Polydopamine modification of silk fibroin membranes significantly promotes their wound healing effect

Zhang, Ying; Lu, Leihao; Chen, Yuping; Wang, Jie; Chen, Yu-Yin; Mao, Chuanbin; Yang, Mingying

doi:10.1039/c9bm00974d

Cited by 66 publications

(42 citation statements)

References 37 publications

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“…[ 29 ] Moreover, other authors have proposed the combination of silk and polydopamine by coating silk fibers in order to create an adhesive cement [ 30 ] or materials for wound dressing. [ 31 ]…”

Section: Resultsmentioning

confidence: 99%

Bioinspired Biomaterial Composite for All‐Water‐Based High‐Performance Adhesives

et al. 2021

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The exceptional underwater adhesive properties displayed by aquatic organisms, such as mussels (Mytilus spp.) and barnacles (Cirripedia spp.) have long inspired new approaches to adhesives with a superior performance both in wet and dry environments. Herein, a bioinspired adhesive composite that combines both adhesion mechanisms of mussels and barnacles through a blend of silk, polydopamine, and Fe3+ ions in an entirely organic, nontoxic water‐based formulation is presented. This approach seeks to recapitulate the two distinct mechanisms that underpin the adhesion properties of the Mytilus and Cirripedia, with the former secreting sticky proteinaceous filaments called byssus while the latter produces a strong proteic cement to ensure anchoring. The composite shows remarkable adhesive properties both in dry and wet conditions, favorably comparing to synthetic commercial glues and other adhesives based on natural polymers, with performance comparable to the best underwater adhesives with the additional advantage of having an entirely biological composition that requires no synthetic procedures or processing.

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Section: Resultsmentioning

confidence: 99%

Bioinspired Biomaterial Composite for All‐Water‐Based High‐Performance Adhesives

et al. 2021

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“…[ 64,65 ] As a sustainable and biocompatible protein, silk has been widely used in biomedicine and different tissue regenerations. [ 66–69 ] The in vivo studies revealed no significant infection for silk materials after the subcutaneous implantation. Both HFIP and aqueous derived silk scaffolds implanted subcutaneously in Lewis rats showed negligible immune response without detectable overexpression of the inflammation‐related genes containing TNF‐ α , interferon‐ γ , IL‐6, IL‐4, and interleukin‐13.…”

Section: Characteristics Of Silk As Biomaterialsmentioning

confidence: 99%

Silk Biomaterials for Bone Tissue Engineering

Ding

Cheng

Mia

et al. 2021

Macromolecular Bioscience

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Silk is a natural fibrous polymer with application potential in regenerative medicine. Increasing interest remains for silk materials in bone tissue engineering due to their characteristics in biocompatibility, biodegradability and mechanical properties. Plenty of the in vitro and in vivo studies confirmed the advantages of silk in accelerating bone regeneration. Silk is processed into scaffolds, hydrogels, and films to facilitate different bone regenerative applications. Bioactive factors such as growth factors and drugs, and stem cells are introduced to silk‐based matrices to create friendly and osteogenic microenvironments, directing cell behaviors and bone regeneration. The recent progress in silk‐based bone biomaterials is discussed and focused on different fabrication and functionalization methods related to osteogenesis. The challenges and potential targets of silk bone materials are highlighted to evaluate the future development of silk‐based bone materials.

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“…PDA coating has been widely used to improve the healing properties of SF membranes. PDA can be easily deposed on SF membranes by merely soaking the electrospun membranes in a DA solution under specific conditions [ 111 , 112 ]. The coat did not critically affect the structure and architecture of the fibers but increased the fibers’ hydrophilicity and adhesiveness [ 111 ], resulting in a better attachment and spreading of cells together with an increase in proliferation rate.…”

Section: Melanins and Melanin-like Materials In Tissue Engineeringmentioning

confidence: 99%

“…PDA can be easily deposed on SF membranes by merely soaking the electrospun membranes in a DA solution under specific conditions [ 111 , 112 ]. The coat did not critically affect the structure and architecture of the fibers but increased the fibers’ hydrophilicity and adhesiveness [ 111 ], resulting in a better attachment and spreading of cells together with an increase in proliferation rate. Moreover, in vivo experiments on full-thickness wound models, demonstrated that the PDA coating accelerated the healing process in comparison with uncoated membranes by providing a more adhesive surface and moist environment.…”

Section: Melanins and Melanin-like Materials In Tissue Engineeringmentioning

confidence: 99%

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

et al. 2020

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Melanins are a group of dark insoluble pigments found widespread in nature. In mammals, the brown-black eumelanins and the reddish-yellow pheomelanins are the main determinants of skin, hair, and eye pigmentation and play a significant role in photoprotection as well as in many biological functions ensuring homeostasis. Due to their broad-spectrum light absorption, radical scavenging, electric conductivity, and paramagnetic behavior, eumelanins are widely studied in the biomedical field. The continuing advancements in the development of biomimetic design strategies offer novel opportunities toward specifically engineered multifunctional biomaterials for regenerative medicine. Melanin and melanin-like coatings have been shown to increase cell attachment and proliferation on different substrates and to promote and ameliorate skin, bone, and nerve defect healing in several in vivo models. Herein, the state of the art and future perspectives of melanins as promising bioinspired platforms for natural regeneration processes are highlighted and discussed.

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Polydopamine modification of silk fibroin membranes significantly promotes their wound healing effect

Abstract: Natural polymer-based wound dressings have gained great attention in skin tissue engineering.

Cited by 66 publications

References 37 publications

Bioinspired Biomaterial Composite for All‐Water‐Based High‐Performance Adhesives

Bioinspired Biomaterial Composite for All‐Water‐Based High‐Performance Adhesives

Silk Biomaterials for Bone Tissue Engineering

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

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