Polychlorinated biphenyls as initiators in liver carcinogenesis: resistant hepatocyte model

Espandiari, Parvaneh; Glauert, Howard P.; Lehmler, Hans‐Joachim; Lee, Eun Young; Srinivasan, Cidambi; Robertson, Larry W.

doi:10.1016/s0041-008x(02)00018-2

Cited by 79 publications

(78 citation statements)

References 45 publications

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“…ROS are also able to reduce telomerase activity which can determine telomere shortening. The contribution of all or part of these alterations may facilitate the onset of tumors and more specifically HCC [200][201][202][203][204][205] . At present we have no conclusive data on the relationship between PCBs and HCC and further studies will be needed to establish the causal link.…”

Section: Polychlorinated Biphenylsmentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson's disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. Core tip: Hepatocellular carcinoma (HCC) is the fifth most common human cancer. This review summarizes current knowledge regarding the occupational risk factors of HCC. In particular, we underline not only the infective but also non-infective occupational risk exposure, including chemical agents and toxic metabolites which are a major cause of liver damage.

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Section: Polychlorinated Biphenylsmentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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“…This class of chemicals has been linked to toxic effects observed for a number of organ systems including hepatic, endocrine, cardiac, immune, nervous, dermatologic, reproductive, gastrointestinal, and respiratory systems. Moreover, PCB exposure has also been shown in mammalian studies to have mutagenic and carcinogenic effects (Hayes, 1987;Parkinson and Safe, 1987;Espandiari et al, 2003), and specifically may play a role in tumor promotion (Tharappel et al, 2002). Considering the environmental persistence in combination with the toxic potential for exposed populations (animal and human), PCBs continue to be of great concern from an environmental and public health perspective.…”

Section: Introductionmentioning

confidence: 99%

Non-coplanar polychlorinated biphenyl (PCB)-induced immunotoxicity is coincident with alterations in the serotonergic system

Duffy-Whritenour

Kurtzman

Kennedy

et al. 2010

Journal of Immunotoxicology

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“…Several low chlorinated biphenyl congeners, including PCB3, were positive in the modified Solt-Farber protocol (Espandiari et al, 2003). A follow up study revealed that in addition to PCB3, its 4-OH and the 3,4-quinone metabolites were positive in this assay (Espandiari et al, 2004).…”

Section: Discussionmentioning

confidence: 87%

“…PCB3 and the hydroxylated metabolite, 4-OH-PCB3 were synthesized, purified, and characterized as described (Espandiari et al, 2003). Agar and 3-MC were purchased from Sigma (St. Louis MO).…”

Section: Chemical Substancesmentioning

confidence: 99%

“…On postnatal day 37 animals were weighed, distribution into four exposure groups with four animals each, and received the first of 4 weekly intraperitoneal injections of either corn oil (5 ml/kg body weight (bw)), 3-MC (80 mg/kg bw), PCB3 (113 mg/kg bw) or 4-OH-PCB3 (82 mg/kg bw). The doses of PCB3 and 4-HO-PCB3 were based on previous studies (Espandiari, et al 2003;Espandiari et al 2004). During the entire exposure period, animals were monitored daily to assess well-being and weighed twice a week.…”

Section: Exposure Protocolmentioning

confidence: 99%

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Mutagenicity of 3-methylcholanthrene, PCB3, and 4-OH-PCB3 in the lung of transgenic BigBlue® rats

Maddox

Wang

Kirby

et al. 2008

Environmental Toxicology and Pharmacology

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Recent findings of high levels of predominantly lower chlorinated biphenyls in indoor and outdoor air open the question of possible health consequences. Lower chlorinated biphenyls are more readily metabolized to reactive and potentially harmful intermediates, acting as mutagens and cancer initiators. The goal of this study was to assess the mutagenicity of PCB3 in the lungs of rats. Male BigBlue® 334 Fisher transgenic rats, which carry the bacterial lacI gene as a target of mutagenicity, were given intraperitoneal injections of corn oil, 3-methylcholanthrene (3-MC, positive control), 4-monochlorobiphenyl (PCB3) or its metabolite 4-hydroxy-PCB3 (4-OH-PCB3) weekly for 4 weeks. Lungs tissue was harvested to determine mutant frequencies, mutation spectra, and pathological changes. 3-MC caused a 15-fold increase in mutant frequency and an increase in transversion type mutations; a very early occurrence of this type of mutation in lung tissue was previously identified in Ki-ras oncogenes of lung tumors from 3-MC exposed mice. The 2-fold increase in the mutant frequency after treatment with PCB3 and 4-OH-PCB3 was not statistically significant, but a shift in the mutation spectra, especially with PCB3, and an increase in mutations outside of the hotspot region for spontaneous mutations (bp 1-400), suggest that PCB3 and possibly 4-OH-PCB3 are mutagenic in the rat lung.

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Polychlorinated biphenyls as initiators in liver carcinogenesis: resistant hepatocyte model

Cited by 79 publications

References 45 publications

Hepatocellular carcinoma and the risk of occupational exposure

Hepatocellular carcinoma and the risk of occupational exposure

Non-coplanar polychlorinated biphenyl (PCB)-induced immunotoxicity is coincident with alterations in the serotonergic system

Mutagenicity of 3-methylcholanthrene, PCB3, and 4-OH-PCB3 in the lung of transgenic BigBlue® rats

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