Polyelectrolyte complexes as prospective carriers for the oral delivery of protein therapeutics

Bourganis, Vassilis; Karamanidou, Theodora; Kammona, Olga; Kiparissides, Costas

doi:10.1016/j.ejpb.2016.11.005

Cited by 71 publications

(42 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Controlled delivery has become an essential field of research for the design of systems able to liberate a cargo upon the application of specific stimuli, as stimuli‐responsive systems allow to minimize side effects caused by non‐controlled administration . Traditionally, the delivery systems were based on polymers that released the cargo by diffusion‐controlled processes or through degradation of the polymer container . In the last years, porous hybrid organic‐inorganic materials have merged as a noteworthy and large class of materials .…”

Section: Methodsmentioning

confidence: 99%

“…[1] Traditionally, the delivery systems were based on polymers that released the cargo by diffusion-controlled processes or through degradation of the polymer container. [2,3] In the last years, porous hybrid organic-inorganic materials have merged as a noteworthy and large class of materials. [4][5][6][7] These materials show high surface area, tunable pore size and versatility in their framework composition, which confer them an outstanding performance in many fields such as drug delivery, species adsorption and sensing applications among others.…”

mentioning

confidence: 99%

See 1 more Smart Citation

New Oleic Acid‐Capped Mesoporous Silica Particles as Surfactant‐Responsive Delivery Systems

et al. 2019

View full text Add to dashboard Cite

A new delivery microdevice, based on hydrophobic oleic acid‐capped mesoporous silica particles and able to payload release in the presence of surfactants, has been developed. The oleic acid functionalization confers to the system a high hydrophobic character, which avoids cargo release unless surfactant molecules are present. The performance of this oleic‐acid capped microdevice in the presence of different surfactants is presented and its zero‐release operation in the absence of surfactants is demonstrated.

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

New Oleic Acid‐Capped Mesoporous Silica Particles as Surfactant‐Responsive Delivery Systems

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The composition of precipitant salt containing weak anions resulted in high PDI particles. [32,33] Hu et al developed a chitosan-based PEC delivery system consisting of carboxymethyl pachyman (CMP) and CS. To improve the cellular up and permeation of protein both in vitro and in vivo, Zhang and coworkers introduced arginine-rich cell-penetrating lipopeptides (SAR6EW) and synthesized SAR6EW/CS/insulin loaded NPs.…”

Section: Strategies For Intracellular Protein Deliverymentioning

confidence: 99%

“…It has proven to be a simple and mild method to fabricate protein delivered NPs as it does not require organic solvents or sonication, thus can provide protection to the encapsulated proteins. [32,33] Hu et al developed a chitosan-based PEC delivery system consisting of carboxymethyl pachyman (CMP) and CS. [34] CMP is negatively charged polysaccharides which could interact with CS to form CMP/CS NPs through PEC method.…”

Section: Strategies For Intracellular Protein Deliverymentioning

confidence: 99%

Rational Design of Nanocarriers for Intracellular Protein Delivery

et al. 2019

View full text Add to dashboard Cite

Protein/antibody therapeutics have exhibited the advantages of high specificity and activity even at an extremely low concentration compared to small molecule drugs. However, they are accompanied by unfavorable physicochemical properties such as fragile tertiary structure, large molecular size, and poor penetration of the membrane, and thus the clinical use of protein drugs is hindered by inefficient delivery of proteins into the host cells. To overcome the challenges associated with protein therapeutics and enhance their biopharmaceutical applications, various protein‐loaded nanocarriers with desired functions, such as lipid nanocapsules, polymeric nanoparticles, inorganic nanoparticles, and peptides, are developed. In this review, the different strategies for intracellular delivery of proteins are comprehensively summarized. Their designed routes, mechanisms of action, and potential therapeutics in live cells or in vivo are discussed in detail. Furthermore, the perspective on the new generation of delivery systems toward the emerging area of protein‐based therapeutics is presented as well.

show abstract

“…For example, Sarmento and coworkers prepared insulin-loaded PECs using chitosan and dextran sulfate polysaccharides (Sarmento et al, 2006). The formation of colloidal polyelectrolyte complexes (PECs) seems to be a promising strategy for protein delivery to the target cells resulting in enhanced bioavailability (Bourganis et al, 2017). The oral administration of protein therapeutics was inhibited by several barriers in the gastrointestinal tract (GIT) such as acidic environment, proteolytic degradation and mucosal barrier.…”

Section: Colloidal Polyelectrolyte Complexes (Pecs) For Oral Protein mentioning

confidence: 99%

Improvements in chemical carriers of proteins and peptides

Bolhassani

2019

Cell Biology International

View full text Add to dashboard Cite

The successful intracellular delivery of biologically active proteins and peptides plays an important role for therapeutic applications. Indeed, protein/peptide delivery could overcome some problems of gene therapy, for example, controlling the expression levels and the integration of transgene into the host cell genome. Thus, protein/peptide drug delivery showed a promising and safe approach for treatment of cancer and infectious diseases. Due to the unique physical and chemical properties of proteins, their production (e.g., isolation, purification & formulation) and delivery represented significant challenges in pharmaceutical studies. Modification in the structural moieties of these protein/peptide drugs could improve their solubility, stability, crystallinity, lipophilicity, enzymatic susceptibility and targetability, and subsequently, therapies and cures against various diseases. Using the structural modification of protein/peptide, their delivery provided overall higher success rates including high specificity, high activity, bioreactivity and safety. Recently, biotechnological and pharmaceutical companies have tried to find novel techniques for the modifications and improve delivery systems/carriers. However, each carrier has its own benefits and drawbacks, and an appropriate carrier is often established by the physicochemical properties of protein or peptide, the ideal route of injection, and clinical characteristics of therapy. In this review, an attempt was made to give an overview on the chemical carriers for proteins and peptides as well as the recent advances in this field.

show abstract

Polyelectrolyte complexes as prospective carriers for the oral delivery of protein therapeutics

Cited by 71 publications

References 112 publications

New Oleic Acid‐Capped Mesoporous Silica Particles as Surfactant‐Responsive Delivery Systems

New Oleic Acid‐Capped Mesoporous Silica Particles as Surfactant‐Responsive Delivery Systems

Rational Design of Nanocarriers for Intracellular Protein Delivery

Improvements in chemical carriers of proteins and peptides

Contact Info

Product

Resources

About