Background: To determine the association of primary subfertility in Polycystic Ovaries with BMI and waist circumference. Methods: This cross-sectional study was performed from 01-08-2018 to 01-08-2019 at the Department of Obstetrics & Gynecology, Indus Medical College, Tando Muhammad Khan on (n=245) diagnosed with polycystic ovaries in the age group of 18 to 49 years. The study population, having diabetes mellitus, increased prolactin levels, disturbed thyroid function, congenital adrenal hyperplasia, and the couples with contraceptive measures were not included. Mean ± SD was computed for numerical data, frequencies and percentages were computed for qualitative data. Chi-square was used as a test of significance with a P-value <0.05 as significant. Results: The mean ± SD age of these women was 33.46±6.71 years with a range from 18 to 45 years. The proportion of subfertility in PCOS was 40.41%. The frequency of subfertility in PCO increases from normal weight to obesity significantly. (P-value <0.01) Additionally; women presenting with PCOS and increased waist circumference had a higher frequency of subfertility. (P-value <0.01). Conclusion: A much higher proportion of women with PCOS who present with obesity, overweight, and higher waist circumference were subfertile. With early screening and treatment for PCOS, weight control also is necessary to prevent the big issue of subfertility. Keywords: Obesity, Polycystic Ovarian Syndrome. Subfertility.