Polydopamine coated hollow mesoporous silica nanoparticles as pH-sensitive nanocarriers for overcoming multidrug resistance

Shao, Mengmeng; Chang, Cong; Liu, Zuhao; Chen, Kai; Zhou, Yimin; Zheng, Guohua; Huang, Zhijun; Xu, Haixing; Xu, Ping; Lü, Bo

doi:10.1016/j.colsurfb.2019.110427

Cited by 66 publications

(30 citation statements)

References 45 publications

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“…The platform fulfills innovative ideas for targeting cancer and improving therapy. In another attempt, polydopaminecoated hollow MSNs combining Dox hydrochloride with quercetin efficiently overcame multidrug resistance in taxol and Dox double-resistant human colorectal cancer cells (HCT-8/TAX cells) [371]. Fang et al [262] developed a hyaluronic acid-modified MSNs that co-deliver quercetin and Dox to enhance the efficacy of chemotherapy for gastric carcinoma.…”

Section: Quercetinmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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Natural prodrugs derived from different natural origins (e.g., medicinal plants, microbes, animals) have a long history in traditional medicine. They exhibit a broad range of pharmacological activities, including anticancer effects in vitro and in vivo. They have potential as safe, cost-effective treatments with few side effects, but are lacking in solubility, bioavailability, specific targeting and have short half-lives. These are barriers to clinical application. Nanomedicine has the potential to offer solutions to circumvent these limitations and allow the use of natural pro-drugs in cancer therapy. Mesoporous silica nanoparticles (MSNs) of various morphology have attracted considerable attention in the search for targeted drug delivery systems. MSNs are characterized by chemical stability, easy synthesis and functionalization, large surface area, tunable pore sizes and volumes, good biocompatibility, controlled drug release under different conditions, and high drug-loading capacity, enabling multifunctional purposes. In vivo pre-clinical evaluations, a significant majority of results indicate the safety profile of MSNs if they are synthesized in an optimized way. Here, we present an overview of synthesis methods, possible surface functionalization, cellular uptake, biodistribution, toxicity, loading strategies, delivery designs with controlled release, and cancer targeting and discuss the future of anticancer nanotechnology-based natural prodrug delivery systems.

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Section: Quercetinmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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“…have developed hybrid lipid‐capped MSNs as promising vehicles for doxorubicin (DOX) delivery to realize controlled drug release and overcome MDR 29 . Polydopamine‐coated hollow MSNs have also been explored as pH‐sensitive nanocarriers to reverse MDR and improve anticancer effects on taxol and DOX double‐resistant human colorectal cancer cells 30 . Recently, our research group and others have developed several controlled release formulations (CRFs) of pesticides using versatile MSNs as scaffolds 31–36 .…”

Section: Introductionmentioning

confidence: 99%

Indoxacarb‐loaded fluorescent mesoporous silica nanoparticles for effective control of Plutella xylostella L. with decreased detoxification enzymes activities

Bilal

Cao

et al. 2020

Pest Management Science

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BACKGROUND: Plutella xylostella L. is a cosmopolitan lepidopteron insect pest for numerous vegetables and crops. The extensive use of insecticides has resulted in the emergence of resistance in P. xylostella. Thus, development of innovative strategies to overcome the insecticide resistance and control P. xylostella effectively is highly desirable. Inspired by the concept and breakthrough of nanomedical strategies to treat multidrug resistance, nanotechnology may find potential application in overcoming or delaying insecticide resistance. RESULTS: Carbon dots-embedded fluorescent mesoporous silica nanoparticles (FL-SiO 2 NPs) were successfully developed. Indoxacarb-loaded nanoparticles (IN@FL-SiO 2 NPs) were facilely prepared with loading content of 24%. The release of indoxacarb from IN@FL-SiO 2 NPs was pH sensitive. IN@FL-SiO 2 NPs exhibited better insecticidal activity against P. xylostella than indoxacarb technical under the same doses of active ingredient applied. Moreover, the activities of detoxification enzymes including GST, CarE, and P450 of P. xylostella were suppressed by treatment with IN@FL-SiO 2 NPs. Furthermore, the entry of FL-SiO 2 NPs into the midgut of P. xylostella was confirmed by CLSM observation. CONCLUSIONS: Although there is no absolute correlation between the enzyme activity and resistance, the change in corresponding enzyme activity can afford valuable information on the resistance situation. IN@FL-SiO 2 NPs treated P. xylostella displayed higher mortality, along with decreased enzymes activities, which indicates that nano-based delivery system of insecticide could be potentially applied in insecticide resistance management.

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“…Specifically, the drug delivery system can control the drug release pattern and improve the accumulation of the drugs at targeting sites [ 71 , 73 ]. In this context, nanocarriers can achieve synergistic therapeutic effects and prove to have a stronger killing effect on cancer cells [ 74 ]. This can be seen in Alvandifar et al (2018), in a study that constructed poly-lactid-co-glycolide (PLGA) carriers using SN38, an active metabolite of irinotecan, and verapamil, a MDR1 reversal agent, and they obtained a good result in cellular uptake and reduction of cell viability on MDA-MB-231 breast cancer cell line [ 71 ].…”

Section: Resistance Of Nanocarriersmentioning

confidence: 99%

Nanocarriers Used in Drug Delivery to Enhance Immune System in Cancer Therapy

et al. 2021

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Cancer, a group of diseases responsible for the second largest cause of global death, is considered one of the main public health problems today. Despite the advances, there are still difficulties in the development of more efficient cancer therapies and fewer adverse effects for the patients. In this context, nanobiotechnology, a materials science on a nanometric scale specified for biology, has been developing and acquiring prominence for the synthesis of nanocarriers that provide a wide surface area in relation to volume, better drug delivery, and a maximization of therapeutic efficiency. Among these carriers, the ones that stand out are those focused on the activation of the immune system. The literature demonstrates the importance of this system for anticancer therapy, given that the best treatment for this disease also activates the immune system to recognize, track, and destroy all remaining tumor cells.

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Polydopamine coated hollow mesoporous silica nanoparticles as pH-sensitive nanocarriers for overcoming multidrug resistance

Cited by 66 publications

References 45 publications

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Indoxacarb‐loaded fluorescent mesoporous silica nanoparticles for effective control of Plutella xylostella L. with decreased detoxification enzymes activities

Nanocarriers Used in Drug Delivery to Enhance Immune System in Cancer Therapy

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