Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls, naphthalenes and polybrominated diphenyl ethers in the edible fish caught from the Baltic Sea and lakes in Finland

Isosaari, Pirjo; Hallikainen, Anja; Kiviranta, Hannu; Vuorinen, Pekka J.; Parmanne, Raimo; Koistinen, Jaana; Vartiainen, Terttu

doi:10.1016/j.envpol.2005.08.055

Cited by 125 publications

(56 citation statements)

References 35 publications

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“…PBDEs levels in biotic tissues from polluted regions are obviously higher than those from the general environment, and consequently we summarized the data from these environments separately. The percentile method is a useful method for estimating background concentrations of chemical pollutants in biotic and environmental samples (Chen et al, 2010;Isosaari et al, 2006). The 90th percentile level as well as the 95th percentile level is used to estimate the upper extremes of pollutant concentrations.…”

Section: Literature Data On Environmental Exposure Levels Of Biotic Tmentioning

confidence: 99%

Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies

Wei

Zhao

Liu

et al. 2010

Toxicology in Vitro

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a b s t r a c tToxicological studies at environmentally relevant concentrations are essential for understanding ecotoxic and health risks of pollutants such as polybrominated diphenyl ethers (PBDEs). However, no information is available on what exposure levels of PBDEs in vitro studies are environmentally relevant. We exposed MCF-7, HepG2, H295R and PC12 cells to BDE-47, and measured BDE-47 concentrations in the cells after exposure. We also used the percentile method to summarize literature data on environmental exposure levels of biotic tissues to PBDEs. The exposure concentration that resulted in a BDE-47 burden in cells close to the 90th percentile of PBDEs levels in tissues was assigned as the upper limit for the environmentally relevant concentration. Exposure to 1 nM BDE-47 resulted in PBDEs burdens in MCF-7, HepG2 and H295R cells close to the 90th percentile but PBDEs burdens in PC12 cells were higher than the 90th percentile. In consideration of the high exposure levels in PBDE-polluted areas, we concluded that the highest environmentally relevant exposure concentration of PBDEs in culture media should be approximately 10 nM for MCF-7, HepG2 and H295R cells, and <10 nM for PC12 cells. These results provide an approximate reference for setting environmentally relevant exposure concentrations of PBDEs for studies in vitro.

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Section: Literature Data On Environmental Exposure Levels Of Biotic Tmentioning

confidence: 99%

Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies

Wei

Zhao

Liu

et al. 2010

Toxicology in Vitro

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“…Many of these chemicals occur at elevated levels in farmed and wild salmon (Isosaari et al 2006;Jacobs et al 2002;Shaw et al 2006). Studies on various salmonid species have identified several tissues as primary targets for TCDD-induced pathologic lesions (e.g.…”

Section: Introductionmentioning

confidence: 99%

Functional properties of the four Atlantic salmon (Salmo salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms

Hansson

Hahn

2008

Aquatic Toxicology

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The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor through which organochlorine contaminants including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons induce toxicity and altered gene expression. Atlantic salmon has multiple AHR genes, of which two belong to the AHR1 clade and four belong to the AHR2 clade. The four AHR2 forms (α, β, γ, δ) are more highly expressed than the AHR1 (α, β,) forms and all six AHRs are highly similar in pairs, likely originating from a whole-genome duplication in the salmonid ancestor. It has been speculated that having multiple AHRs contributes to the very high sensitivity of salmonid species to TCDD and related chemicals. To test the hypothesis that all four salmon AHR2 proteins are expressed and functional, we measured mRNA transcription for each AHR2 inside several tissues, cloned the cDNAs and evaluated the functional properties of the expressed proteins. Analysis by real-time PCR revealed that the receptors showed differences in transcript levels among salmon tissues and that in general AHR2α was transcribed at higher levels than the other three AHR2s. Velocity sedimentation analysis showed that all four in vitro-expressed AHR2 proteins exhibit specific, high-affinity binding of [ 3 H]TCDD. When expressed in COS-7 cells, all four AHR2 proteins were able to drive the expression of a reporter gene under control of murine CYP1A1 enhancer elements. From EC 50 values determined in TCDD concentration-response experiments, all four salmon AHR2s show similar sensitivity to TCDD. In summary, all four Atlantic salmon AHR2 appear to function in AHR-mediated signaling, suggesting that all four proteins are involved in TCDD-mediated toxicity.

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“…Most organohalogen contaminants released over the years are still present in the aqueous environment and thus are accessible to marine organisms. Elevated concentrations of PCDDs, PCDFs, and dl-PCBs in some Baltic fish species (salmon, herring, and sprat) have been shown in several surveys in European member states (18,25,30). Recently the contamination profiles of PBDDs and PBDFs were described in the tissue of Baltic wild salmon and compared with chlorinated dioxins, dibenzofurans, and PCBs.…”

Section: Fig 2 Electronic Wastementioning

confidence: 99%

“…Due to the prevalence of 2,3,7,8-substituted PBDDs and PBDFs, particularly in the aquatic environment, it is not surprising that these compounds have been detected in seafood for human consumption (1,5,10,18). Fish and seafood are generally recommended by nutritionists as healthy foods that provide a good source of protein.…”

Section: Fig 2 Electronic Wastementioning

confidence: 99%

Brominated Dioxins: Little-Known New Health Hazards - A Review

Piskorska-Pliszczyńska

Maszewski

2014

Bulletin of the Veterinary Institute in Pulawy

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This article reviews the present state of the science concerning the polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). Everywhere in the world people are exposed to anthropogenic origin chemicals. Some of them are longlived organic compounds, which persist over the years in the environment. Persistent organic pollutants, such as organohalogen compounds, accumulate in environmental and biological compartments and have adverse effects on the health of humans and animals. Little is known about the brominated and mixed chloro/bromo dioxin and furans. Existing literature suggests that brominated dioxins and furans have similar toxicity profiles to their chlorinated analogues. The exposure data are extremely limited, showing a major data gap in estimating the potential environmental and health risk of these chemicals. The rapid increase in the use of brominated flame retardants (the main source of these pollutants) has raised the level of concern over environmental and health damage from brominated dioxins and furans. It is likely that human as well as wildlife exposure to these contaminants will increase with their greater use. The findings reported here present strong evidence of the PBDDs and PBDFs as an emerging new class of contaminants.

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Polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls, naphthalenes and polybrominated diphenyl ethers in the edible fish caught from the Baltic Sea and lakes in Finland

Cited by 125 publications

References 35 publications

Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies

Determination of environmentally relevant exposure concentrations of polybrominated diphenyl ethers for in vitro toxicological studies

Functional properties of the four Atlantic salmon (Salmo salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms

Brominated Dioxins: Little-Known New Health Hazards - A Review

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