus eritematoso sistêmico e doença falciforme: relato de caso e revisão da literaturaPalavras-chave: Anemia falciforme Doença falciforme r e s u m o Objetivo: relatar um caso de coexistência de lúpus eritematoso sistêmico (LES) e doença falciforme (DF) com revisão da literatura sobre o tema. Metodologia: relato de caso e pesquisa da associação entre LES e DF na literatura, através de artigos científicos nas bases de dados de ciências da saúde, como LILACS, MEDLINE/Pubmed r e v b r a s r e u m a t o l . 2 0 1 5;5 5(1):68-74 69 Lúpus eritematoso sistêmico Hemoglobinopatias e Scielo, até maio de 2012.Descritores utilizados: 1. anemia falciforme; 2. doença falciforme; 3. lúpus eritematoso sistêmico; 4. hemoglobinopatias. Resultados: os autores descrevem a associação de LES e hemoglobinopatia SS em paciente do sexo feminino, oito anos, apresentando manifestaç ões articulares, hematológicas e neuropsiquiátricas durante a sua evolução clínica. Na literatura são descritos 45 casos de associação entre LES e DF, sendo a maioria em mulheres (78%) adultas (62,2%), apresentando fenótipo SS em 78% dos casos e com manifestaç ões clínicas variadas. Comparando com a nossa paciente, manifestaç ões articulares, hematológicas e neuropsiquiátricas, estiveram presentes em 76%, 36% e 27% dos casos, respectivamente. Conclusões: LES e DF são doenças crônicas que apresentam diversos achados clínicos e laboratoriais em comum, implica...

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Section: Hematological Manifestationsmentioning

confidence: 99%

Coexisting systemic lupus erythematosus and sickle cell disease: Case report and literature review

Robazzi

Alves

Abreu

et al. 2015

Revista Brasileira de Reumatologia (English Edition)

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show abstract

“…Nesta revisão 16 pacientes (36%) preenchiam pelo menos um desses critérios. 3,5,6,9,10,12,15,[17][18][19][21][22][23][24] Contudo, a avaliação laboratorial hematológica é pouco específica, não contribuindo isoladamente para a suspeita clínica da coexistência de ambas as doenç as.…”

Section: Desordens Hematológicasunclassified

“…30 Na tabela 1, observa-se que 12 pacientes (27%) com LES e DF possuíam desordens neuropsiquiátricas, incluindo convulsões, psicose, distúrbios cognitivos e acidentes vasculares cerebrais e apenas dois pacientes não possuíam fenótipo SS. [10][11][12]14,16,17,22,23,31 Presumivelmente, indivíduos portadores de ambas as doenç as, particularmente de fenótipo SS, possuem probabilidade maior em desenvolver doença cerebrovascular. Contudo, para um tratamento efetivo, é imprescindível que se identifique a etiologia da mesma.…”

Section: Desordens Neuropsiquiátricasunclassified

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Coexistência de lúpus eritematoso sistêmico e doença falciforme: relato de caso e revisão da literatura

Robazzi

Alves

Abreu

et al. 2015

Revista Brasileira de Reumatologia

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“…This may suggest an etiopathological link between these two phenomena. Coexistence of SCD and SLE has been reported by several authors, and due to their overlapping clinical features, making the diagnosis of CTD in the presence of SCD is somewhat difficult [2,4,[9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory characteristics of patients with sickle-cell and autoimmune/connective tissue diseases

2010

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Patients with sickle-cell disease who develop autoimmune connective tissue disorders can present with similar clinical manifestations and/or complications making them indistinguishable. We report here a single-institution study on a cohort of 24 patients, with the above combination. The results suggest that there is often a significant delay in making the second diagnosis because of the overlapping clinical profile. It is emphasized that the clinician should be aware of and vigilant about such cases and should diligently follow up such cases to make an early diagnosis and start the appropriate treatment.

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Polyarthritis and positive LE preparation in sickle hemoglobinopathies: A report of two cases

Cited by 20 publications

References 9 publications

Coexisting systemic lupus erythematosus and sickle cell disease: Case report and literature review

Coexisting systemic lupus erythematosus and sickle cell disease: Case report and literature review

Coexistência de lúpus eritematoso sistêmico e doença falciforme: relato de caso e revisão da literatura

Clinical and laboratory characteristics of patients with sickle-cell and autoimmune/connective tissue diseases

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