Polycyclic Aromatic Hydrocarbons in Maternal and Cord Blood Plasma

Radmacher, Paula G.; Looney, Stephen W.; Myers, Steven R.

doi:10.1080/10406631003800639

Cited by 5 publications

(1 citation statement)

References 88 publications

(93 reference statements)

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“…The main exposure pathways of PAHs and their derivatives for the human body include inhalation, ingestion, and dermal contact [ 13 ]. The exogenous chemicals of pollutants are first absorbed by the blood and then distributed, metabolized, and excreted through the blood system, which can then be transported to a depot or target organ [ 14 , 15 ]. The effects of exposure to PAHs on human health have been demonstrated by many studies.…”

Section: Introductionmentioning

confidence: 99%

The Levels of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Plasma and Their Effect on Mitochondrial DNA Methylation in the Oilfield Workers

Jia

Liu³

et al. 2023

Toxics

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This study focuses on the components and levels of polycyclic aromatic hydrocarbons (PAHs) and their derivatives (MPAHs and OPAHs) in plasma samples from 19 oil workers, pre- and post-workshift, and their exposure–response relationship with mitochondrial DNA (mtDNA) methylation. PAH, MPAH, OPAH, and platelet mtDNA methylation levels were determined using a gas chromatograph mass spectrometer (GC-MS) and a pyrosequencing protocol, respectively. The total plasma concentrations of PAHs in mean value were, respectively, 31.4 ng/mL and 48.6 ng/mL in pre- and post-workshift, and Phe was the most abundant (13.3 ng/mL in pre-workshift and 22.1 ng/mL in post-workshift, mean value). The mean values of total concentrations of MPAHs and OPAHs in the pre-workshift were 2.7 ng/mL and 7.2 ng/mL, while in the post-workshift, they were 4.5 ng/mL and 8.7 ng/mL, respectively. The differences in the mean MT-COX1, MT-COX2, and MT-COX3 methylation levels between pre- and post-workshift were 2.36%, 5.34%, and 0.56%. Significant (p < 0.05) exposure–response relationships were found between PAHs and mtDNA methylation in the plasma of workers; exposure to Anthracene (Ant) could induce the up-regulation of the methylation of MT-COX1 (β = 0.831, SD = 0.105, p < 0.05), and exposure to Fluorene (Flo) and Phenanthrene (Phe) could induce the up-regulation of methylation of MT-COX3 (β = 0.115, SD = 0.042, p < 0.05 and β = 0.036, SD = 0.015, p < 0.05, respectively). The results indicated that exposure to PAHs was an independent factor influencing mtDNA methylation.

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Section: Introductionmentioning

confidence: 99%