Polyaspartamide based hydrogel with cell recruitment properties for the local administration of hydrophobic anticancer drugs

Synthesis, Complex Formation and Corneal Permeation of Cyclodextrin-Modified, Thiolated Poly(Aspartic Acid) as Self-Gelling Formulation of Dexamethasone

“…The solubility isotherms are linear (A L -type), indicating a favourable interaction between the host and the guest and the complete solubility of the complex within the CD concentration range investigated, while the slope values below one suggest the formation of 1:1 complexes. The immobilization of CD on a polymer chain might affect the binding stability between the CD cavity and the hydrophobic drug, as observed by Fiorica et al [40] who obtained a significantly reduced complexation ability of immobilized CD with tamoxifen due to some steric hindrance. In contrast, Jalalvandi et al [43] observed an increased stability constant for PEGylated PASP derivatives which was explained by a possible synergistic effect between PEG chains and CD complexes.…”

“…The synthesis procedure of CD-functionalized PASP derivatives is largely determined by the chemical reactivity of the polymer and the CD used. Free radical polymerization was used to immobilize vinyl-modified CDs onto glycidyl methacrylated PASP derivatives [39], whereas vinyl sulfone functionalized CD was reacted with amine pendants of PASP derivatives to prepare hydrogel precursors [40]. Ring-opening polymerization of β-benzyl-L-aspartate in the presence of active CD was also used to prepare PASP-based formulations for plasmid DNA encapsulation [41].…”

Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles

“…Poly(α,β-(N-(3,4-dihydroxyphenethyl)-L-aspartamide-co-α,β-N-(2-hydroxyethyl)-Laspartamide) (PDAEA) was synthetized starting from polysuccinimide (PSI) [ 60 , 61 , 62 , 63 ], through successive PSI aminolysis reactions with dopamine and ethanolamine [ 64 ]. Initially 485 mg (5 mmol) of PSI were dispersed in 2 mL of DMSOa in a 25 mL flask, following argon bubbling for 15 min.…”

Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers

“…Cross-linking is a well-known strategy for preparing drug-loaded hydrogels or nanogels. The cross-linking reaction can occur between two polymers containing reactive functional groups [13,69,81], or between polymer and small molecule cross-linker [98][99][100][101]. Of course, enzymes can also be used as cross-linker to promote the cross-linking reaction of PASPAm derivatives for the preparation of nanogels [102].…”

“…For side chain-modified poly(aspartic acid)based polymers, they can generally be prepared by the aminolysis reaction of PSI. For example, a side chain-modified poly(aspartamide) (PASPAm) derivative, α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA), can be obtained by the aminolysis reaction between ethanolamine and PSI, and has been further modified and intensively studied as scaffolds [9], siRNA delivery systems [10,11] and drug carriers (e.g., hydrogel, nanoparticles) [12][13][14][15][16]. For the block copolymers containing poly(aspartic acid)-based segment, they usually can be synthesized by ROP of BLA-NCA.…”