Polydopamine-assisted decoration of Se nanoparticles on curcumin-incorporated nanofiber matrices for localized synergistic tumor-wound therapy

Zhang, Meng; Zhang, Jiting; Ran, Siyi; Sun, Wei; Zhu, Zhihong

doi:10.1039/d1bm01607e

Cited by 18 publications

(11 citation statements)

References 63 publications

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“…4d). Mitochondria are known to be the best-characterized sources and primary target of intracellular ROS [42,43]. Increased intracellular ROS levels can adversely affect mitochondrial membrane integrity and associated transmembrane potential [44].…”

Section: Discussionmentioning

confidence: 99%

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Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy

Zhang

Ran

Yin

et al. 2022

Preprint

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Background Destruction of cellular redox homeostasis to induce cancer cell apoptosis is an emerging tumor therapeutic strategy. To achieve this goal, elevating exogenous oxidative stress or impairing the antioxidant defense system of cancer cells is an effective method. Herein, we firstly report a biocompatible and versatile nanoplatform (MpDA/Vc-Ca/PCM) based on calcium ascorbate (Vc-Ca) loaded mesoporous polydopamine (MpDA) nanoparticles, which simultaneously realized ROS generation, suppression of tumor antioxidant capability, and hyperthermia co-enhanced oncotherapy. Methods In this design, Vc-Ca is first loaded into MpDA, and then phase change material (PCM) is wrapped onto the surface of MpDA to form MpDA/Vc-Ca/PCM. The temperature-controlled release of Vc-Ca is characterized. The photothermal performance and GSH consumption capacity of MpDA are evaluated. The cytotoxicity mechanism of Vc-Ca is systematacially investigated. To confirm the synergistic tumor therapeutic effects, in vitro and in vivo biological tests are implemented. Results Vc-Ca encapsulated in MpDA by PCM is controllably released due to the melting of PCM matrix in response to photothermal heating upon a near-infrared irradiation. Vc-Ca is proved to be a pro-oxidant that can promote production of ROS (H2O2) in tumor site. Remarkably, MpDA can not only act as a photothermal agent, but also can break the redox balance of cancer cells through depleting the primary antioxidant glutathione (GSH), thus amplifying Vc-Ca-mediated oxidative therapy. Both in vitro and in vivo results demonstrate the significantly enhanced antitumor activity of boosted ROS combined with local hyperthermia. Conclusion This study highlights the potential applications of Vc-Ca in cancer treatment, and the prepared multifunctional nanoplatform provides a novel paradigm for high-efficiency oxidation-photothermal therapy.

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Section: Discussionmentioning

confidence: 99%

“…In general, the cell membrane damage caused by either apoptosis or necrosis would induce lactate dehydrogenase (LDH) releasing from the cytoplasm into the culture medium [34]. Here, the LDH activity in the corresponding culture medium of MG63 cells treated in different ways was detected.…”

Section: In Vitro Synergistic Anticancer Effectmentioning

confidence: 95%

Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy

Zhang

Ran

Yin

et al. 2022

Preprint

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“…A kind of PCL nanofiber that contained SeNPs, polydopamine (PDop), and CUR was prepared and evaluated for wound healing in tumor-bearing BALB/c nude mice. 47 The full-thickness wound was established on top of subcutaneous tumors of mice and was covered with asprepared nanofiber as wound dress as well as a drug delivery system. As well as interacting with SeNPs and immobilizing them in the nanofiber matrix, PDop act as a gatekeeper which causes the release of CUR in a sustained manner.…”

Section: Nanofibersmentioning

confidence: 99%

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

et al. 2023

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Despite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano‐CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR‐loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until the final stages of wound healing is more possible. Incorporating CUR‐loaded chitosan NPs into nanofiber increased the release time, while 80% of CUR was released during 240 h (10 days). Therefore, this system can guarantee the presence of CUR during the entire healing period. Furthermore, porous structures such as sponges, aerogels, some hydrogels, and scaffolds disclosed promising performance. These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three‐dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength.

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“…After 3 days, the cells in Fe−CuO showed more spindleshaped cell morphologies with green fluorescence than those in Fe and Fe−Cu groups, implying cell membrane integrity. 48,49 Moreover, the cells on Fe−CuO showed a more spread morphology with many filopodia and lamellipodia. 50,51 It could be deduced that the Fe−CuO composite was more favorable to cell spreading.…”

Section: Cytocompatibility Evaluationmentioning

confidence: 99%

Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant

Zeng

Yang

et al. 2022

ACS Biomater. Sci. Eng.

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Fe has immense potential for biodegradable orthopedic applications, but it degrades slowly in the physiological environment. Inducing galvanic couple by alloying Cu to Fe using ball milling is a promising approach. However, the ductile nature of Cu leads to the cold welding of a large amount of Cu powder during ball milling, which makes it difficult to disperse uniformly in the Fe matrix. Here, a Fe−CuO implant with highly dispersed Cu particles in the matrix was developed by shift-speed ball milling and selective laser melting. Specifically, copper oxide (CuO) particles were selected as precursors and dispersed in Fe powders by ball milling since they were brittle and would not be cold-welded during ball milling. After further milling in higher energy, it was found that CuO particles reacted with Fe and generated Cu particles through a stress-activated redox reaction. Subsequently, the obtained powders were prepared into a Fe−CuO implant using selective laser melting. Microstructure examination revealed that the Cu phases in the implant were dispersed evenly in the Fe matrix, which was considered to establish a large number of galvanic couples and aggravated the galvanic corrosion tendency. Electrochemical tests indicated that the implant had improved performance in degradation behavior in terms of high corrosion current density (22.4 μA/cm 2 ), low corrosion resistance (1319 Ω cm 2 ), and good degradation stability. In addition, it presented antibacterial effects against Escherichia coli and Staphylococcus aureus by diffusion mechanisms with killing rates of 90.7 and 96.7%, respectively, as well as good cytocompatibility.

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Polydopamine-assisted decoration of Se nanoparticles on curcumin-incorporated nanofiber matrices for localized synergistic tumor-wound therapy

Abstract: The management of surgical wounds incurred during tumor removal procedure has become a non-negligible issue. Herein, for the first time, an implantable polymer-based nanofiber matrix is developed for postoperative tumor...

Cited by 18 publications

References 63 publications

Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy

Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy

Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review

Highly Dispersed Cu Produced by Mechanical Stress-Activated Redox Reaction to Establish Galvanic Corrosion in Fe Implant

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