Polyimide microfluidic devices with integrated nanoporous filtration areas manufactured by micromachining and ion track technology

Metz, Stefan; Trautmann, C.; Bertsch, Arnaud; Renaud, Philippe

doi:10.1088/0960-1317/14/3/002

Cited by 77 publications

(47 citation statements)

References 21 publications

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“…Various microconcentrators working with membrane structures have been reported, such as inorganic microfiltration membranes using laser interference lithography (Kuiper et al 1998), ultrafiltration membrane by micro-stereo lithography (MSL) process (Ikuta et al 1999), polyimide nanoporous filtration membrane using ion-tracking technology and subsequent chemical etching (Metz et al 2004) and microstructured membrane (Irimia and Toner 2006). However, owing to the existence of 'dead-ends' in such membrane-based microfilters or microconcentrators with the penetrating flow in the same direction as the main flow, combined with the deformability and adhesion of the cells, clogging failure is inevitable (Dong et al 2009.…”

Section: Introductionmentioning

confidence: 99%

Integratable non-clogging microconcentrator based on counter-flow principle for continuous enrichment of CaSki cells sample

Dong¹,

Yang²,

Su³

et al. 2010

Microfluid Nanofluid

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This study addresses the need to reduce the risk of clogging when preparing samples for cell concentration, i.e., the CaSki Cell-lines (epidermoid cervical carcinoma cells). Aiming to develop a non-clogging microconcentrator, we proposed a new counter-flow concentration unit characterized by the directions of penetrating flows being at an obtuse angle to the main flow, due to employment of streamlined turbine blade-like micropillars. Based on the optimization results of the counter-flow unit profile, a fractal arrangement for the counter-flow concentration unit was developed. A counter-flow microconcentrator chip was then designed and fabricated, with both the processing layer and collecting layer arranged in terms of the honeycomb structure. Visualized experiments using CaSki cell samples on the microconcentrator chip demonstrated that no cell-clogging phenomena occurred during the test and that no cells were found in the final filtrate. The test results show an excellent concentration performance for the microconcentrator chip, while a concentrating ratio of [4 with the flow rate being below 1.0 ml/min. As only geometrical structure is employed in the passive device, the counter-flow microconcentrator can be easily integrated into advanced microfluidic systems. Owing to the merit of non-clogging and continuous processing ability, the counter-flow microconcentrator is not only suitable for the sample preparation within biomedical field, but also applicable in water-particle separation.

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Section: Introductionmentioning

confidence: 99%

Integratable non-clogging microconcentrator based on counter-flow principle for continuous enrichment of CaSki cells sample

Dong¹,

Yang²,

Su³

et al. 2010

Microfluid Nanofluid

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“…Although used in numerous scientific and technological fields (Spohr, 1980;Metz et al, 2004;Reber et al, 1999;Yoshida et al, 1997), filtration is probably one of the most popular applications. Over the many years, pore fabrication was extended to different polymer materials and the size of the pores became smaller and smaller.…”

Section: Introductionmentioning

confidence: 99%

Cylindrical nanochannels in ion-track polycarbonate membranes studied by small-angle X-ray scattering

et al. 2007

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Different types of polycarbonate foils were irradiated with 1.4 GeV Xe ions, ultra-violet (UV) treated and subsequently etched, creating cylindrical pores of high aspect ratio. The pores are perfectly well aligned and represent excellent objects for small-angle X-ray scattering. Two-dimensional scattering spectra exhibit highly anisotropic patterns with clear presentation of numerous oscillations of the Bessel function, the radial part of the scattering function. Modelling the pores as parallel cylinders allows us to deduce the pore radius and the radius dispersion as a function of UV treatment, etching time and fluence. It is demonstrated that the UV treatment has a beneficial influence on the poresize distribution, in particular for small pores.

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“…Furthermore, these devices had very small filter areas that restrain the flow rates. On-chip filters can also be made by irradiating a designated area with heavy ions to generate sub-micrometer pores (Metz et al 2004). Although compatible with common chip fabrication methods and effective in retaining microbes, this method requires heavy-ion accelerators which are not easily accessible to general researchers.…”

Section: Introductionmentioning

confidence: 99%

Embedding off-the-shelf filter in PDMS chip for microbe sampling

Lécluse

Chao

Meldrum

2011

Microfluid Nanofluid

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Filtration for microfluidic sample-collection devices is desirable for sample selection, concentration, preprocessing, and manipulation, but microfabricating the required sub-micrometer structures is an elaborate process. This article presents a simple method to integrate filters in polydimethylsiloxane (PDMS) devices to sample microorganisms in aqueous environments. An off-the-shelf membrane filter with 0.22-lm pores was embedded in a PDMS layer and sequentially bound with other PDMS channel layers. No leakage was observed during filtration. This device was validated by concentrating a large amount of biomass, from 15 9 10 7 to 3 9 10 8 cells/ml of cyanobacterium Synechocystis in simulated sample water with consistent performance across devices. The major advantages of this method are low cost, simple design, straightforward fabrication, and robust performance, enabling wide-utility of chip-based devices for field-deployable operations in environmental microbiology.

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Polyimide microfluidic devices with integrated nanoporous filtration areas manufactured by micromachining and ion track technology

Cited by 77 publications

References 21 publications

Integratable non-clogging microconcentrator based on counter-flow principle for continuous enrichment of CaSki cells sample

Integratable non-clogging microconcentrator based on counter-flow principle for continuous enrichment of CaSki cells sample

Cylindrical nanochannels in ion-track polycarbonate membranes studied by small-angle X-ray scattering

Embedding off-the-shelf filter in PDMS chip for microbe sampling

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