Polydiacetylene‐Peptide 1D Nanomaterials

Diegelmann, Stephen R.; Tovar, John D.

doi:10.1002/marc.201300423

Cited by 41 publications

(84 citation statements)

References 46 publications

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“…The interesting structural properties combined with the relatively facile functionalization make PA bres attractive structures to study. 16,[41][42][43][44][45] Systematic studies on assemblies of diacetylene containing amphiphiles elucidated the effect of several molecular parameters on the polymerisability of diacetylenes and the resulting polydiacetylene (PDA) absorption. 14 These aspects have been well investigated for peptide amphiphiles consisting of an alkyl tail coupled to a peptide moiety.…”

Section: Introductionmentioning

confidence: 99%

The influence of amino acid sequence on structure and morphology of polydiacetylene containing peptide fibres

et al. 2015

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A systematic study was performed on the influence of charge and steric hindrance on the assembly into fibres of a series of pentameric peptides based on the well-known β-sheet forming sequence Gly-Ala-Gly-Ala-Gly, which were N-terminally acylated with pentacosadiynoic acid. To investigate the effect of steric hindrance and charge repulsion on the fibre structure, either the N-terminal or the C-terminal amino acid in the sequence was replaced by a glutamic acid or lysine residue. Furthermore, peptide amphiphiles (PAs) with an amide or a free acid group at the C-terminus were compared. Steric hindrance and charge repulsion were addressed individually by varying the pH during and after fibre preparation. The self-assembled structures were examined with circular dichroism (CD) spectroscopy and transmission electron microscopy (TEM). UV spectroscopy was used to probe the diacetylene packing in the hydrophobic tail, both by polymerisation behaviour and chromatic properties of the polymers. In brief, the assembly was hindered more if the modification was close to the alkyl tail, and glutamic acid brought about a larger effect than lysine. PAs with two charges yielded assemblies which after polymerisation were found to be the most susceptible towards changes in pH, behaving as a colour-based pH sensor. Typically, TEM and UV showed the same trends, indicating that a distorted morphology as observed with TEM is indicative of a poorer molecular packing of the peptide amphiphile fibres, probed via the changes in absorption of the polydiacetylene backbone.

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Section: Introductionmentioning

confidence: 99%

The influence of amino acid sequence on structure and morphology of polydiacetylene containing peptide fibres

et al. 2015

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“…Polydiacetylenes (PDAs)1819202122232425262728 possess unique structural features that differ from those of other conjugated polymers. As they are prepared by polymerization of self-assembled diacetylene monomers (Fig.…”

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Hydrochromic conjugated polymers for human sweat pore mapping

et al. 2014

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Hydrochromic materials have been actively investigated in the context of humidity sensing and measuring water contents in organic solvents. Here we report a sensor system that undergoes a brilliant blue-to-red colour transition as well as ‘Turn-On’ fluorescence upon exposure to water. Introduction of a hygroscopic element into a supramolecularly assembled polydiacetylene results in a hydrochromic conjugated polymer that is rapidly responsive (<20 μs), spin-coatable and inkjet-compatible. Importantly, the hydrochromic sensor is found to be suitable for mapping human sweat pores. The exceedingly small quantities (sub-nanolitre) of water secreted from sweat pores are sufficient to promote an instantaneous colorimetric transition of the polymer. As a result, the sensor can be used to construct a precise map of active sweat pores on fingertips. The sensor technology, developed in this study, has the potential of serving as new method for fingerprint analysis and for the clinical diagnosis of malfunctioning sweat pores.

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“…59,60 The monomeric diacetylene precursor is known to undergo topochemical polymerization via 1,4-addition, provided that strict geometric requirements are achieved by the precursor crystal. 61 Frauenrath and co-workers developed a powerful system that uses hydrogen-bonded peptide regions to promote order among the diacetylene units and drives the polymerization within hydrogel or organogel networks. Their first generation peptide-PDA conjugates had poly(isoprene) units on one end which promotes solubility in organic solvents, tetra-L-alanine for anisotropic beta-sheet formation, and the diacetylene unit on the other end ( Figure 8a).…”

Section: Figure 5 Molecular Structures (A-c) and The Corresponding Nmentioning

confidence: 99%

Peptide π-Electron Conjugates: Organic Electronics for Biology?

2015

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Highly ordered arrays of π-conjugated molecules are often viewed as a prerequisite for effective charge-transporting materials. Studies involving these materials have traditionally focused on organic electronic devices, with more recent emphasis on biological systems. In order to facilitate the transition to biological environments, biomolecules that can promote hierarchical ordering and water solubility are often covalently appended to the π-electron unit. This review highlights recent work on π-conjugated systems bound to peptide moieties that exhibit self-assembly and aims to provide an overview on the development and emerging applications of peptide-based supramolecular π-electron systems.

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Polydiacetylene‐Peptide 1D Nanomaterials

Cited by 41 publications

References 46 publications

The influence of amino acid sequence on structure and morphology of polydiacetylene containing peptide fibres

The influence of amino acid sequence on structure and morphology of polydiacetylene containing peptide fibres

Hydrochromic conjugated polymers for human sweat pore mapping

Peptide π-Electron Conjugates: Organic Electronics for Biology?

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