Polycaprolactone based electrospun matrices loaded with Ag/hydroxyapatite as wound dressings: Morphology, cell adhesion, and antibacterial activity

Hassan, Abeer A.; Radwan, Hyam A.; Abdelaal, Said A.; Al‐Radadi, Najlaa S.; Ahmed, M. K.; Shoueir, Kamel R.; Hady, Mayssa Abdel

doi:10.1016/j.ijpharm.2020.120143

Cited by 56 publications

(25 citation statements)

References 59 publications

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“…The porosities of the 5% and 10% membranes were 83.0% and 72.5%, respectively. The data reported here are consistent with the common porosities of PCL membranes in literature which were in a range from 60% to 90% [ 32 , 33 , 34 ]. This difference in porosity indicates a greater void space in the 5% membrane compared to that in the 10% membrane.…”

Section: Resultssupporting

confidence: 91%

Electrospun Membranes as a Porous Barrier for Molecular Transport: Membrane Characterization and Release Assessment

et al. 2021

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Electrospun nanofibers have been extensively studied for encapsulated drugs releasing from the inside of the fiber matrix, but have been barely looked at for their potential to control release as a semi-permeable membrane. This study investigated molecular transport behaviors across nanofiber membranes with different micro-structure sizes and compositions. Four types of membranes were made by 5% and 10% poly (ε-caprolactone) (PCL) solutions electro-spun with or without 50 nm calcium carbonate (CaCO3) nanoparticles. The membranes were tested for thickness, fiber diameter, pore size, porosity, tensile strength and elongation, contact angle of water and their impacts on molecular transport behaviors. The presence of the CaCO3 nanoparticles made the 5% membranes stronger and stiffer but the 10% membranes weaker and less stiff due to the different (covering or embedded) locations of the nanoparticles with the corresponding fibers. Solute transport studies using caffeine as the model drug found the 5% membranes further retarded release from the 10% membranes, regardless of only half the amount of material being used for synthesis. The addition of CaCO3 nanoparticles aided the water permeation process and accelerated initial transports. The difference in release profiles between 5% and 10% membranes suggests different release mechanisms, with membrane-permeability dominated release for 5% PCL membranes and solute-concentration-gradient dominated release for 10% PCL membranes.

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Section: Resultssupporting

confidence: 91%

Electrospun Membranes as a Porous Barrier for Molecular Transport: Membrane Characterization and Release Assessment

et al. 2021

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“…Especially polymers, of both synthetic and natural origin, garner great attention in the field; among the naturally occurring polymers employed in dressing production, chitosan [107], hyaluronic acid [108], keratin [109], gelatin, starch [110], silk fibroin [111], heparin [112,113], collagen [114], sericin [115], sodium alginate [116,117], zein [118], and konjac glucomannan [119][120][121] can be enumerated [122,123]. On the other hand, polyvinyl alcohol (PVA) [110], polylactic acid (PLA) [124], polyacrylic acid (PAA) [110], polyethylene glycol (PEG) [125], polycaprolactone (PCL) [126], and polyvinylpyrrolidone (PVP) [127] are examples of synthetic polymers applied for that purpose [128].…”

Section: Modern Wound Dressing Materials and Nanomaterialsmentioning

confidence: 99%

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

et al. 2022

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Wound management is the burning problem of modern medicine, significantly burdening developed countries’ healthcare systems. In recent years, it has become clear that the achievements of nanotechnology have introduced a new quality in wound healing. The application of nanomaterials in wound dressing significantly improves their properties and promotes the healing of injuries. Therefore, this review paper presents the subjectively selected nanomaterials used in wound dressings, including the metallic nanoparticles (NPs), and refers to the aspects of their application as antimicrobial factors. The literature review was supplemented with the results of our team’s research on the elements of multifunctional new-generation dressings containing nanoparticles. The wound healing multiple molecular pathways, mediating cell types, and affecting agents are discussed herein. Moreover, the categorization of wound dressings is presented. Additionally, some materials and membrane constructs applied in wound dressings are described. Finally, bacterial participation in wound healing and the mechanism of the antibacterial function of nanoparticles are considered. Membranes involving NPs as the bacteriostatic factors for improving wound healing of skin and bones, including our experimental findings, are discussed in the paper. In addition, some studies of our team concerning the selected bacterial strains’ interaction with material involving different metallic NPs, such as AuNPs, AgNPs, Fe3O4NPs, and CuNPs, are presented. Furthermore, nanoparticles’ influence on selected eukaryotic cells is mentioned. The ideal, universal wound dressing still has not been obtained; thus, a new generation of products have been developed, represented by the nanocomposite materials with antibacterial, anti-inflammatory properties that can influence the wound-healing process.

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“…Natural products may offer an effective way to impair the viral infection cycle and treatment of this pandemic. In the light of use nanotechnology in the synthesis of nanoparticles that have anti-bacterial properties [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , and based on previous studies on antibacterial nanoparticles, nanotechnology can be used in the diagnosis or treatment of COVID-19. Recently, nanotechnology tools can play a pivotal role in advancing COVID-19 treatment and vaccine development.…”

Section: Conclusion and Future Prospectivementioning

confidence: 99%

Immunology and controlling of coronaviruses; the current enemy for humanity: A review

Othman

Nayel

Alwaele

et al. 2021

International Journal of Biological Macromolecules

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Polycaprolactone based electrospun matrices loaded with Ag/hydroxyapatite as wound dressings: Morphology, cell adhesion, and antibacterial activity

Cited by 56 publications

References 59 publications

Electrospun Membranes as a Porous Barrier for Molecular Transport: Membrane Characterization and Release Assessment

Electrospun Membranes as a Porous Barrier for Molecular Transport: Membrane Characterization and Release Assessment

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

Immunology and controlling of coronaviruses; the current enemy for humanity: A review

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