Polyethyleneimine and quaternized ammonium polyethyleneimine: the versatile materials for combating bacteria and biofilms

Lan, Tianyu; Guo, Qianqian; Shen, Xiangchun

doi:10.1080/09205063.2019.1627650

Cited by 24 publications

(20 citation statements)

References 43 publications

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“…These can be assigned to methylene (−CH 2 −) protons in the aliphatic branched PEI chains. 41 Further signals at 0.8–1.2 ppm match well with literature values assigned to quaternized polyethylenimine after alkylation with a methyl group. 42 Further information on the quaternization of membranes was gathered via elemental analysis ( Table 3 ).…”

Section: Results and Discussionsupporting

confidence: 86%

Asymmetric Membrane Capacitive Deionization Using Anion-Exchange Membranes Based on Quaternized Polymer Blends

McNair

Cseri

Székely

et al. 2020

ACS Appl. Polym. Mater.

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Membrane capacitive deionization (MCDI) for water desalination is an innovative technique that could help to solve the global water scarcity problem. However, the development of the MCDI field is hindered by the limited choice of ion-exchange membranes. Desalination by MCDI removes the salt (solute) from the water (solvent); this can drastically reduce energy consumption compared to traditional desalination practices such as distillation. Herein, we outline the fabrication and characterization of quaternized anion-exchange membranes (AEMs) based on polymer blends of polyethylenimine (PEI) and polybenzimidazole (PBI) that provides an efficient membrane for MCDI. Flat sheet polymer membranes were prepared by solution casting, heat treatment, and phase inversion, followed by modification to impart anion-exchange character. Scanning electron microscopy (SEM), atomic force microscopy (AFM), nuclear magnetic resonance (NMR), and Fourier-transform infrared (FTIR) spectroscopy were used to characterize the morphology and chemical composition of the membranes. The as-prepared membranes displayed high ion-exchange capacity (IEC), hydrophilicity, permselectivity and low area resistance. Due to the addition of PEI, the high density of quaternary ammonium groups increased the IEC and permselectivity of the membranes, while reducing the area resistance relative to pristine PBI AEMs. Our PEI/PBI membranes were successfully employed in asymmetric MCDI for brackish water desalination and exhibited an increase in both salt adsorption capacity (>3×) and charge efficiency (>2×) relative to membrane-free CDI. The use of quaternized polymer blend membranes could help to achieve greater realization of industrial scale MCDI.

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Section: Results and Discussionsupporting

confidence: 86%

Asymmetric Membrane Capacitive Deionization Using Anion-Exchange Membranes Based on Quaternized Polymer Blends

McNair

Cseri

Székely

et al. 2020

ACS Appl. Polym. Mater.

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“…, charge density and number) of MDPs can promote their binding to the anionic biomembrane surface and thus improve membrane-disruptive activities. To date, many linear peptides/peptidomimetics, such as chitosan (CS) 102 , linear polyethyleneimine (PEI) 103 , α -poly( l -lysine) (PLL) 37 , and ε -poly( l -lysine) (EPL) 104 , 105 have been shown to provide abundant positively charged residues for attaching bacteria. However, increasing studies have demonstrated that diverse molecular architecture, including cyclic, dendritic, brush, and star-shaped structures, may impart a more significant difference in regulating the charging effects, membrane-disruptive activities, and selectivity of MDPs ( Fig.…”

Section: Mdps and Their Mechanisms Of Actionmentioning

confidence: 99%

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Lin

Chi

Yan

et al. 2021

Acta Pharmaceutica Sinica B

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Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or anticarcinogens that present a general killing mechanism through the physical disruption of cell membranes, in contrast to conventional chemotherapeutic drugs, which act on precise targets such as DNA or specific enzymes. Owing to their rapid action, broad-spectrum activity, and mechanisms of action that potentially hinder the development of resistance, MDPs have been increasingly considered as future therapeutics in the drug-resistant era. Recently, growing experimental evidence has demonstrated that MDPs can also be utilized as adjuvants to enhance the therapeutic effects of other agents. In this review, we evaluate the literature around the broad-spectrum antimicrobial properties and anticancer activity of MDPs, and summarize the current development and mechanisms of MDPs alone or in combination with other agents. Notably, this review highlights recent advances in the design of various MDP-based drug delivery systems that can improve the therapeutic effect of MDPs, minimize side effects, and promote the co-delivery of multiple chemotherapeutics, for more efficient antimicrobial and anticancer therapy.

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“…In contrast, the contact-killing strategy relies on a positively charged surface and a permeabilization of the bacterial cell surface that leads to the leakage of intracellular material and eventual cell death. One of the reported approaches involves grafting polyethyleneimine (PEI) [74] micro-brushes onto polyurethane (PU) stents followed by an alkylation process [75,76]. The resulting micro-structure of PEI brushes with positive charges showed a reduction in both biofilm and encrustation in vitro and in vivo [76].…”

Section: Electrical Charges To Prevent Biofilm Adhesionmentioning

confidence: 99%

Potential strategies to prevent encrustations on urinary stents and catheters – thinking outside the box: a European network of multidisciplinary research to improve urinary stents (ENIUS) initiative

Abou‐Hassan

Barros

Buchholz³

et al. 2021

Expert Review of Medical Devices

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Polyethyleneimine and quaternized ammonium polyethyleneimine: the versatile materials for combating bacteria and biofilms

Cited by 24 publications

References 43 publications

Asymmetric Membrane Capacitive Deionization Using Anion-Exchange Membranes Based on Quaternized Polymer Blends

Asymmetric Membrane Capacitive Deionization Using Anion-Exchange Membranes Based on Quaternized Polymer Blends

Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

Potential strategies to prevent encrustations on urinary stents and catheters – thinking outside the box: a European network of multidisciplinary research to improve urinary stents (ENIUS) initiative

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