Polyelectrolyte Parg/DS submicrocapsules functionalized by magnetite nanoparticles as effective MR contrast agents

Kozlova, Anastasiia; German, Sergey V.; Новоселова, М. В.; Demina, Polina A.; Atkin, Vsevolod S.; Зуев, В. В.; Gorin, Dmitry A.

doi:10.1088/1742-6596/1092/1/012067

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…They served as a very good absorber in the NIR region and provided strong enhancement of photoacoustic imaging modality in both water and blood. Parg/DS microcapsules functionalized with Fe 3 O 4 NPs have proved to be effective magnetic resonance contrast agents [177]. Low frequency alternating magnetic fields have also proven effective in inducing subtle changes in doxycycline release from PAH/PSS/Fe 3 O 4 microcapsules without inflicting damage to the cells after 30 min of exposure [178].…”

Section: Medical Imagingmentioning

confidence: 99%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

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Multilayer capsules have been of great interest for scientists and medical communities in multidisciplinary fields of research, such as drug delivery, sensing, biomedicine, theranostics and gene therapy. The most essential attributes of a drug delivery system are considered to be multi-functionality and stimuli responsiveness against a range of external and internal stimuli. Apart from the highly explored strong polyelectrolytes, weak polyelectrolytes offer great versatility with a highly controllable architecture, unique stimuli responsiveness and easy tuning of the properties for intracellular delivery of cargo. This review describes the progress in the preparation, functionalization and applications of capsules made of weak polyelectrolytes or their combination with biopolymers. The selection of a sacrificial template for capsule formation, the driving forces involved, the encapsulation of a variety of cargo and release based on different internal and external stimuli have also been addressed. We describe recent perspectives and obstacles of weak polyelectrolyte/biopolymer systems in applications such as therapeutics, biosensing, bioimaging, bioreactors, vaccination, tissue engineering and gene delivery. This review gives an emerging outlook on the advantages and unique responsiveness of weak polyelectrolyte based systems that can enable their widespread use in potential applications.

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Section: Medical Imagingmentioning

confidence: 99%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

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Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors

Svenskaya¹,

Garello²,

Lengert³

et al. 2021

Nanotheranostics

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Rationale: The tireless research for effective drug delivery approaches is prompted by poor target tissue penetration and limited selectivity against diseased cells. To overcome these issues, various nano- and micro-carriers have been developed so far, but some of them are characterized by slow degradation time, thus hampering repeated drug administrations. The aim of this study was to pursue a selective delivery of magnetic biodegradable polyelectrolyte capsules in a mouse breast cancer model, using an external magnetic field. Methods: Four different kinds of magnetic polyelectrolyte capsules were fabricated via layer-by-layer assembly of biodegradable polymers on calcium carbonate templates. Magnetite nanoparticles were embedded either into the capsules' shell (sample S) or both into the shell and the inner volume of the capsules (samples C n S, where n is the number of nanoparticle loading cycles). Samples were first characterized in terms of their relaxometric and photosedimentometric properties. In vitro magnetic resonance imaging (MRI) experiments, carried out on RAW 264.7 cells, allowed the selection of two lead samples that proceeded for the in vivo testing on a mouse breast cancer model. In the set of in vivo experiments, an external magnet was applied for 1 hour following the intravenous injection of the capsules to improve their delivery to tumor, and MRI scans were acquired at different time points post administration. Results: All samples were considered non-cytotoxic as they provided more than 76% viability of RAW 264.7 cells upon 2 h incubation. Sample S appeared to be the most efficient in terms of T 2 -MRI contrast, but the less sensitive to external magnet navigation, since no difference in MRI signal with and without the magnet was observed. On the other side, sample C 6 S was efficiently delivered to the tumor tissue, with a three-fold T 2 -MRI contrast enhancement upon the external magnet application. The effective magnetic targeting of C 6 S capsules was also confirmed by the reduction in T 2 -MRI contrast in spleen if compared with the untreated with magnet mice values, and the presence of dense and clustered iron aggregates in tumor histology sections even 48 h after the magnetic targeting. Conclusion: The highlighted strategy of magnetic biodegradable polyelectrolyte capsules' design allows for the development of an efficient drug delivery system, which through an MRI-guided externally controlled navigation may lead to a significant improvement of the anticancer chemotherapy performance.

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Polyelectrolyte Parg/DS submicrocapsules functionalized by magnetite nanoparticles as effective MR contrast agents

Cited by 2 publications

References 8 publications

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors

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