Polydopamine Biomaterials for Skin Regeneration

Abstract

Designing biomaterials capable of biomimicking wound healing and skin regeneration has been receiving increasing attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting biointerfacial adhesion and intrinsic cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer that endows high chemical versatility, making it an exciting candidate for a wide range of biomedical applications. Moreover, biomaterials based on PDA and its derivatives have near-infrared (NIR) absorption, excellent biocompatibility, intrinsic antioxidative activity, antibacterial activity, and cell affinity. PDA can regulate cell behavior by controlling signal transduction pathways. It governs the focal adhesion behavior of cells at the biomaterials interface. These features make melanin-like PDA a fascinating biomaterial for wound healing and skin regeneration. This paper overviews PDA-based biomaterials’ synthesis, properties, and interactions with biological entities. Furthermore, the utilization of PDA nano- and microstructures as a constituent of wound-dressing formulations is highlighted.

The effects of process parameters on polydopamine coatings employed in tissue engineering applications

“…Since the pros of PDA outweigh its cons, various groups of scientists have modified the biomaterials’ surfaces by employing PDA with the aim of augmenting their surface performance. Therefore, within the last couple of years, PDA has been in the spotlight, with diverse applications in the field of biomedical engineering ( Lynge et al, 2011 ), including drug delivery ( Huang et al, 2018 ), implants ( Jia et al, 2019 ), surface engineering ( Yang et al, 2015 ), cancer therapy ( Abdollahi et al, 2022 ; Honmane et al, 2022 ), TE (bone ( Huang et al, 2016 ; Kaushik et al, 2020 ), cartilage ( Huang et al, 2021 ), muscle ( Zhou et al, 2021 ), skin ( Yazdi et al, 2022 ), tendon ( Lin et al, 2019 ), and neuron ( Qian et al, 2018 ; Yan et al, 2020 )), and microfluidic systems ( Niculescu et al, 2021 ).…”

Balancing anti‐migration and anti‐aging behavior of binary antioxidants for high‐performance 1,2‐polybutadiene rubber

“…Marine mussels are famous for their superior ability for adhering to the surface of nanomaterials. [20][21][22] The strong adhesive Interface force could be attributed to mussel adhesive proteins. Inspired by this, a novel surface modification strategy had been developed by Lee et al 23 in 2007.…”

“…Marine mussels are famous for their superior ability for adhering to the surface of nanomaterials 20–22 . The strong adhesive Interface force could be attributed to mussel adhesive proteins.…”

Preparation and Characterization of Protein Molecularly Imprinted Poly (Ionic Liquid)/Calcium Alginate Composite Cryogel Membrane with High Mechanical Strength for the Separation of Bovine Serum Albumin

“…However, the development of protein molecular imprinting technology still confronts many challenges, mainly because of the intrinsic properties of proteins, such as the large size, structural variability, complex surface groups and easy denaturation and unfolding during the separation process [ 14 , 15 ]. To solve these problems, the molecularly imprinted hydrogel is a good choice, because the biocompatibility of the hydrogel-based system does not affect protein conformation and the macroporous structure of hydrogel can act as the passages of the proteins [ 15 , 16 , 17 ]. What is especially worth noting is that supermacropores can be formed in cryogels during frozen polymerization, which can allow a rapider and non-restricted mass-transport of proteins than common hydrogels [ 18 , 19 ].…”

“…The poor mechanical stability will limit the separation efficiency and the reusability of MIP. To enhance the mechanical strength, adding another component has been attempted [ 16 , 21 , 22 , 23 , 24 ], because the good mechanical property of the composite constructs can maintain the shape of the imprinted cavities to improve the regeneration properties of the hydrogels [ 22 , 23 ].…”