Polydisperse low-density lipoproteins in hyperalphalipoproteinemic chronic alcohol drinkers in association with marked reduction of cholesteryl ester transfer protein activity

Hirano, Ken‐ichi; Matsuzawa, Yūji; Sakai, Naohiko; Hiraoka, Hisatoyo; Nozaki, Satoshi; Funahashi, Tohru; Yamashita, Shizuya; Kubo, Michinori; Tarui, Seiichiro

doi:10.1016/0026-0495(92)90101-f

Cited by 48 publications

(18 citation statements)

References 26 publications

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“…Individuals with a complete deficiency of CETP in plasma present with an abnormal distribution of LDL subclasses consisting of large and small LDL and a relative lack of the major intermediate LDL-I1 subclass as compared with controls (Sakai et al 1991). This pattern of LDL subclasses has also been found in heavy drinkers and is attributed to a marked inhibition of CETP activity by alcohol (Hirano et al 1992). Most importantly, acute abstention from alcohol results in a dramatic return of CETP activity and normalization of the LDL subclass profile, suggesting that CETP shuttles CE from large LDL-I and small LDL-I11 into the intermediate LDL-I1 (Figs.…”

Section: Lipid Transfer Reactions: Cholesteryl Ester Transfer Proteinssupporting

confidence: 61%

Low-density lipoprotein subclasses: mechanisms of formation and modulation

Griffin

1997

Proc. Nutr. Soc.

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Section: Lipid Transfer Reactions: Cholesteryl Ester Transfer Proteinssupporting

confidence: 61%

Low-density lipoprotein subclasses: mechanisms of formation and modulation

Griffin

1997

Proc. Nutr. Soc.

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“…Although their prevalence is unknown, missense mutations with a strong effect on HDL, together with a common splicing defect with mild effects on HDL (2-6), could result in genetic CETP deficiency states having a significant impact on the epidemiology of HDL in Japan. Genetic CETP deficiency might also interact synergistically with environmen-tal factors that decrease CETP, such as alcohol intake (23,24). A high frequency of genetic CETP deficiency states could reflect a biological advantage, such as the resistance to endotoxin conferred by increased HDL levels (25).…”

Section: Resultsmentioning

confidence: 99%

A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins.

Takahashi¹,

Jiang²,

Sakai³

et al. 1993

J. Clin. Invest.

132

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“…Thus, it is possible that retention of such triglyceride-rich LDL and subsequent lipolytic processing contributes to the heterogeneous LDL subclass profile found in patients with CETP deficiency. In heavy alcohol drinkers, multiple LDL species are observed on GGE with normalization upon abstention from alcohol and may be associated with secondary, partial CETP deficiency in these patients (117). Consistent with this notion is the observation that incubation of plasma containing "polydisperse" LDL with CETP can shift the LDL to a monodisperse pattern (118).…”

Section: Role Of Cholesteryl Ester Transfer Protein In the Metabolismmentioning

confidence: 86%

Metabolic origins and clinical significance of LDL heterogeneity

Berneis

Krauss

2002

Journal of Lipid Research

779

633

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LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from multiple pathways, including catabolism of different VLDL and IDL precursors, metabolic remodeling, and direct production. A common lipoprotein profile designated atherogenic lipoprotein phenotype is characterized by a predominance of small dense LDL particles. Multiple features of this phenotype, including increased levels of triglyceride rich lipoprotein remnants and IDLs, reduced levels of HDL and an association with insulin resistance, contribute to increased risk for coronary heart disease compared with individuals with a predominance of larger LDL. Increased atherogenic potential of small dense LDL is suggested by greater propensity for transport into the subendothelial space, increased binding to arterial proteoglycans, and susceptibility to oxidative modification. Large LDL particles also can be associated with increased coronary disease risk, particularly in the setting of normal or low triglyceride levels. Like small LDL, large LDL exhibits reduced LDL receptor affinity compared with intermediate sized LDL. Future delineation of the determinants of heterogeneity of LDL and other apoB-containing lipoproteins may contribute to improved identification and management of patients at high risk for atherosclerotic disease. -Berneis, K. K., and R. M. Krauss. Metabolic origins and clinical significance of LDL heterogeneity.

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Polydisperse low-density lipoproteins in hyperalphalipoproteinemic chronic alcohol drinkers in association with marked reduction of cholesteryl ester transfer protein activity

Cited by 48 publications

References 26 publications

Low-density lipoprotein subclasses: mechanisms of formation and modulation

Low-density lipoprotein subclasses: mechanisms of formation and modulation

A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins.

Metabolic origins and clinical significance of LDL heterogeneity

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