Polycystic Ovarian Syndrome and Fertility

Lentscher, Jessica A.; Slocum, Breonna; Torrealday, Saioa

doi:10.1097/grf.0000000000000595

Cited by 21 publications

(14 citation statements)

References 50 publications

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“…In our research, the number of ovarian follicles was significantly increased (p<0.05) to 18.78+1.20 (Mean+SD) in the PCOS patients. Our findings were in close liaison with Lentscher et al [13]. The results of our study were also supported by a study in which ≥12 follicles on the ovaries were found [6].…”

Section: Discussionsupporting

confidence: 92%

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Clinical manifestations, hormonal profile and rationale of the polycystic ovary syndrome and infertility in Pakistani women

Monika¹,

Malik²,

Waqar³

et al. 2023

ijhs

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Introduction: Many women of reproductive age experience polycystic ovary syndrome (PCOS), characterized by growth of cysts on the ovaries that range in size from 2 to 10mm in antral measurement, oligomenorrhea, menorrhagia, acne and hyperandrogenism. Objective: The study aimed to correlate the rational of PCOS with infertility in women. Place and Duration: The study was conducted in different districts of Sindh in Pakistan during the period 2020-22. Methods: This cross-sectional study aimed to determine how common infertility was among women with PCOS who sought care at different gynecological clinics. Pathological investigation of the patient's hormonal profile, including serum insulin, serum prolactin, LH, FSH, and serum testosterone levels were also investigated. Results: 316 of infertile women (63.20%) were diagnosed with PCOS. Females had oligomenorrhea as the predominant (p<0.05) pattern of the PCOS-affected females. Acne, hirsutism, and hyperandrogenism were significantly (P<0.05) more common among these women. In women with PCOS, the level of testosterone was significantly elevated (132+2.39 ng/dl; P<0.05). Conclusion: PCOS is the leading cause of infertility owing to anovulation, as affected women displayed severe clinical manifestations of oligomenorrhea, hirsutism, acne, hyperandrogenism, and elevated testosterone levels and thus can easily be diagnosed and treated accordingly.

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Section: Discussionsupporting

confidence: 92%

“…The highest incidence was found by Zandi et al who found a 60.2% incidence of PCOS by NIH criteria [12]. Spontaneous abortions and miscarriages were also caused by PCOS [13]. A study in Nigeria reported a 55.2% incidence of PCOS in infertile women [14,15].…”

Section: Discussionmentioning

confidence: 99%

Clinical manifestations, hormonal profile and rationale of the polycystic ovary syndrome and infertility in Pakistani women

Monika¹,

Malik²,

Waqar³

et al. 2023

ijhs

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“…According to the American Society of Reproductive Medicine (ASRM), 70-80% of women with PCOS are infertile. In addition, the Centers for Disease Control and Prevention (CDC) state that PCOS is the most frequent cause of infertility [17]. Drugs like clomiphene citrate and letrozole are usually employed for the induction of ovulation in women with PCOS undergoing fertility treatment [18].…”

Section: Introductionmentioning

confidence: 99%

A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds (Nigella sativa) in the Management of Polycystic Ovarian Syndrome (PCOS)

Balasubramanian¹,

Maideen

Muthusamy³

et al. 2023

J Pharmacopuncture

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Objectives: Polycystic ovary syndrome (PCOS) is a condition that occurs frequently among women of reproductive age and is a polygenic, multifactorial, endocrine, and metabolic disorder. PCOS is becoming more common as a result of risk factors such as current lifestyle, overnutrition, and stress. The use of traditional herbal medicine is higher among the global population. Hence, this review article focuses on the potential of Nigella sativa to manage women with PCOS. Methods: A literature search was carried out using databases including Medline, Google Scholar, EBSCO, Embase, and Science Direct, as well as reference lists, to identify relevant publications that support the use of N. sativa in the management of women with PCOS. Results: Several clinical and preclinical studies have demonstrated that the major bioactive constituent of black seed (N. sativa), thymoquinone, has potential for managing women with PCOS. Moreover, N. sativa may help to manage oligomenorrhea and amenorrhea in women with PCOS through its anti-inflammatory and antioxidant properties. Conclusion: N. sativa has potential for use as a herbal medicine for managing women with PCOS as an integrative medicine along with traditional and modern medicine in conjunction with calorie restriction and regular exercise.

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“…Polycystic ovary syndrome (PCOS) is the most common diagnosed endocrine disorder in women [ 1 ] and a major cause of anovulatory infertility. The prevalence is thought to range from 4% to 26% depending on the population studied [ 2 , 3 , 4 ]. PCOS patients can present a wide range of signs and symptoms, making it difficult to agree on the precise definition of the condition.…”

Section: Introductionmentioning

confidence: 99%

Polycystic Ovarian Syndrome (PCOS): Does the Challenge End at Conception?

Mirza

Tahlak

Rjeili

et al. 2022

IJERPH

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Polycystic ovary syndrome (PCOS) is a prevalent condition that not only has the potential to impede conception but also represents the most common endocrine dysfunction in fertile women. It is considered a heterogeneous and multifaceted disorder, with multiple reproductive and metabolic phenotypes which differently affect the early- and long-term syndrome’s risks. Undoubtedly, the impact of PCOS on infertility has attracted most of the attention of healthcare providers and investigators. However, there is growing evidence that even after conception is achieved, PCOS predisposes the parturient to several adverse pregnancy outcomes including a high risk of pregnancy-induced hypertension, spontaneous abortion, gestational diabetes, preeclampsia, and preterm birth, which increase the risks of stillbirth and neonatal death. Fetal growth abnormalities may also be more common, but the relationship is less well defined. This narrative review aims to summarize current knowledge regarding these conditions as they interplay with PCOS and concludes that although there appears to be an increase in these complications during the pregnancy of women with PCOS, there is a need for further research to clarify the possible confounding impact of obesity. Implications for clinical practice and future research are outlined.

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Polycystic Ovarian Syndrome and Fertility

Cited by 21 publications

References 50 publications

Clinical manifestations, hormonal profile and rationale of the polycystic ovary syndrome and infertility in Pakistani women

Clinical manifestations, hormonal profile and rationale of the polycystic ovary syndrome and infertility in Pakistani women

A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds (Nigella sativa) in the Management of Polycystic Ovarian Syndrome (PCOS)

Polycystic Ovarian Syndrome (PCOS): Does the Challenge End at Conception?

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