Polyelectrolyte Complexes Based on (Quaternized) Poly[(2‐dimethylamino)ethyl methacrylate]: Behavior in Contact with Blood

Yancheva, Elena; Paneva, Dilyana; Danchev, D.; Mespouille, Laetitia; Dubois, Philippe; Manolova, Nevena; Rashkov, Iliya

doi:10.1002/mabi.200700056

Cited by 30 publications

(37 citation statements)

References 27 publications

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“…These results suggest that PP may be required above a critical level to significantly shorten the lag time for initial thrombin generation and lead to faster platelet activation and adhesion [31]. Alternately, complexes containing different proportions of PP may have different surface charge distributions, which affected electrostatic interaction with plasma proteins and in turn affected platelet binding and subsequent activation [32].…”

Section: Discussionmentioning

confidence: 96%

Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties

et al. 2008

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Section: Discussionmentioning

confidence: 96%

Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties

et al. 2008

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“…The permeabilisation of the outer membrane by pDMAEMA appears to remove the barrier for the antibiotic, In order to use pDMAEMA as an antimicrobial coating or treatment, it must be shown to be safe to humans. Reports on the cytotoxicity of pDMAEMA vary depending on the method of administration, quaternisation of the polymer, other polymers attached and size [65][66][67][68] . Moreau et al 65 found that pDMAEMA caused little or no haemolysis to human red blood cells however, when injected intravenously into the tail vein of rats caused death at 5.1 mg/kg but was tolerated at 2.1 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Effects of Poly(2-(dimethylamino ethyl)methacrylate) against Selected Gram-Positive and Gram-Negative Bacteria

et al. 2009

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Antimicrobial coatings can reduce the occurrence of medical device-related bacterial infections. Poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is one such polymer that is being researched in this regard. The aims of this study were to (1) elucidate pDMAEMA’s antimicrobial activity against a range of Gram-positive and Gram-negative bacteria and (2) to investigate its antimicrobial mode of action. The methods used include determination of minimum inhibitory concentration (MIC) values against various bacteria and the effect of pH and temperature on antimicrobial activity. The ability of pDMAEMA to permeabilise bacterial membranes was determined using the dyes 1-N-phenyl-naphthylamine and calcein-AM. Flow cytometry was used to investigate pDMAEMA’s capacity to be internalized by bacteria and to determine effects on bacterial cell cycling. pDMAEMA was bacteriostatic against Gram-negative bacteria with MIC values between 0.1−1 mg/mL. MIC values against Gram-positive bacteria were variable. pDMAEMA was active against Gram-positive bacteria around its pK a and at lower pH values, while it was active against Gram-negative bacteria around its pK a and at higher pH values. pDMAEMA inhibited bacterial growth by binding to the outside of the bacteria, permeabilizing the outer membrane and disrupting the cytoplasmic membrane. By incorporating pDMAEMA with erythromycin, it was found that the efficacy of the latter was increased against Gram-negative bacteria. Together, the results illustrate that pDMAEMA acts in a similar fashion to other cationic biocides.

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“…Namely, PAMPSA was shown to act against blood clotting in a similar way to heparin, either alone 15 or incorporated in copolymers. 16 Setoyama et al…”

Section: Introductionmentioning

confidence: 99%

Stem cell differentiation on conducting polyaniline

et al. 2015

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Polyaniline is a promising conducting polymer with broad application potential in biomedicine. Its medical use, however, requires both biocompatibility and suitable physico-chemical and surface properties. The microstructure, electrical properties, and surface characteristics of polyaniline salt, polyaniline base, and polyaniline deposited with biologically active poly(2-acrylamido-2-methyl-1-propanesulfonic acid) were revealed using atomic force microscopy, contact angle measurements, and Raman spectroscopy. As conducting polymers can be preferentially applied in tissue engineering of heart and nervous tissues, the cardiomyogenesis in pure cardiomyocytes derived from embryonic stem cells and neurogenesis in neural progenitors isolated from embryonal 13 dpc brain were further investigated. The results show that neither cardiomyogenesis nor neurogenesis were influenced by any of the tested polyaniline films.However, the most favorable cell behaviour was observed on pristine polyaniline base; therefore, polyaniline in pristine forms without any further modification can be applied in a variety of biomedical fields.

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Polyelectrolyte Complexes Based on (Quaternized) Poly[(2‐dimethylamino)ethyl methacrylate]: Behavior in Contact with Blood

Cited by 30 publications

References 27 publications

Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties

Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties

Antibacterial Effects of Poly(2-(dimethylamino ethyl)methacrylate) against Selected Gram-Positive and Gram-Negative Bacteria

Stem cell differentiation on conducting polyaniline

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