Polygonatone H, a new homoisoflavanone with cytotoxicity from <i>Polygonatum Cyrtonema</i> Hua.

Wang, Wenxiang; Dabu, Xilatu; He, Juan; Yang, Huixiang; Yang, Shengchao; Chen, Junwen; Fan, Wei; Zhang, Guanghui; Cai, Jin‐Long; Ai, Hong‐Lian; Hai, Mei-Rong

doi:10.1080/14786419.2018.1434645

Cited by 27 publications

(12 citation statements)

References 15 publications

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“…Also 5-OH (δ(H) 12.0) proton showed 3 J C-H correlations with carbon at δ(C) 96.0 (C-6) and 102.5 (C-11) which rule out the possibility of methyl attachment at (C-6) ( Figure 2). Based on this data and comparison with [18] compound 1 was assigned as 5,7dihydroxy-3-(4-methoxybenzyl)-8-methylchroman-4one which is reported for the first time to the best of our knowledge. Absolute configuration of 1 was assigned on basis of circular dichroism (CD).…”

Section: Resultsmentioning

confidence: 82%

Antimicrobial Homoisoflavonoids from the Rhizomes of Polygonatum verticillatum

Sharma

Patial

Singh

et al. 2018

Chemistry & Biodiversity

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Three homoisoflavonoids, including a new compound, 5,7‐dihydroxy‐3‐(4‐methoxybenzyl)‐8‐methyl chroman‐4‐one (1), together with two known compounds, 5,7‐dihydroxy‐3‐(2‐hydroxy‐4‐methoxybenzyl)‐8‐methylchroman‐4‐one (2) and 5,7‐dihydroxy‐3‐(2‐hydroxy‐4‐methoxybenzyl)‐chroman‐4‐one (3), were isolated from the rhizomes of Polygonatum verticillatum (L.) All. (P. verticillatum). Isolated compounds were characterized on the basis of UV, FT‐IR, ESI‐MS, and 1D‐, 2D‐NMR data. Further, different extract fractions and pure compounds from Polygonatum verticillatum were screened for their antimicrobial potential. Among three pure compounds, compound 2 was found most potent with good zone of microbial growth inhibition as compared to the standards.

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Section: Resultsmentioning

confidence: 82%

Antimicrobial Homoisoflavonoids from the Rhizomes of Polygonatum verticillatum

Sharma

Patial

Singh

et al. 2018

Chemistry & Biodiversity

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“…By screening the differential quality markers between different origins of PR, it can be seen that peaks 9, 13, and 17 (VIP>1) play an essential role in grouping different origins of PR. LC/MS technology was used to analyze the retention time of the compound, and the mass‐to‐charge ratio fragment information, and matched with the information reported in the relevant literatures [59–61] . The three chemical marker components (9, 13 and 17) were identified as disporopsin, 5,7‐dihydroxy‐3‐(4′‐hydroxybenzyl)‐6,8‐dimethylchroman‐4‐one, (3R)‐5,7‐dihydroxy‐3‐(4′‐hydroxybenzyl)‐6‐methylchroman‐4‐one or isomer (Table 2, Figure S1–4).…”

Section: Resultsmentioning

confidence: 99%

Discrimination of Polygonati Rhizoma Species: An Investigation Utilizing High‐Performance Liquid Chromatography Fingerprints and Chemometrics

Zhou

Liu

Gao

et al. 2023

Chemistry & Biodiversity

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Polygonati Rhizoma has been a famous traditional Chinese medicine (TCM) for two thousand years. It is increasingly being used not just as a traditional herbal medicine but also as a popular functional food. In this study, qualitative and quantitative analysis of PR from three different origins were initially performed using chemical fingerprint and chemometrics methods. Hierarchical cluster analysis (HCA) and Principal component analysis (PCA) were used to classify 60 PR samples from three different origins. The results revealed that the PR samples fell into three clusters related to the origins. In addition, pairwise comparison of varying PR and obtaining chemical markers between different species through the establishment of partial least squares discriminant analysis. Finally, chemical markers 9,13 and 17 were identified by LC/MS as disporopsin, 5,7dihydroxy-3-(4'-hydroxybenzyl)-6,8-dimethylchroman-4-one and (3R)-5,7-dihydroxy-3-(4'-hydroxybenzyl)-6-methylchroman-4one or isomer, respectively. In conclusion, these methods can be applied to identify and distinguish the quality of PR with other original plants and provide novel ideas for evaluating herbal products used in TCM.

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“…Steroidal saponins are characterized by a skeleton derived from oxidosqualene, consisting of a sugar moiety linked to a steroidal (27 carbon atoms) aglycone [6]. Steroidal saponins have attracted extensive attention owing to their excellent anti-bacterial, anti-inflammatory, and anti-oxidation effect and the potential for alleviating diabetes and other metabolic disorders [5,7,8]. Steroidal saponins have been extensively used in the food, medicine, fodder, and cosmetics industries [9].…”

Section: Introductionmentioning

confidence: 99%

Extraction and identification of steroidal saponins from Polygonatum cyrtonema Hua using natural deep eutectic solvent‐synergistic quartz sand‐assisted extraction method

Liu

Feng

Sui

et al. 2023

J of Separation Science

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In this study, quartz sand with particularly sharp nanoscale edges acted like a nanoscale knife physically cut cells of Polygonatum cyrtonema Hua into nanosized particles and was synergized with natural deep eutectic solvent to extract steroidal saponins of Polygonatum cyrtonema Hua. The natural deep eutectic solvent (choline chloride‐lactic acid)‐synergistic quartz sand‐assisted extraction was optimized using response surface methodology. The steroidal saponins purified with AB‐8 macroporous resin were identified using ultra‐high‐performance liquid chromatography‐triple time of flight mass spectrometry. The results showed that the experimental total saponins content value (36.97 ± 0.12 mg dioscin equivalent/g dry weight) at optimal extraction conditions with a temperature of 68°C, a rotational speed of 20 400 rpm, shear time of 4.3 min, the liquid‐solid ratio of 38 ml/g, was close to the maximum possible theoretical value (36.64 mg dioscin equivalent/g dry weight). A total of 20 steroidal saponins were identified, among which the content of (25R)‐Kingianoside E was the highest (102.66 ± 3.47 mg/g). Furthermore, a new steroid saponin (3β,25S)‐26‐(β‐D‐glucopyranosyloxy)‐22‐hydroxyfurost‐5‐en‐3‐yl 4‐O‐β‐D‐glucopyranosyl‐β‐D‐galactopyranoside+Glc was found for the first time. These results revealed that natural deep eutectic solvent‐synergistic quartz sand‐assisted extraction was an efficient and green method to extract a variety of steroidal saponins.

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Polygonatone H, a new homoisoflavanone with cytotoxicity from Polygonatum Cyrtonema Hua.

Cited by 27 publications

References 15 publications

Antimicrobial Homoisoflavonoids from the Rhizomes of Polygonatum verticillatum

Antimicrobial Homoisoflavonoids from the Rhizomes of Polygonatum verticillatum

Discrimination of Polygonati Rhizoma Species: An Investigation Utilizing High‐Performance Liquid Chromatography Fingerprints and Chemometrics

Extraction and identification of steroidal saponins from Polygonatum cyrtonema Hua using natural deep eutectic solvent‐synergistic quartz sand‐assisted extraction method

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