Polycaprolactone/oligomer compound scaffolds for cardiac tissue engineering

Reddy, Chaganti Srinivasa; Venugopal, Jayarama Reddy; Ramakrishna, Seeram; Zussman, Eyal

doi:10.1002/jbm.a.35045

Cited by 32 publications

(9 citation statements)

References 41 publications

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Section: Discussioncontrasting

confidence: 61%

“…According to the mechanical properties measured for these systems, Young's moduli obtained are slightly lower than the values obtained by Reddy et al (2014) for their PCL‐based structures for cardiac tissue engineering, but with similar maximum stress value (around 1.5–2.5 MPa). 46 In fact, analyzing the evolution of the parameters after the cyclic loading, a general decrease of the properties was observed, especially for Young's modulus and strain at break. The differences found in the stress–strain curves for the random and semi‐aligned systems (Figure 4 ) may be produced by a combination of two effects: The hydrophilic character of gelatin and the reorganization of the nanofibers.…”

Section: Discussionmentioning

confidence: 99%

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Fabrication of hybrid scaffolds obtained from combinations of PCL with gelatin or collagen via electrospinning for skeletal muscle tissue engineering

Perez‐Puyana

Wieringa

Yuste

et al. 2021

J Biomedical Materials Res

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The creation of skeletal muscle tissue in vitro is a major topic of interest today in the field of biomedical research, due to the lack of treatments for muscle loss due to traumatic accidents or disease. For this reason, the intrinsic properties of nanofibrillar structures to promote cell adhesion, proliferation, and cell alignment presents an attractive tool for regenerative medicine to recreate organized tissues such as muscle. Electrospinning is one of the processing techniques often used for the fabrication of these nanofibrous structures and the combination of synthetic and natural polymers is often required to achieve optimal mechanical and physiochemical properties. Here, polycaprolactone (PCL) is selected as a synthetic polymer used for the fabrication of scaffolds, and the effect of protein addition on the final scaffolds' properties is studied. Collagen and gelatin were the proteins selected and two different concentrations were analyzed (2 and 4 wt/vol%). Different PCL/protein systems were prepared, and a structural, mechanical and functional characterization was performed. The influence of fiber alignment on the properties of the final scaffolds was assessed through morphological, mechanical and biological evaluations. A bioreactor was used to promote cell proliferation and differentiation within the scaffolds. The results revealed that protein addition produced a decrease in the fiber size of the membranes, an increase in their hydrophilicity, and a softening of their mechanical properties. The biological study showed the ability of the selected systems to harbor cells, allow their growth and, potentially, develop musculoskeletal tissues.

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Section: Discussioncontrasting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Fabrication of hybrid scaffolds obtained from combinations of PCL with gelatin or collagen via electrospinning for skeletal muscle tissue engineering

Perez‐Puyana

Wieringa

Yuste

et al. 2021

J Biomedical Materials Res

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“…It is consequently an excellent choice of use as a supporting device, especially for hard tissues. There are several reports of its use in cardiac, bone, and cartilage engineering [106][107][108][109][110][111][112][113].…”

Section: Printable Hydrogelsmentioning

confidence: 99%

Bioresorbable Polymers: Advanced Materials and 4D Printing for Tissue Engineering

Saska¹,

Pilatti²,

Blay³

et al. 2021

Polymers

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Three-dimensional (3D) printing is a valuable tool in the production of complexes structures with specific shapes for tissue engineering. Differently from native tissues, the printed structures are static and do not transform their shape in response to different environment changes. Stimuli-responsive biocompatible materials have emerged in the biomedical field due to the ability of responding to other stimuli (physical, chemical, and/or biological), resulting in microstructures modifications. Four-dimensional (4D) printing arises as a new technology that implements dynamic improvements in printed structures using smart materials (stimuli-responsive materials) and/or cells. These dynamic scaffolds enable engineered tissues to undergo morphological changes in a pre-planned way. Stimuli-responsive polymeric hydrogels are the most promising material for 4D bio-fabrication because they produce a biocompatible and bioresorbable 3D shape environment similar to the extracellular matrix and allow deposition of cells on the scaffold surface as well as in the inside. Subsequently, this review presents different bioresorbable advanced polymers and discusses its use in 4D printing for tissue engineering applications.

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“…Reddy et al proposed a compound of PCL and an oligomer hydrogel [Bisphenol A ethoxylated dimethacrylate (BPAEDMA)] for the fabrication of electrospun scaffolds [81]. The elastic modulus of PCL/BPAEDMA nanofibrous scaffolds was found to be decreased with the increase of the BPAEDMA weight fraction.…”

Section: Poly(ε-caprolactone)-based Scaffoldsmentioning

confidence: 99%

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

et al. 2017

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Please cite this article as: Kitsara, M., Agbulut, O., Kontziampasis, D., Chen, Y., Menasché, P., Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering, Acta Biomaterialia (2016), doi: http://dx.doi.org/ 10. 1016/j.actbio.2016.11.014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractCardiac cell therapy holds a real promise for improving heart function and especially of the chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better preserve cell survival and enhance cell engraftment after transplantation, consequently improving cardiac cell therapy compared with direct intramyocardial injection of isolated cells.The primary objective of a scaffold used in tissue engineering is the recreation of the natural 3D environment most suitable for an adequate tissue growth. An important aspect of this commitment is to mimic the fibrillar structure of the extracellular matrix, which provides essential guidance for cell organization, survival, and function. Recent advances in nanotechnology have significantly improved our capacities to mimic the extracellular matrix. Among them, electrospinning is well known for being easy to process and cost effective. Consequently, it is becoming increasingly popular for biomedical applications and it is most definitely the cutting edge technique to make scaffolds that mimic the extracellular matrix for industrial applications.Here, the desirable physico-chemical properties of the electrospun scaffolds for cardiac therapy are described, and polymers are categorized to natural and synthetic. Moreover, the methods used for improving functionalities by providing cells with the necessary chemical cues and a more in vivo-like environment are reported.

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Polycaprolactone/oligomer compound scaffolds for cardiac tissue engineering

Cited by 32 publications

References 41 publications

Fabrication of hybrid scaffolds obtained from combinations of PCL with gelatin or collagen via electrospinning for skeletal muscle tissue engineering

Fabrication of hybrid scaffolds obtained from combinations of PCL with gelatin or collagen via electrospinning for skeletal muscle tissue engineering

Bioresorbable Polymers: Advanced Materials and 4D Printing for Tissue Engineering

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

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