Polyketide Derivatives from <i>Annona muricata</i> Linn Leaves as Potencial Anticancer Material by Combination Treatment With Doxorubicin on Hela Cell Line

Artanti, Anif Nur; Astirin, Okid Parama; Prayito, A; Widiyaningsih, R F; Prihapsara, Fea

doi:10.1088/1757-899x/176/1/012002

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…The study showed Linn leaves extracts with doxorubicin in reducing the development of Hela cells. In the study, 38.5 µg/mL polyketide derivatives isolated from the plant were shown to have a synergistic effect with every concentration of doxorubicin used during the treatment of Hela cells (79).…”

Section: Liver Cancermentioning

confidence: 99%

Potential Benefits of Annona muricata in Combating Cancer: A Review

Wong

et al. 2018

MJMS

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The incidence of cancer is increasing each year, which generates concerns regarding the efficacy of the current treatment options. This has caused patients to seek alternatives to complement or to replace surgery, chemotherapy and radiotherapy. and other plants have been shown to have promising compounds that can be utilised in the treatment of cancer. Native to the tropical and subtropical parts of the world, plant extracts contain compounds that are particularly effective against cancer cells. In light of increasing concerns regarding the limitations of cancer treatment in hospitals, this review attempts to highlight the benefits of and its potential to be integrated as one of the treatment options against cancer.

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Section: Liver Cancermentioning

confidence: 99%

Potential Benefits of Annona muricata in Combating Cancer: A Review

Wong

et al. 2018

MJMS

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“…The Combinational Index (CI) values were calculated by CompuSyn . The CI values were mostly between 0.7 and 1.1, which was considered to have an additive or middle synergistic effect (Table ).…”

Section: Resultsmentioning

confidence: 99%

Naphtho-γ-pyrone Dimers from an Endozoic Aspergillus niger and the Effects of Coisolated Monomers in Combination with Cisplatin on a Cisplatin-Resistant A549 Cell Line

Liu

Guo

et al. 2021

J. Nat. Prod.

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Chemotherapy resistance is one of the main causes of lung cancer treatment failure, and a combination regimen may be an effective way to overcome this. Here we report 5 new (1–3, 7, and 9) and 15 known polyketides, isolated from an endozoic Aspergillus niger. The structures of the new compounds were determined by the interpretation of IR, HRESIMS, NMR, and ECD spectra. The ESI-MS/MS fragmentation of the isolated naphtho-γ-pyrone isomers in positive mode is discussed. The effects of isolated compounds in combination with cisplatin (DDP) on a DDP-resistant A549 cell line (A459/DDP) are investigated. The most active compound, 12, could reduce the ratio of GSH/GSSG, promote the generation of intracellular ROS, and cooperate with DDP to down-regulated levels of Nrf2, Akt, HO-1, and NQO1, suggesting that inhibition of Nrf2 and Akt pathways might be involved in the combined effect of 12 and DDP in A549/DDP cells.

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“…In contrast, Suyatmi et al [52] stated that the anticancer activity of the ethanol extract of A. muricata leaves against HeLa cells (cervical) had an LC 50 value of 97 ppm. A previous study by Artanti et al [53] showed that the cervical anticancer activity of polyketide derivatives from the leaf extract of A. muricata was 77.09 ppm.…”

Section: Discussionmentioning

confidence: 95%

Cervical anticancer activities of Annona squamosa Linn. leaf isolate

Swantara

Rita

Dira³

et al. 2022

Vet World

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Background and Aim: Cancer is one of the leading causes of death, the need for new anticancer herbal drugs is becoming more urgent considering the side effects of synthetic drugs. This study aimed to determine the anticancer activity of isolates derived from the methanol extract of Annona squamosa Linn. leaves and to identify the compounds that have an active effect against HeLa cells. Materials and Methods: The leaf metabolites of A. squamosa L. were extracted using methanol at room temperature (28°C) and were partitioned into n-hexane, chloroform, and n-butanol. The toxicity test of these extracts was conducted using a brine shrimp lethality assay. Furthermore, the most toxic extracts were separated and purified using silica gel column chromatography to yield four isolate fractions: FA, FB, FC, and FD. The most toxic isolates were tested for anticancer against HeLa cells, and their compounds were identified using liquid chromatography-mass spectrometry. Results: The results showed that the most toxic isolate with an LC50 value of 100.00 ppm had a potency similar to that of an anticancer agent with an IC50 value of 70.9021 ppm. Furthermore, the five compounds identified in this isolate include (6S, 7aR)-6-hydroxy-4,4,7a-trimethyl-6,7-dihydro-5H-1-benzofuran-2-one or loliolide, cocamidopropyl betaine, N-[3- (dimethylamino)propyl]dodecanamide or lauramidopropyl dimethylamine, linolenic acid, and 1-dodecyl-2-azepanone or laurocapram. Conclusion: It can be concluded that the leaf isolates of A. squamosa Linn. had shown anticancer activities against cervical cancer.

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Polyketide Derivatives from Annona muricata Linn Leaves as Potencial Anticancer Material by Combination Treatment With Doxorubicin on Hela Cell Line

Cited by 3 publications

References 11 publications

Potential Benefits of Annona muricata in Combating Cancer: A Review

Potential Benefits of Annona muricata in Combating Cancer: A Review

Naphtho-γ-pyrone Dimers from an Endozoic Aspergillus niger and the Effects of Coisolated Monomers in Combination with Cisplatin on a Cisplatin-Resistant A549 Cell Line

Cervical anticancer activities of Annona squamosa Linn. leaf isolate

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