Polyelectrolyte complex nanoparticles from cationised gelatin and sodium alginate for curcumin delivery

Sarika, P.R.; James, Nirmala Rachel

doi:10.1016/j.carbpol.2016.04.073

Cited by 159 publications

(60 citation statements)

References 36 publications

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“…A few articles have been reported the combination of SA and GE for controlled drug delivery [34][35][36][37], but as per best of our knowledge, the use of SA/GE/KA microbeads for controlled release of D-PA has not yet been investigated. In this research paper KA intercalated SA/GE microbeads were prepared.…”

Section: Introductionmentioning

confidence: 99%

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

et al. 2019

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Objective: The aim of the present study was to fabricate and evaluate the drug release studies using Sodium Alginate (SA) and Gelatin (GE) microbeads intercalated with Kaolin (KA) nanoclay for sustained release of D-Penicillamine (D-PA). Methods: Sodium alginate/gelatin/Kaolin blend microbeads were prepared by an extrusion method by using glutaraldehyde (GA) as a crosslinker. The obtained microbeads were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and X–ray diffraction (XRD). Drug release kinetics of the microbeads was investigated in simulated intestinal fluid (pH 7.4) at 37 °C. Results: Microbeads formation was confirmed by FTIR spectroscopy. X-RD reveals that the KA should be intercalated with the drug and also it confirms the molecular level dispersion of D-Penicillamine into microbeads. Scanning Electron Microscopy (SEM) studies reveal that the beads were in spherical shape with some wrinkled depressions on the surface. The in vitro release study indicates the D-Penicillamine released in a controlled manner. The in vitro release kinetics was assessed by Korsmeyer-Peppas equation and the ‘n’ value lies in between 0.557-0.693 indicates Non-Fickian diffusion process. Conclusion: The results suggest that the developed KA intercalated microbeads are good potential drug carrier for the controlled release of D-PA.

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Section: Introductionmentioning

confidence: 99%

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

et al. 2019

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“…Probably, at these concentrations due to depletion flocculation, the large aggregates form (Syrbe, Bauer, & Klostermeyer, ). Sarika and James () reported that when cationized gelatin and sodium alginate at high concentrations (0.2% w/w) were used, microparticles are formed instead of nanoparticle. According to Figure a, at constant value of CP (0.2%, w/v), by decreasing BG concentration, the particle size reduction was observed.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, it is biodegradable, biocompatible and non-immunogenic biopolymer. It can be used in food ingredient delivery systems due to its ability to form polyelectrolyte complex with both cationic and anionic polysaccharides (Mahor et al, 2016;Sarika & James, 2016;Sarika, Pavithran, & James, 2015).…”

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confidence: 99%

Design, fabrication and characterization of pectin-coated gelatin nanoparticles as potential nano-carrier system

et al. 2018

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The main purpose of this study was to fabricate potential nano‐delivery systems based on protein–polysaccharide complex for use in beverages. In this regard, optimum gelatin–pectin complex (GPC) nano‐carrier with hydrodynamic diameter of ≈200 nm was designed and fabricated using low‐bloom gelatin (BG) and high‐methoxyl pectin (CP) at BG/CP weight ratio of 1:1 (0.025%(w/v) CP on 0.025%(w/v) BG) and pH 4.5. The suspension containing GPC nano‐carrier had very good transparency (14.1NTU). Scanning electron microscopy (SEM) images illustrated that the GPC particles were spherical with fairly smooth surface. Particle size analysis showed that the complex particles had a narrow size distribution (polydispersity index (PDI)≈0.254). Fourier transform infrared (FTIR) confirmed the formation of amide bonds between carboxyl groups in CP and amino groups in BG, and differential scanning calorimetry (DSC) analysis showed the amorphous nature of the GPC nano‐carrier. Finally, the storage stability test indicated that the GPC particles didn't significantly grow after 20 days of storage at 4°C. Practical application The encapsulation of bioactive compounds have different benefits, for example, protection from several damaging environmental factors such as light, oxygen, moisture, heat, mechanical stresses, or other destructive agents, controlling the release of bioactives within foods during storage and also in human gastrointestinal tract, increase in solubility in aqueous foods and covering unfavorable flavor and odor of bioactive ingredients. So that, development of this technic can develops new functional, healthy foods, and foods with new tastes.

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“…James and co‐workers prepared hybrid polyelectrolyte nanoparticles from cationically modified gelatin and anionic sodium ALG. They investigated suitability of the nanoparticles for curcumin encapsulation and delivery to cancer cells.…”

Section: Alginate Nanoparticlesmentioning

confidence: 99%

Polysaccharide Based Nanoparticles

Khan

Abtew

Modani

et al. 2018

Israel Journal of Chemistry

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Nanoparticles made of biodegradable polymers have outstanding merits as a drug delivery system. Polysaccharide-based nanoparticles have been well explored because of their safety, stability, biocompatibility, biodegradability and hydrophilicity. The present review emphasizes the efforts articulated to improve polysaccharide-based nano-particles as drug delivery tool for effective therapy and sitespecific targeting of mainly anticancer agents. This review updates reports of recent research on polysaccharides-based systems particularly chitosan, alginate, cyclodextrins, hyaluronic acid, pullulan, dextran and their combinations with potential applications.

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Polyelectrolyte complex nanoparticles from cationised gelatin and sodium alginate for curcumin delivery

Cited by 159 publications

References 36 publications

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

Design, fabrication and characterization of pectin-coated gelatin nanoparticles as potential nano-carrier system

Polysaccharide Based Nanoparticles

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