Purpose: The national project "Education" defines the vector of the development of the Russian education system for 2019-2024. In order to achieve its goals, tasks and indicators, it is necessary to attract investments and competencies of the private sector on the basis of public-private partnership. Design/Methodology/Approach: In the course of the study, there were used methods of system analysis, methods of scientific analysis, induction and deduction, comparison and grouping as tools of scientific research. Findings: The article proves that the Russian regions need additional investments to create a modern educational infrastructure and its maintenance. This is connected with the predominant financing of current costs from the consolidated budgets of the subjects of the Russian Federation on preschool , general and vocational education, the demographic situation and the differentiated level of socioeconomic development of the regions. Practical Implications: Authors proposed an activity contributing to the development of public-private partnerships in the subjects of the Russian Federation, providing the formation of a modern educational infrastructure. Originality/Value: The study presents the original approach in development of publicprivate partnership in the context of modern legal incentives in Russia.

The article grounds the need for private-public partnership development in the Russian educational system. Authors highlighted the issues of state, educational, and business institutions' interaction considering the best foreign experience. Authors suggest more attention to the funding of innovational infrastructure of universities in the context of public-private partnership providing economic stability and increase in budget revenues as well as in social expenditures.

The article proves that the Russian regions need additional investments to create a modern educational infrastructure and its maintenance. This is due to the predominant financing from the consolidated budgets of the constituent entities of the Russian Federation of current expenditures on preschool , General and vocational education, the demographic situation, the differentiated level of socioeconomic development of the regions. proposed activities are contributing to the revitalization of the development of public-private partnerships in constituent entities of the Russian Federation, providing creation of a modern educational infrastructure.

Objective. To investigate the molecular mechanism underlying genetic susceptibility to essential hypertension (EH) using polygenic analysis of renin-angiotensin-aldosterone system (RAAS).Design and methods. Genotyping of renin (REN, rs2368564), angiotensinogen (AGT, rs4762), angiotensin II receptor type 1 (AGTR1, rs5186), chymase 1 (CMA1, rs1800875) and angiotensin-converting enzyme (ACE, rs1799752) polymorphic variants was performed in 346 patients with EH and 377 controls, Russians and Tatars by ethnic origin.Results. ACE rs1799752polymorphism was significantly associated with EH risk in Tatars (PBonf = 0,003) and in the total study group (PBonf = 4,09 x 10–5). Polygenic approach identified 12 genotypes and/or alleles combinations of RAAS genes polymorphisms, significantly associated with EH in the Tatars, and 6 patterns associated with EH in the total study group. The highest risk of disease in Tatar men was associated with REN rs2368564*T + AGTR1 rs5186*C/A + ACE rs1799752*D combination (OR = 16,64, PBonf = 0,001), in the total group — with REN rs2368564*T/C + CMA1 rs1800875*G combination (OR = 2,37, PBonf = 0,045).Conclusions. Our findings indicate that EH risk in men of Russian and Tatar ethnicity is significantly associated with ACE rs1799752 polymorphism, and the results of polygenic analysis demonstrate an association of the disease risk with genotype/allele combinations of polymorphic variants in REN (rs2368564), AGTR1 (rs5186), ACE (rs1799752), and CMA1 (rs1800875) genes.

No abstract