Polycythaemia, Leuco-erythroblastosis, and Myelosclerosis

Beattie, J. W.; Withey, J. L.

doi:10.1136/bmj.2.4833.414

Cited by 16 publications

(5 citation statements)

References 8 publications

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“…In any series of bone specimens from elderly patients, some can be expected to have abnormal osteoid estimations because of osteoporosis and possibly the early stages of osteitis deformans; case 9 had severe osteoporosis both histologically and radiologically. Oeschlin (1956) described an initial stage of myelosclerosis in which there was marked osteoclastic activity and this was also reported in one of the cases of Beattie and Withey (1953). In the present series the only evidence is possibly that of past osteoclastic activity from the irregular contour of the cement lines; no multinucleate osteoclasts were identified on bone surfaces.…”

Section: Discussionsupporting

confidence: 74%

Bone changes in polycythaemia vera and myelosclerosis

Roberts¹,

Woods²,

Miles³

et al. 1969

J Clin Pathol

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SYNOPSIS To study the problem of new bone formation in myelosclerosis bone biopsies have been performed in cases of polycythaemia vera, which may be regarded as a pre-myelosclerotic condition, and in primary myelosclerosis; morphological studies of bone and reticulin were made and osteoid and bone matrix was quantitatively assessed. Relevant metabolic studies were also carried out, but were predominantly normal. No new bone formation was detected in polycythaemia vera and some bone was osteoporotic; no significant increase in osteoid was found. With the use of polarized light it was found that new bone formation in myelosclerosis resulted from the ossification of wavy argyrophilic fibres in marrow: the presence of a dense network of these wavy fibres was a prerequisite of new bone formation and ossification of the non-refractile branched reticulin fibres was not observed.

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Section: Discussionsupporting

confidence: 74%

Bone changes in polycythaemia vera and myelosclerosis

Roberts¹,

Woods²,

Miles³

et al. 1969

J Clin Pathol

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“…LER was first described by Weil and Clerc at the beginning of the 20 th century in metastatic malignancies [5]. The term 'leukoerythroblastic' was coined by Vaughn in 1936; the synonyms of this term are leukemoid reaction with normoblasts and leukoerythroblastosis [6]. It is defined as a condition in which there is a presence of immature myeloid cells and nucleated red blood cells in the circulating blood [4].…”

Section: Discussionmentioning

confidence: 99%

“…It is defined as a condition in which there is a presence of immature myeloid cells and nucleated red blood cells in the circulating blood [4]. LER is most commonly seen in patients with metastatic malignancies, but Clifford was the first to describe it in conditions other than cancer, including hemolytic anemia, blood loss (acute or chronic), congestive heart failure, sepsis, megaloblastic anemia, and tuberculosis [5][6][7]. LER is usually not seen in viral infections, except for one study by Lemont et al in 2011 that showed LER can rarely be seen in parvovirus B19 infection [8].…”

Section: Discussionmentioning

confidence: 99%

Is a leukoerythroblastic blood picture common in COVID-19-positive adults?

et al. 2021

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“…In selected patients refractory to opioids, several cases in the literature describe meaningful palliation of pain with external radiation therapy. In the earliest published report of the merits of palliative external beam radiation therapy for MF-related bone pain, Beattie and Withey 28 described the case of a 48-year-old female diagnosed with polycythemia vera who received treatment to her femur and humerus. In 1979, Mason et al 10 described a 56-year-old man with MF who presented with severe lower extremity pain.…”

Section: Commentmentioning

confidence: 99%