Polygenic association of the renin-angiotensinaldosterone system polymorphisms in essential arterial hypertension

Павлова, О.С.; Ogurtsova, S. E.; Горбат, Т. В.; Ливенцева, М М; Афонин, В. Ю.; Малюгин, В. И.; Mrochek, Alexander

doi:10.18705/1607-419x-2016-22-3-253-262

Cited by 6 publications

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“…Тема управления рисками является востребованной в различных сферах медицины [1][2][3], и в данной статье рассмотрим риск-ориентированный подход в стоматологии.…”

Section:  введениеunclassified

“…В представленных работах [1][2][3], поскольку риск -воздействие неопределенности (см. ISO 9000) R=F (U; P), факторы, влияющие на развитие заболевания, воздействуют в вероятностной постановке P, приводят к ущербу U. Необходимо спрогнозировать вероятностное влияние исследуемого фактора на значимость последствий, т. е. ущерб U.…”

Section:  введениеunclassified

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Development of Elements of a Risk Management Methodology and Evaluation of the Effectiveness of the Choice of Material for Fixation of Dentures

Кронивец

2024

Стоматология. Эстетика. Инновации

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Этап фиксации несъемных конструкций зубных протезов является одним из важнейших звеньев ортопедического лечения, а правильный выбор материала для фиксации – наиболее значимым для надежной фиксации несъемных зубных протезов на опорных зубах, поэтому отдаленные результаты могут быть измерены таким показателем, как продолжительность использования несъемного зубного протеза. Типичной причиной нарушения фиксации является недостаточная адгезия к тканям протезного ложа и конструкционным материалам. Необходимо было разработать элементы методологии управления рисками и оценить эффективность ортопедического лечения несъемными конструкциями дефектов твердых тканей зубов и зубных рядов с использованием критериев оценки качества протезирования. Для достижения этого исследовались причины несоответствий, вероятность влияния различных факторов на последствия – надежность фиксации. Предложена классификация и идентификация значимости ущерба последствий для пациентов в целях управления рисками (первый элемент методологии). Исследовалась вероятность влияния значимых факторов на надежность фиксации (второй элемент методологии), а также взаимосвязь и взаимовлияние сложных нелинейных процессов значимых факторов на последствия (третий элемент методологии). По результатам изучения физико-механических свойств фиксирующих материалов для ортопедического лечения пациентов был разработан алгоритм выбора материала для фиксации зубных протезов, который внедрили в клиническую практику. Анализ результатов клинической оценки качества ортопедического лечения несъемными конструкциями при дифференцированном применении материала для фиксации в отдаленные сроки после ортопедического лечения позволил установить, что предложенный алгоритм выбора фиксирующего материала в зависимости от материала протеза и тканей протезного ложа является действенным для снижения риска осложнений и позволяет достичь высокой клинической эффективности: отсутствие нарушения устойчивости протеза наблюдается в 97,2% случаев. The stage of fixation of fixed denture structures is one of the most important parts of orthopedic treatment, and the correct choice of material for fixation is the most significant for reliable fixation of fixed dentures on abutment teeth, therefore long-term results can be measured by such an indicator as the duration of use of a fixed denture. A typical cause of fixation failure is insufficient adhesion to the tissues of the prosthetic bed and to structural materials. It was necessary to develop elements of a risk management methodology and evaluate the effectiveness of orthopedic treatment with fixed structures for defects in the hard tissues of teeth and dentition, using criteria for assessing the quality of prosthetics. To achieve this, the causes of inconsistencies, the likelihood of the influence of various factors on the consequences, and the reliability of fixation were investigated. A classification and identification of the significance of harm consequences for patients for risk management is proposed (the first element of the methodology). The probabilities of the influence of significant factors on the reliability of fixation (the second element of the methodology) were studied. The relationship and mutual influence of complex nonlinear processes of significant factors on the consequences was studied (the third element of the methodology). Based on the results of studying the physical and mechanical properties of fixing materials for orthopedic treatment of patients, an algorithm for selecting a material for fixing dentures was developed, which was introduced into clinical practice. Analysis of the results of clinical assessment of the quality of orthopedic treatment with fixed structures with differentiated use of material for fixation in the long term after orthopedic treatment made it possible to establish that the proposed algorithm for selecting a fixation material depending on the material of the prosthesis and the tissues of the prosthetic bed is effective in reducing the risk of complications and allows achieving high clinical results. effectiveness: no violation of the stability of the prosthesis is observed in 97.2% of cases.

