Polydimethyl siloxane wet etching for three dimensional fabrication of microneedle array and high-aspect-ratio micropillars

Deng, Yu; Juang, Yi Je

doi:10.1063/1.4871038

Cited by 18 publications

(9 citation statements)

References 27 publications

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“…In addition, polymeric MN can be prepared using cost-effective and simple manufacturing methods, such as micromoulding-based technique [ 300 ]. Poly(dimethylsiloxane) (PDMS) or silicone elastomer are the most common materials for making MN moulds [ 310 ]. To prepare the PDMS mould, a master structure of the mould is required.…”

Section: Microneedlesmentioning

confidence: 99%

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Ramadon

McCrudden

Courtenay

et al. 2021

Drug Deliv. and Transl. Res.

284

159

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Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

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Section: Microneedlesmentioning

confidence: 99%

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Ramadon

McCrudden

Courtenay

et al. 2021

Drug Deliv. and Transl. Res.

284

159

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“…Nowadays, polymeric MNs have attracted great attention of researchers because most polymeric MNs are biocompatible and biodegradable to avoid harsh side effects in the skin, providing a safe device for the delivery of drugs. 30,104,112,123 Polymeric materials have been efficiently fabricated into solid MNs, coated MNs, dissolving MNs, and hollow MNs, including polymethyl methacrylate, 21,97,124 PLA, 55,94,112 polyglycolic acid, 101,98 polylactic-co-glycolic acid), 95,125 PVP, 22,54,104,126 polycaprolactone (PCL), 102,127 PVA, 103,105 and carboxymethyl cellulose (CMC). 106,128,129 However, most polymers are too soft to induce the buckling failure during the insertion process.…”

Section: Classified By Materials Of Mnsmentioning

confidence: 99%

“…Since the first concept of MN was proposed as a drug delivery device in a US patent in 1971 by Gerstel and Place, 16 the MNs have been developed for delivery of drugs over several decades. Now, MN has been explored into various structures (out-of-plane MNs and in-plane MNs), materials (silicon, ceramic, glass, metal, and polymer), geometries (octagonal, 15 cylindrical, 17 rectangular, 18 pyramidal, 11,19–21 conical, 22,23,24 and quadrangular 25 ), and morphologies, that is, solid MN (first reported in 1971 by Gerstel and Place 16 ), hollow MN (first reported in 1971 by Gerstel and Place 16 ), dissolving MN (first reported in 2005 by Miyano et al 26 ), and coated MN (first reported in a patent in 1975 by Pistor 27 ). Meanwhile, a variety of manufacturing techniques (such as etching, micromolding techniques, and lithography) for any MNs mentioned above, comprehensively considering the factors, including materials, structures, morphologies, geometry, and size, have also been reported in numbers of literatures.…”

Section: Introductionmentioning

confidence: 99%

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

et al. 2019

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Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for the morphologically, MNs can be classified into solid, coated, dissolved, and hollow MN, based on the transdermal drug delivery methods of “poke and patch,” “coat and poke,” “poke and release,” and “poke and flow,” respectively. Microneedles also have other characteristics based on the materials and structures. In addition, various manufacturing techniques have been well-developed based on the materials. In this review, the materials, structures, morphologies, and fabricating methods of MNs are summarized. A separate part of the review is used to illustrate the application of MNs to deliver vaccine, insulin, lidocaine, aspirin, and other drugs. Finally, the review ends up with a perspective on the challenges in research and development of MNs, envisioning the future development of MNs as the next generation of drug delivery system.

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“…[3][4][5][6][7][8][9][10][11][12][13] Li et al reported a microsystem for automated blood sampling from laboratory mice. 14 The proposed device, which consists of a microneedle, a reservoir, and an actuator, was designed to instantaneously prick the animal for a time-point sample.…”

Section: Introductionmentioning

confidence: 99%

Polymer-based disposable microneedle array with insertion assisted by vibrating motion

Lee

Hung

et al. 2016

Biomicrofluidics

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This work presents a disposable polymer-based microneedle array that carries out insertions by mimicking the vibrating motion of a mosquito's proboscis. The proposed device, which comprises a 10:1 high-aspect-ratio parylene microneedle array and a chamber structure, was monolithically realized using a novel fabrication process. The vibrating motion of the microneedles was generated using a piezoelectric actuator. This device can be potentially applied to extract and collect blood by puncturing the dermis layer of human skin. The fabricated device is advantageous because of its biocompatibility, simple fabrication process, and low associated costs. Additionally, the graph of the measured extraction flow rate versus the pressure drop that is presented shows an agreement with the results predicted by analytical models. A 40% reduction of insertion force was demonstrated when the microneedle insertion was assisted by actuator-induced vibratory motions. Buckling analyses for estimating the maximum loads that the microneedle can sustain before failure occurs were also evaluated. Finally, the relationship between the insertion force and the vibration frequency was demonstrated in this study. V C 2016 AIP Publishing LLC. [http://dx

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Polydimethyl siloxane wet etching for three dimensional fabrication of microneedle array and high-aspect-ratio micropillars

Cited by 18 publications

References 27 publications

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Polymer-based disposable microneedle array with insertion assisted by vibrating motion

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