Polydeoxyribonucleotide injection in the patients with partial-thickness tear of supraspinatus tendon: a prospective and pilot study using ultrasound

Do, Hyun-Kyung; Lee, Joonghoon; Lim, Jae‐Young

doi:10.1080/00913847.2018.1450059

Cited by 7 publications

(13 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, a recent pilot study in 17 patients with RCT reported decreased shoulder pain and disabilities of the arm, hand, and shoulder, and improvements in forward flexion and internal rotation. 84 This is in agreement with a trial by Gervaso P. 85 showing that painful symptoms disappeared or were significantly reduced in a large (n = 138) cohort of patients with chronic tendinopathy treated weekly with PDRN by subcutaneous peritendon infiltration and daily by intramuscular administration.…”

Section: Pdrn and The Regulation Of Inflammation: Clinical Endpointssupporting

confidence: 91%

Polydeoxyribonucleotide Regulation of Inflammation

Colangelo

Galli

Guizzardi

2020

Advances in Wound Care

View full text Add to dashboard Cite

Significance: Dysregulated inflammation is a critical factor in the development of a wide range of diseases. Controlling inflammatory responses can be challenging because available treatment options are often limited. This review discusses the ability of polydeoxyribonucleotides (PDRN) to modulate inflammation and the evidence that supports it. Recent Advances: PDRN is known in the clinical field for its regenerative properties. This action is partially related to the stimulation of the purinergic system through adenosine A2A receptors (A2ARs). Recently, the topical antiinflammatory effects of PDRN have aroused much interest, with a growing body of research supporting its use for the management of several inflammatory states. Critical Issues: Impaired tissue repair and several metabolic disorders are associated with chronic inflammation. Despite the growing clinical concern, an optimal and sustainable therapy for different inflammatory conditions has not yet been established, and current treatments are often limited by their short-term efficacies and side effects. Future Directions: The present review provides an updated summary of the ability of PDRN to control inflammation as observed in several in vitro studies, simplified models of the main biological mechanisms mediating its anti-inflammatory effect, and confirmed in vivo and clinical models. It analyzes the therapeutic potential of PDRN in terms of its mechanism of action through A2AR activation, its efficacy and its complications compared with those of current anti-inflammatory drugs.

show abstract

Section: Pdrn and The Regulation Of Inflammation: Clinical Endpointssupporting

confidence: 91%

Polydeoxyribonucleotide Regulation of Inflammation

Colangelo

Galli

Guizzardi

2020

Advances in Wound Care

View full text Add to dashboard Cite

show abstract

“…Two studies hypothesized that Om-PDRN could be used as an efficient therapeutic agent for the treatment of posterior tibial tendon dysfunction and tendon tear [ 70 , 71 ]. In 2016, a study administered US-guided injections of Om-PDRN (1 vial, 5.625 mg/3 mL) to a 67-year-old woman experiencing pain along the inside of the foot and ankle at the site of the posterior tibial tendon [ 70 ].…”

Section: Resultsmentioning

confidence: 99%

“…At the final follow-up physical examination, the posterior tibial tendon exhibited no swelling and tenderness and there was a marked improvement in tendon strength. Another study investigated whether US-guided Om-PDRN injection could be used to safely treat a partially torn tendon [ 71 ]. Seventeen patients were subjected to US-guided injections into a well-defined and hypoechoic or anechoic area of the supraspinatus tendon for 4 weeks at 2-week intervals.…”

Section: Resultsmentioning

confidence: 99%

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Kim

Heo

et al. 2021

Marine Drugs

View full text Add to dashboard Cite

Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A2A receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.

show abstract

“…The other 3 studies included in our meta-analysis were assessed using the Newcastle-Ottawa scale: Yoon et al's studies [ 22 ] were rated as 9 stars, which indicate a low risk of bias (selection of subjects, 3 stars; comparability of groups, 3 stars; assessment of outcome, 3 stars). Do et al's [ 20 ] and Ryu et al's [ 19 ] studies were rated as 7 stars, which indicate a low risk of bias (selection of subjects, 3 stars; comparability of groups, 1 star; assessment of outcome, 3 stars).…”

Section: Resultsmentioning

confidence: 99%

“…An assessment of the remaining studies was conducted through a review of the full text of the articles. After a systematic review, 4 articles were included in the final analysis, which consisted of 1 RCT and 3 retrospective observational studies [19–22] . In the RCT by Kim et al, [21] patients in the control group received saline injections.…”

Section: Resultsmentioning

confidence: 99%

Does polydeoxyribonucleotide has an effect on patients with tendon or ligament pain?

et al. 2021

View full text Add to dashboard Cite

Background: Pain in the tendons or ligaments is extremely common, accounting for 30% of the causes of visiting general practitioners. Polydeoxyribonucleotide (PDRN) is emerging as a new treatment for musculoskeletal pain. However, the effects of PDRN in patients with tendon or ligament pain are unclear. Therefore, this study aimed to determine the impact of PDRN in patients with tendon or ligament pain through a meta-analysis. Methods: Electronic literature search of PubMed, Embase, SCOPUS, and Cochrane Library databases of all articles on PDRN treatment for patients with tendon or ligament pain published in the English language from inception until January 31, 2020. The search identified 262 citations. Results: One randomized controlled trial and 3 retrospective observational studies were included. Pain due to tendon or ligament disorders showed significant improvement after PDRN injection (standardized mean difference [SMD] = −1.43, 95% confidence interval [CI] = −1.80 to −1.06, P < .00001). In the subanalysis of patients with rotator cuff tendinopathy, rotator cuff tendinopathy-induced pain significantly improved (SMD = −2.34, 95% CI = −3.61 to −1.07, P = .0003) after PDRN injection. However, there was no difference in shoulder pain and disability index score and strength of shoulder abduction in patients with rotator cuff tendinopathy (shoulder pain and disability index score, SMD = 1.16, 95% CI = −1.20 to 3.52, P = .34; strength of shoulder abduction, SMD = 0.42, 95% CI = −0.03 to 0.88, P = .07). Conclusion: Effective pain relief was achieved in patients with tendon or ligament disorders after PDRN injection. To more precisely determine this effect, a meta-analysis with a larger number of clinical trials is warranted.

show abstract

Polydeoxyribonucleotide injection in the patients with partial-thickness tear of supraspinatus tendon: a prospective and pilot study using ultrasound

Abstract: Minimally invasive procedure through polydeoxynucleotide injection into torn area of supraspinatus tendon on US could be candidate for the safe and effective treatment on shoulder pain and limited range of motion in patients with rotator cuff tear.

Cited by 7 publications

References 45 publications

Polydeoxyribonucleotide Regulation of Inflammation

Polydeoxyribonucleotide Regulation of Inflammation

Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering

Does polydeoxyribonucleotide has an effect on patients with tendon or ligament pain?

Contact Info

Product

Resources

About