Polycarbonate Micelles for Cancer Therapy

Danquah, Michael

doi:10.4172/1948-5956.1000286

Cited by 2 publications

(2 citation statements)

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“…[21][22][23][24][25] In this case, the APCs can play the role of hydrophobic (HPO) core-forming blocks for drug delivery of micellar nanocarriers. [26][27][28][29][30] In drug delivery systems, in order to control the in vivo drug release rate with a prolonged…”

Section: Doi: 101002/mame201700042mentioning

confidence: 99%

“…APCs can also be used for the preparation of modern nanostructures like polymeric micelles that carry drugs through the bloodstream and deliver them to the desired locations in order to act within tumors . In this case, the APCs can play the role of hydrophobic (HPO) core‐forming blocks for drug delivery of micellar nanocarriers . In drug delivery systems, in order to control the in vivo drug release rate with a prolonged circulation time, scientists have suggested polymeric micelle based APC block copolymers (BCPs) .…”

Section: Introductionmentioning

confidence: 99%

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Nanocomposites of Polymeric Biomaterials Containing Carbonate Groups: An Overview

Taraghi

Paszkiewicz

Grȩbowicz

et al. 2017

Macro Materials & Eng

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The modification of biomaterials using nanoadditives can lead to the development of novel materials for a wide variety of biomedical applications such as drug administration systems, tissue engineering, bioresistance coatings, and biomedical instruments. Moreover, a further improvement of mechanical and thermal properties of aforementioned biomaterials while maintaining their dimensional stability is a goal of major scientific researches. Aliphatic polycarbonates (APCs) containing carbonate groups such as poly(trimethylene carbonate), poly(propylene carbonate), poly(ethylene carbonate), poly(dimethyl trimethylene carbonate), etc., have become much more interesting compared to other biodegradable materials due to their unique physical and chemical properties. This review presents the effect of applying different kinds of nanoparticles (NPs) on the mechanical, thermal, and viscoelastic properties as well as dimensional stability and biocompatibility of APCs. The dispersion process of nanofillers within polymer matrices has been divided into two groups, solution and melt mixing techniques. Moreover, synthesis procedures of APC loaded NPs for drug delivery systems and electrospinning of nanofiber mats have also been reviewed. In order to clarify the effect of NPs on the overall characteristics of the APC biomaterials, the detailed mechanism of improving process have been extensively discussed.

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