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Section:  введениеunclassified

Development of Elements of a Risk Management Methodology and Evaluation of the Effectiveness of the Choice of Material for Fixation of Dentures

Кронивец

2024

Стоматология. Эстетика. Инновации

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Renin-angiotensin system gene polymorphism and aging

Bebyakova,

Levitsky,

Shabalina

et al. 2024

Ekologiya cheloveka (Human Ecology)

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A personalized healthy aging program based on the preservation of the intrinsic capacity as a set of functional abilities in old age should take into account genetic (hereditary) factors that affect the structure and functions of organs and systems of the body and their age-related changes. An individual genetic profile can be an important tool for ensuring healthy aging. For this reason, numerous studies focus on identifying the genetic mechanisms of aging and longevity and the associated multifactorial diseases. The renin-angiotensin system (RAS) disorders contribute to the formation of pathological conditions associated with cardiovascular disease, cognitive changes, functioning of auditory and visual analyzers, and are the probable predictors of functional disorders in older adults. This article is a literature review of the involvement of RAS gene polymorphisms in the aging processes. The performed analysis of modern domestic and foreign literature has brought new light on the contribution of polymorphic variants of the angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin II receptor type 1 (AGTR1) genes to the occurrence and development of pathological conditions and the associated decreases in the intrinsic capacity. The findings suggest that testing for these polymorphisms can be of a practical importance for personalized prognosis and the development of timely preventive programs aimed at improving life expectancy and quality among the elderly.

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Polygenic analysis of genetic susceptibility to essential hypertension

et al. 2022

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Objective. To investigate the molecular mechanism underlying genetic susceptibility to essential hypertension (EH) using polygenic analysis of renin-angiotensin-aldosterone system (RAAS).Design and methods. Genotyping of renin (REN, rs2368564), angiotensinogen (AGT, rs4762), angiotensin II receptor type 1 (AGTR1, rs5186), chymase 1 (CMA1, rs1800875) and angiotensin-converting enzyme (ACE, rs1799752) polymorphic variants was performed in 346 patients with EH and 377 controls, Russians and Tatars by ethnic origin.Results. ACE rs1799752polymorphism was significantly associated with EH risk in Tatars (PBonf = 0,003) and in the total study group (PBonf = 4,09 x 10–5). Polygenic approach identified 12 genotypes and/or alleles combinations of RAAS genes polymorphisms, significantly associated with EH in the Tatars, and 6 patterns associated with EH in the total study group. The highest risk of disease in Tatar men was associated with REN rs2368564*T + AGTR1 rs5186*C/A + ACE rs1799752*D combination (OR = 16,64, PBonf = 0,001), in the total group — with REN rs2368564*T/C + CMA1 rs1800875*G combination (OR = 2,37, PBonf = 0,045).Conclusions. Our findings indicate that EH risk in men of Russian and Tatar ethnicity is significantly associated with ACE rs1799752 polymorphism, and the results of polygenic analysis demonstrate an association of the disease risk with genotype/allele combinations of polymorphic variants in REN (rs2368564), AGTR1 (rs5186), ACE (rs1799752), and CMA1 (rs1800875) genes.

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Polygenic association of the renin-angiotensinaldosterone system polymorphisms in essential arterial hypertension

Cited by 6 publications

References 0 publications

Development of Elements of a Risk Management Methodology and Evaluation of the Effectiveness of the Choice of Material for Fixation of Dentures

Development of Elements of a Risk Management Methodology and Evaluation of the Effectiveness of the Choice of Material for Fixation of Dentures

Renin-angiotensin system gene polymorphism and aging

Polygenic analysis of genetic susceptibility to essential hypertension

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