Polycaprolactone/polyvinyl alcohol core-shell nanofibers as a pH-responsive drug carrier for the potential application in chemotherapy against colon cancer

Yan, Eryun; Jiang, Jinyu; Ren, Xihua; Gao, Junkai; Zhang, Xunhai; Li, Shuhua; Chen, Shengnan; Li, Yuxin

doi:10.1016/j.matlet.2021.129516

Cited by 16 publications

(7 citation statements)

References 7 publications

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“…In the 1 H-NMR spectrum of CsA, it can be observed that after the functionalization reaction, the doublet of the doublets peak was shifted towards lower values (2.69-2.83 ppm), indicating the successful covalent attachment of CA on the CS polymer chains [33]. Additionally, in the 13 C-NMR spectrum of CsA (Figure 2b), it can be observed that besides the four carbon atoms characteristic for CA (C1 -44.37 ppm, C2 -74.29 ppm, C3 -176.11 ppm, C4 -179.59 ppm), the carbon atoms coming from the molecular structure of CS are also shown (C1*, C2*, C3*, C4*, C5*, C6*, C7*) [34].…”

Section: Structural Characterization Of Functionalized Raw Materials ...mentioning

confidence: 96%

“…In the 1 H-NMR spectrum of CsA, it can be observed that after the functionalization reaction, the doublet of the doublets peak was shifted towards lower values (2.69-2.83 ppm), indicating the successful covalent attachment of CA on the CS polymer chains [33]. Additionally, in the 13 C-NMR spectrum of CsA (Figure 2b), it can be observed that besides Then, ATR-FTIR spectrometry, as a complementary technique for 1 H-NMR spectroscopy, was used to confirm the covalent functionalization of CS with CA (the synthesis of CsA), and the recorded FTIR spectra of CS, CA, and CsA are shown in Figure 2c.…”

Section: Structural Characterization Of Functionalized Raw Materials ...mentioning

confidence: 96%

“…1 H-NMR and 13 C-NMR spectra were recorded on a Bruker Avance III HD 600 NMR spectrometer (Bruker Biospin, Rheinstetten, Germany) at a resonance frequency of 600.12 and 150.90 MHz, respectively. Before analysis, all the compounds were solubilized in D 2 O/HCl solution (pH = 3).…”

Section: Structural Characterizationmentioning

confidence: 99%

“…Electrospinning represents a modern and widely used technology to generate thin fibers with diameters in the nanometer range with controlled architecture and different configurations by varying certain solution or process parameters and the electrospinning system/mode [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Electrospun Nanofibrous Membranes Based on Citric Acid-Functionalized Chitosan Containing rGO-TEPA with Potential Application in Wound Dressings

et al. 2022

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The present research work is focused on the design and investigation of electrospun composite membranes based on citric acid-functionalized chitosan (CsA) containing reduced graphene oxide-tetraethylene pentamine (CsA/rGO-TEPA) as materials with opportune bio-properties for applications in wound dressings. The covalent functionalization of chitosan (CS) with citric acid (CA) was achieved through the EDC/NHS coupling system and was checked by 1H-NMR spectroscopy and FTIR spectrometry. The mixtures to be electrospun were formulated by adding three concentrations of rGO-TEPA into the 1/1 (w/w) CsA/poly (ethylene oxide) (PEO) solution. The effect of rGO-TEPA concentration on the morphology, wettability, thermal stability, cytocompatibility, cytotoxicity, and anti-biofilm activity of the nanofibrous membranes was extensively investigated. FTIR and Raman results confirmed the covalent and non-covalent interactions that appeared between the system’s compounds, and the exfoliation of rGO-TEPA sheets within the CsA in the presence of PEO (CsA/P) polymer matrix, respectively. SEM analysis emphasized the nanofibrous architecture of membranes and the presence of rGO-TEPA sheets entrapped into the CsA nanofiber structure. The MTT cellular viability assay showed a good cytocompatibility with the highest level of cell development and proliferation registered for the CsA/P composite nanofibrous membrane with 0.250 wt.% rGO-TEPA. The designed nanofibrous membranes could have potential applications in wound dressings, given that they showed a good anti-biofilm activity against Gram-negative Pseudomonas aeruginosa and Gram-positive Staphylococcus aureus bacterial strains.

