Polyfunctional Drugs: Search, Development, Use in Medical Practice, and Environmental Aspects of Preparation and Application (A Review)

Belakhov, V. V.

doi:10.1134/s1070363222130047

Cited by 1 publication

(1 citation statement)

References 245 publications

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“…There has been significant activity in this area mainly in dual targeting approaches and some relevant reviews include those on the identification and development of polyfunctional drugs covering mainly antibiotics [26], different types of non-cleavable antibiotic hybrids [11,27], approaches for the realization of what have been called 'resistance-resistant' antibacterial strategies [28], and recently approved antibiotics by the FDA (14 out of a total of 27 that entered the market from the year 2000 to 2020) which are multi-targeting in their actions [29]. In these cases, the drugs are known to interact with more than one biological component in a pathway or with other components in different biochemical pathways in bacteria.…”

Section: Single-molecule Non-cleavable Hybridsmentioning

confidence: 99%

An Update Review of Approaches to Multiple Action-Based Antibacterials

Bremner

2023

Antibiotics

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Many approaches are being pursued to address the major global health challenge posed by the increasing resistance of pathogenic bacteria to antibacterial agents. One of the promising approaches being investigated includes the design and development of multiple action-based small-molecule antibacterials. Aspects of this broad area have been reviewed previously, and recent developments are addressed in this update review covering the literature mainly over the past three years. Considerations encompassing drug combinations, single-molecule hybrids and prodrugs are summarised in regard to the intentional design and development of multiple-action agents with a focus on potential triple or greater activities in bacteria. The hope for such single agents or combinations of single agents is that resistance development will be significantly hindered, and they may be useful in tackling bacterial disease caused by both resistant and non-resistant bacteria.

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Section: Single-molecule Non-cleavable Hybridsmentioning

confidence: 99%

An Update Review of Approaches to Multiple Action-Based Antibacterials

Bremner

2023

Antibiotics

View full text Add to dashboard Cite

show abstract

Polyfunctional Drugs: Search, Development, Use in Medical Practice, and Environmental Aspects of Preparation and Application (A Review)

Cited by 1 publication

References 245 publications

An Update Review of Approaches to Multiple Action-Based Antibacterials

An Update Review of Approaches to Multiple Action-Based Antibacterials

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