Polydactylous Bowen's Disease in an Immunocompromised Patient: Resolution of All Lesions After Mohs Surgery on a Single Lesion

Goel, Nikita S.; Varma, Rajat; Zedek, Daniel C.; Jolly, Puneet S.

doi:10.1097/dss.0000000000001154

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 45 polydactylous cases were identified through the literature review, including the 1 case seen by the authors in the clinic (Table 1). 4,6 -38 There was a clear male predominance with 73.9% of cases reported in males and 23.9% reported in females ( P < .005). The age range at diagnosis was 21-80 years, with a mean age of 48.7 years.…”

Section: Resultsmentioning

confidence: 94%

Polydactylous Squamous Cell Carcinoma of the Nail Unit: A Structured Review of the Literature

Jedlowski

Segal

2020

J Cutan Med Surg

View full text Add to dashboard Cite

Squamous cell carcinoma of the nail unit (SCCNU) is a rare neoplastic condition that involves multiple digits (polydactylous SCCNU) in only 3.9% of cases. Here, we report a case of polydactylous SCCNU and perform a comprehensive review of MEDLINE and Embase to collate 44 cases of polydactylous SCCNU reported to date. Polydactylous patients were younger on average (48 to 61-63 years) and had a longer diagnostic delay (44 vs 35.1 months) compared with reported monodactylous cases. Human papillomavirus (HPV) positivity was observed in 49% of cases, and the most common serotypes noted were 16 (25.8%), 73 (16.1%), 58 (9.7%), 18 (6.5%), and 33 (6.5%). Twenty percent of the cases were in immunosuppressed individuals who had a statistically significant lower age at diagnosis (39.33 years vs 51.12 years; P = .01) and diagnostic delay (2.50 months vs 132.46 months, P = .04). Patients with HPV positivity had a lower age at diagnosis (43.74 years vs 53.29 years, P = .04). Environmental exposures noted to be associated with polydactylous disease included X-rays, paint/solvents, soluble oils, and stagnant water. This comprehensive literature review serves to characterize polydactylous SCCNU and distinguish the differences in its characteristics to improve diagnosis and clinical recognition.

show abstract

Section: Resultsmentioning

confidence: 94%

Polydactylous Squamous Cell Carcinoma of the Nail Unit: A Structured Review of the Literature

Jedlowski

Segal

2020

J Cutan Med Surg

View full text Add to dashboard Cite

show abstract

“…Multiple periungual Bowen’s disease is rare, with the most frequent risk factors being HPV infection and chronic immunosuppression [2]. Less than 10% of the cases present as longitudinal melanonychia [3].…”

Section: Discussionmentioning

confidence: 99%

Multiple-Digit Pigmented Bowen’s Disease Induced by Human Papillomavirus in an Immunocompetent Child

Guerrero-Gonzalez,

Di Chiacchio,

Paschoa

et al. 2023

Skin Appendage Disord

View full text Add to dashboard Cite

Introduction: Bowen’s disease is a squamous cell carcinoma in situ, the most common malignancy of the nail unit. Presenting more frequently in the fingernails, common risk factors include ionizing radiation, oral exposure to arsenic or pesticides, dyskeratosis congenita, and quite commonly diverse subtypes of HPV. We report the first case of multiple periungual pigmented Bowen’s disease in a pediatric patient. Case Presentation: A healthy 13-year-old boy presented with a 9-month history of a pigmented erythematous patch on the proximal nail fold of his 3rd right finger without associated symptoms. A punch biopsy was taken, and the diagnosis of Bowen’s disease was made. The patient received photodynamic therapy and three cycles of imiquimod without response, and two new lesions appeared on the first and second right fingers. Surgical removal was performed on all lesions. A polymerase chain reaction detected an HPV type 16. Discussion/Conclusion: Multiple periungual Bowen’s disease is rare, with the most frequent risk factors being HPV infection and chronic immunosuppression. Less than 10% of the cases present as longitudinal melanonychia. To date, there are no previous reports of multiple pigmented periungual Bowen’s disease. HPV-induced Bowen’s disease is usually present in adults aged between 22 and 89 years as persistent verrucae. In this case, koilocytosis and the fact that all lesions appeared on the right hand are suggestive of HPV infection.

show abstract

Polydactylous Bowen's Disease in an Immunocompromised Patient: Resolution of All Lesions After Mohs Surgery on a Single Lesion

Cited by 2 publications

References 5 publications

Polydactylous Squamous Cell Carcinoma of the Nail Unit: A Structured Review of the Literature

Polydactylous Squamous Cell Carcinoma of the Nail Unit: A Structured Review of the Literature

Multiple-Digit Pigmented Bowen’s Disease Induced by Human Papillomavirus in an Immunocompetent Child

Contact Info

Product

Resources

About