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Section: Structural Characterization Of Functionalized Raw Materials ...mentioning

confidence: 96%

“…In the 1 H-NMR spectrum of CsA, it can be observed that after the functionalization reaction, the doublet of the doublets peak was shifted towards lower values (2.69-2.83 ppm), indicating the successful covalent attachment of CA on the CS polymer chains [33]. Additionally, in the 13 C-NMR spectrum of CsA (Figure 2b), it can be observed that besides Then, ATR-FTIR spectrometry, as a complementary technique for 1 H-NMR spectroscopy, was used to confirm the covalent functionalization of CS with CA (the synthesis of CsA), and the recorded FTIR spectra of CS, CA, and CsA are shown in Figure 2c.…”

Section: Structural Characterization Of Functionalized Raw Materials ...mentioning

confidence: 96%

Section: Structural Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrospun Nanofibrous Membranes Based on Citric Acid-Functionalized Chitosan Containing rGO-TEPA with Potential Application in Wound Dressings

et al. 2022

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“…The majority of the research is designed either with a hydrophilic or hydrophobic shell but with a hydrophobic core, mainly due to the difficulty in fabricating a hydrophilic core with a hydrophobic shell 16,17,26,33 . The fabrication of core–shell nanofibres with a hydrophilic core requires precise control of the electrospinning parameters.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional core–shell electrospun nanofibrous fabrics of poly(vinyl alcohol)/silk sericin (core) and poly(lactide‐co‐glycolide) (shell)

Tuancharoensri

Ross

Punyodom

et al. 2021

Polymer International

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Core–shell fibres (CSFs) offer a simple route to multifunctional hybrid materials for a wide range of applications. Herein, we report the design of a core–shell electrospun nanofibrous fabric containing a hydrophilic core and hydrophobic shell. CSFs were fabricated for the first time from poly(vinyl alcohol)/silk sericin (from silk cocoons) as the core and poly(lactide‐co‐glycolide) as the shell. The core serves as a potential carrier for water‐soluble bioactive agents, and the shell works as a barrier to prevent premature release of water‐soluble agents from the core. The effect of the molecular weight of poly(lactide‐co‐glycolide) and the loading of silk sericin on the morphology of fibres was studied. The parameters that significantly influence the core–shell electrospinning process were studied to elucidate the most effective conditions to create our multifunctional nanofibrous fabrics with smooth fibre morphology (diameters in the range 800–1300 nm) and low bead formation. Our CSFs were shown to degrade in saline buffer solution (pH 7.4) and were readily rendered with anti‐bacterial properties against Staphylococcus aureus and Escherichia coli by the post‐spinning deposition of silver nanoparticles (AgNPs, 40 nm diameter) or cinnamon essential oil (CEO). The fibres were non‐toxic to normal human dermal fibroblast cell lines, as the cells were shown to attach and proliferate on CSFs, CSF/AgNPs and CSF/CEO with good cell tolerance for 72 h of incubation. These smart multifunctional CSFs show great potential towards smart delivery fabrics/dressings capable of carrying water‐soluble bioactive agents surrounded by a protective, but degradable, antibacterial shell to guard the cargo for more effective controlled release. © 2021 Society of Industrial Chemistry.

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Potential of uniaxial electrospun composite nanofibers based on polycaprolactone and polyvinyl alcohol in guided bone regeneration

Jiang

Liu

Cheng

et al. 2023

J of Applied Polymer Sci

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Polycaprolactone and polyvinyl alcohol are commonly used polymers with biocompatibility and biodegradability. However, the poor mechanical properties of polycaprolactone and the high swelling properties of polyvinyl alcohol hinder their application in guided tissue/bone regeneration. In this study, a new strategy for preparing absorbable guided bone regeneration (GBR) membrane was innovatively put forward, which was to simply blend them in formic acid in different proportions (0%/100%, 25%/75%, 50%/50%, 75%/25%, and 100%/0% wt/wt) and obtain nanofiber membrane by uniaxial electrospinning. The nano‐structure was confirmed by scanning electron microscope, and the change of chemical functional groups was confirmed by Fourier transform infrared spectroscopy. In addition, the proper polymer proportion (75%/25%) was selected through some tests. The results show that the nanofiber membrane has suitable wettability (104.083 ± 2.512°), sufficient Young's modulus (90.895 ± 7.431 MPa), the lowest swelling rate (33.705 ± 1.806%) and shrinkage rate (1.878 ± 3.252%), and no cytotoxicity. Its biodegradability and osteogenic effects in vitro were also investigated to show the potential applied in GBR.

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Polycaprolactone/polyvinyl alcohol core-shell nanofibers as a pH-responsive drug carrier for the potential application in chemotherapy against colon cancer

Cited by 16 publications

References 7 publications

Electrospun Nanofibrous Membranes Based on Citric Acid-Functionalized Chitosan Containing rGO-TEPA with Potential Application in Wound Dressings

Electrospun Nanofibrous Membranes Based on Citric Acid-Functionalized Chitosan Containing rGO-TEPA with Potential Application in Wound Dressings

Multifunctional core–shell electrospun nanofibrous fabrics of poly(vinyl alcohol)/silk sericin (core) and poly(lactide‐co‐glycolide) (shell)

Potential of uniaxial electrospun composite nanofibers based on polycaprolactone and polyvinyl alcohol in guided bone regeneration

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