Polyethylene glycol improves elution properties of polymethyl methacrylate bone cements

Handal, John A.; Tiedeken, Nathan C.; Gershkovich, Grigory; Kushner, Jeffrey; Dratch, Benjamin; Samuel, Solomon Praveen

doi:10.1016/j.jss.2014.10.051

Cited by 13 publications

(5 citation statements)

References 23 publications

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“…Currently, researchers focused on developing novel biomaterials that promoted osteogenesis to facilitate bone recover in patients with non-self-healing bone defects, 34–36 and recent studies reported that polyethylene glycol two acrylate (PEGDA) was one of the effective biomaterials for bone recovery. 37–39 In addition, Exendin4 played an important role in regulating osteogenic differentiation, 40–42 which encouraged us to create PEGDA-loading Exendin4 for potential utilization. Based on the above information, the bone tissue analysis results in this study showed that, compared with PEGDA, the volume of bone treated by mineralized gel was significantly higher in Exendin4-PEGDA and PEGDA group, and the bone volume in the drug loading group was higher than that in the nondrug loaded group.…”

Section: Discussionmentioning

confidence: 99%

PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

Liu

Jing

et al. 2021

J Biomater Appl

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Scaffolds with osteogenic differentiation function play an important role in the healing process of bone defects. Here, we designed a high strength Poly(ethyleneglycol) diacrylate/Hydroxyapatite (PEGDA/HA) mineralized hydrogel loaded with Exendin4 for inducing osteogenic differentiation. In this study, PEGDA hydrogel was prepared by photo initiating method. PEGDA/HA mineralized hydrogel was prepared by in-situ precipitation method, and Exendin4 was loaded by gel adsorption. The effects of different calcium and phosphorus concentrations on the strength and Exendin4 release of PEGDA/HA hydrogels were investigated. Rat models of bone defect were made and randomly divided into 5 groups. The experimental group was implanted with PEGDA hydrogel, Exendin4-PEGDA hydrogel, PEGDA/HA mineralized hydrogel, Exendin4-PEGDA/HA mineralized hydrogel, and no materials were implanted in the blank control group. Computed tomography (CT) and histology were observed 4 and 8 weeks after operation. Our results revealed that the PEGDA/HA mineralized hydrogel had porous structure, high mechanical strength and good biocompatibility. In vitro release test showed that the mineralized hydrogel exhibited good sustained release profile within 20 d. The animal experiments showed that the mineralized hydrogel accelerated the formation of new bone after 4 and 8 weeks, and formed a seamless union on the defected bone area after 8 weeks. In conclusions, The Exendin4-PEGDA/HA mineralized hydrogel can effectively repair bone defects in rats, and it is expected to be used as a biomaterial for human bone tissue repair.

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Section: Discussionmentioning

confidence: 99%

PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

Liu

Jing

et al. 2021

J Biomater Appl

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“…Although the changes in the mechanical properties of cement were not introduced in the article, they were presumably seriously weakened. 168 Improved mechanical properties could be presented by CMCS-modified PMMA; CMCS is a natural polysaccharide with water solubility and is associated with anti-tumor activity, according to research. 196,197 Liu et al 198 incorporated MTX and CMCS into PMMA-fabricated composite cement, providing a DDS with intensive drug release and more persistence than pure PMMA.…”

Section: Modification Of Pmma To Enhance the Anti-tumor Efficiencymentioning

confidence: 99%

Comprehensive evaluation and advanced modification of polymethylmethacrylate cement in bone tumor treatment

Chao,

Jiao,

Yang

et al. 2023

J. Mater. Chem. B

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“…The liquid phase of the cement mixture is composed of urethane dimethacrylate (UDMA, 3%), an organic monomer with a large and rigid structure; hydroxyethyl methacrylate (HEMA, 25%), which acts as a viscosity modifier; and polyethylene glycol (PEG 400, 22%), an ingredient that has low-level toxicity and is very hydrophilic [33]. The organic matrix influences the properties of the cement, such as the amount of unreacted monomer, fluid absorption, and mechanical properties.…”

Section: Sample Preparationmentioning

confidence: 99%

The Influence of Chitosan on Water Absorption and Solubility of Calcium Phosphate Cement

Lacan,

Moldovan,

Ardelean

2023

Coatings

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Calcium phosphate cements are widely used biomaterials for bone regeneration due to their biological properties, such as biocompatibility, biodegradability, and bioactivity. The presence of chitosan in cement composition influences the resorption rate of the material and its mechanical properties. In the present work, the water absorption and solubility of a tricalcium phosphate bone cement, prepared with and without chitosan addition, was comparatively evaluated. The absorption and solubility properties were monitored for 21 days by immersing the samples in water at room temperature and then weighing them. A morphological analysis of the samples was carried out via scanning electron microscopy (SEM). The absorption dynamics and pore evolution were investigated with low-field nuclear magnetic resonance (NMR) relaxometry. It was demonstrated that the presence of chitosan accelerates the hardening dynamics, reduces water absorption, and influences the solubility and degradation behavior of the cement. It was also observed that, independent of the presence of chitosan, the polymerization process is not completed even after one hour, which influences the solubility process. It was also shown that the presence of chitosan reduces the amount of microcracks and improves the functional properties of the hardened cement.

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Polyethylene glycol improves elution properties of polymethyl methacrylate bone cements

Cited by 13 publications

References 23 publications

PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

PEGDA/HA mineralized hydrogel loaded with Exendin4 promotes bone regeneration in rat models with bone defects by inducing osteogenesis

Comprehensive evaluation and advanced modification of polymethylmethacrylate cement in bone tumor treatment

The Influence of Chitosan on Water Absorption and Solubility of Calcium Phosphate Cement

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