Polydopamine-assisted functionalization of heparin and vancomycin onto microarc-oxidized 3D printed porous Ti6Al4V for improved hemocompatibility, osteogenic and anti-infection potencies

Zhang, Teng; Zhou, Wenhao; Jia, Zhaojun; Wei, Qingguang; Fan, Daoyang; Yan, Jianglong; Yin, Cong; Cheng, Yan; Cai, Hong; Liu, Xiaoguang; Zhou, Hua; Yang, Xiaojie; Zheng, Yufeng; Liu, Zhongjun

doi:10.1007/s40843-017-9208-x

Cited by 36 publications

(21 citation statements)

References 53 publications

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“…Although the large bone defects were stably reconstructed by the individualized porous implants, local recurrence of the tumor or infection was found in some patients. Hence, in the future, we will apply anti-infection and anti-tumor functionalization technologies for the porous titanium alloy implants [ [44] , [45] , [46] , [47] , [48] ] to our “implant-bone” interface fusion method for better treatment of large bone defects.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional-printed individualized porous implants: A new “implant-bone” interface fusion concept for large bone defect treatment

Zhang

Wei

Zhou

et al. 2021

Bioactive Materials

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Bone defect repairs are based on bone graft fusion or replacement. Current large bone defect treatments are inadequate and lack of reliable technology. Therefore, we aimed to investigate a simple technique using three-dimensional (3D)-printed individualized porous implants without any bone grafts, osteoinductive agents, or surface biofunctionalization to treat large bone defects, and systematically study its long-term therapeutic effects and osseointegration characteristics. Twenty-six patients with large bone defects caused by tumor, infection, or trauma received treatment with individualized porous implants; among them, three typical cases underwent a detailed study. Additionally, a large segmental femur defect sheep model was used to study the osseointegration characteristics. Immediate and long-term biomechanical stability was achieved, and the animal study revealed that the bone grew into the pores with gradual remodeling, resulting in a long-term mechanically stable implant-bone complex. Advantages of 3D-printed microporous implants for the repair of bone defects included 1) that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility, and 2) that osseointegration between the host bone and implants was achieved without bone grafting. Our osseointegration method, in which the “implant-bone” interface fusion concept was used instead of “bone-bone” fusion, subverts the traditional idea of osseointegration.

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Section: Discussionmentioning

confidence: 99%

Three-dimensional-printed individualized porous implants: A new “implant-bone” interface fusion concept for large bone defect treatment

Zhang

Wei

Zhou

et al. 2021

Bioactive Materials

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“…Smooth Ti alloy beads loaded with antibiotics demonstrated a limited inhibition effect before the second day. The change in the surface topology also improved the release profile of antibiotics and significantly increased the release amount [107,123].…”

Section: Antibioticmentioning

confidence: 97%

“…TNT is easily adapted to AM porous structures and can be prepared on three-dimensional nonplanar surfaces [104]. A uniform layer of TNT can be formed on porous implants by liquid phase electrochemical treatment, e.g., anodizing [105,106] and micro-arc oxidation (MAO) [107][108][109]. In addition to the macroporous structure of AM technology, the microstructure of partially melted Ti microspheres on the surface of AM implants and TNT together constitutes a unique dual micro-to nanotopography (Figure 5) [110][111][112].…”

Section: Nanometer Coatingmentioning

confidence: 99%

Toward Bactericidal Enhancement of Additively Manufactured Titanium Implants

et al. 2021

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Implant-associated infections (IAIs) are among the most intractable and costly complications in implant surgery. They can lead to surgery failure, a high economic burden, and a decrease in patient quality of life. This manuscript is devoted to introducing current antimicrobial strategies for additively manufactured (AM) titanium (Ti) implants and fostering a better understanding in order to pave the way for potential modern high-throughput technologies. Most bactericidal strategies rely on implant structure design and surface modification. By means of rational structural design, the performance of AM Ti implants can be improved by maintaining a favorable balance between the mechanical, osteogenic, and antibacterial properties. This subject becomes even more important when working with complex geometries; therefore, it is necessary to select appropriate surface modification techniques, including both topological and chemical modification. Antibacterial active metal and antibiotic coatings are among the most commonly used chemical modifications in AM Ti implants. These surface modifications can successfully inhibit bacterial adhesion and biofilm formation, and bacterial apoptosis, leading to improved antibacterial properties. As a result of certain issues such as drug resistance and cytotoxicity, the development of novel and alternative antimicrobial strategies is urgently required. In this regard, the present review paper provides insights into the enhancement of bactericidal properties in AM Ti implants.

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“…Three-dimensional (3D) printing can readily fabricate complex 3D structures, which is hard to achieve by traditional processing methods [1,2]. Therefore, 3D printing has wide applications in various fields, such as electronics, biomedical engineering, energy industry, and aerospace [3][4][5][6][7][8][9][10][11][12][13][14]. There are many types of 3D printing technologies such as digital light processing (DLP), selective laser sintering (SLS), stereolithography (SLA), fused deposition modeling (FDM), and direct ink writing (DIW) [15,16].…”

Section: Introductionmentioning

confidence: 99%

Self-healing materials enable free-standing seamless large-scale 3D printing

et al. 2021

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Three-dimensional (3D) printing has had a large impact on various fields, with fused deposition modeling (FDM) being the most versatile and cost-effective 3D printing technology. However, FDM often requires sacrificial support structures, which significantly complicates the processing and increase the cost. Furthermore, poor layer-to-layer adhesion greatly affects the mechanical stability of 3D-printed objects. Here, we present a new Print-Healing strategy to address the aforementioned challenges. A polymer ink (Cu-DOU-CPU) with synergetic triple dynamic bonds was developed to have excellent printability and room-temperature self-healing ability. Objects with various shapes were printed using a simple compact 3D printer, and readily assembled into large sophisticated architectures via self-healing. Triple dynamic bonds induce strong binding between layers. Additionally, damaged printed objects can spontaneously heal, which significantly elongates their service life. This work paves a simple and powerful way to solve the key bottlenecks in FDM 3D printing, and will have diverse applications.

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Polydopamine-assisted functionalization of heparin and vancomycin onto microarc-oxidized 3D printed porous Ti6Al4V for improved hemocompatibility, osteogenic and anti-infection potencies

Cited by 36 publications

References 53 publications

Three-dimensional-printed individualized porous implants: A new “implant-bone” interface fusion concept for large bone defect treatment

Three-dimensional-printed individualized porous implants: A new “implant-bone” interface fusion concept for large bone defect treatment

Toward Bactericidal Enhancement of Additively Manufactured Titanium Implants

Self-healing materials enable free-standing seamless large-scale 3D printing

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