Polyketide pesticides from actinomycetes

Li, Shanshan; Yang, Bowen; Tan, Gao-Yi; Ouyang, Liming; Qiu, Shiwen; Wang, Weishan; Xiang, Wensheng; Zhang, Lixin

doi:10.1016/j.copbio.2021.05.006

Cited by 35 publications

(24 citation statements)

References 54 publications

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“…insecticides produced by actinomycetes, including avermectins, spinosyns, polynactins, tetramycins, and analogs (175). Avermectins are found in the fermentation products of Streptomyces avermitilis and are widely commercialized for crop protection.…”

Section: Biocontrol Promoting Actinomycetes As Biopesticidesmentioning

confidence: 99%

“…Their molecular structure has a high ability of binding to muscular neurons of some insects, acting as agonists for γ-aminobutyric acid (GABA)-gated chloride channels, causing insect paralysis and death (176). They are active against several species from the orders Blattodea, Coleoptera, Diptera, Hymenoptera, Isoptera, Lepidoptera, and more (175). Abamectins and emamectins are insecticides derived from avermectins (176).…”

Section: Biocontrol Promoting Actinomycetes As Biopesticidesmentioning

confidence: 99%

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The Potential Use of Actinomycetes as Microbial Inoculants and Biopesticides in Agriculture

et al. 2022

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The use of fertilizers and chemical pesticides promotes significant improvements in crop development, but some problems and risks associated with them limit their application. An alternative is using biological inputs based on microorganisms, increasing production while combining efficiency and sustainability. Actinomycetes are a group of bacteria belonging to the phylum Actinobacteria, recently re-named Actinobacteriota. They represent important microbial communities in the soils with increasing agricultural applications, especially in the biological control of insect-pest and plant disease and in plant growth promotion. Studies report their promising use as microbiological inoculants by exploring mechanisms to improve plant development, such as biological nitrogen fixation, phosphate solubilization, production of phytohormones, and other biocompounds. In addition, many species produce metabolic pathways that generate high-value antibiotics, extracellular enzymes and secondary metabolites other than antimicrobials, with potential in the control of phytopathogenic fungi, insects, and nematodes. These actinomycetes could be used to formulate novel bioinoculants composed of spores and/or mycelium. Considering that the research in this field is up-and-coming, with significant economic and environmental impacts in the future, this review aims to group the most relevant works that explore the biodiversity of actinomycetes, helping to develop inoculants and biodefensives for more productive and conscious agriculture.

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Section: Biocontrol Promoting Actinomycetes As Biopesticidesmentioning

confidence: 99%

Section: Biocontrol Promoting Actinomycetes As Biopesticidesmentioning

confidence: 99%

The Potential Use of Actinomycetes as Microbial Inoculants and Biopesticides in Agriculture

et al. 2022

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“…This is further supported by the detection of insect juvenile hormone antagonists in actinobacteria that inhibit metamorphosis and development in insects (Kim et al, 2020). Successful application of biopesticides, such as avermectins, spinosyns, polynactins and tetramycin from actinobacteria, has been successfully applied in different crops (Li et al, 2021).…”

Section: Actinobacteria‐derived Agro Active Metabolites and Their Che...mentioning

confidence: 99%

Potentiality of actinobacteria to combat against biotic and abiotic stresses in tea [Camellia sinensis (L) O. Kuntze]

Borah

Hazarika

Thakur

2022

Journal of Applied Microbiology

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Tea (Camellia sinensis (L) O. Kuntze) is a long-duration monoculture crop prone to several biotic (fungal diseases and insect pest) and abiotic (nutrient deficiency, drought and salinity) stress that eventually result in extensive annual crop loss. The specific climatic conditions and the perennial nature of the tea crop favour growth limiting abiotic factors, numerous plant pathogenic fungi (PPF) and insect pests. The review focuses on the susceptibility of tea crops to PPF/pests, drought, salinity and nutrient constraints and the potential role of beneficial actinobacteria in promoting tea crop health. The review also focuses on some of the major PPF associated with tea, such as Exobasidium vexans, Pestalotiopsis theae, Colletotrichum acutatum, and pests (Helopeltis theivora). The phylum actinobacteria own a remarkable place in agriculture due to the biosynthesis of bioactive metabolites that assist plant growth by direct nutrient assimilation, phytohormone production, and by indirect aid in plant defence against PPF and pests. The chemical diversity and bioactive significance of actinobacterial metabolites (antibiotics, siderophore, volatile organic compounds, phytohormones) are valuable in the agro-economy. This review explores the recent history of investigations in the role of actinobacteria and its secondary metabolites as a biocontrol agent and proposes a commercial application in tea cultivation.

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“…Initially, using traditional random mutagenesis strategies such as treatment with N-methyl-N′-nitro-N-nitrosoguanidine (NTG) [ 13 ], ultraviolet mutagenesis and atmospheric and room temperature plasma (ARTP) mutation [ 13 , 14 ], a significant increase of milbemycin titer was achieved and strain productivities reached the level for industrial production [ 13 , 14 ]. However, the titer of milbemycins is still much lower than that of another well-exploited polyketide pesticide, avermectin B1a (9 g/L), and it is necessary to fully explore the milbemycin-producing potential of S. bingchenggensis [ [15] , [16] , [17] ]. In recent years, with the developments of genome sequencing, omics, gene editing and synthetic biology technologies, many efforts have been made to understand the biosynthetic pathway and the transcriptional regulation of milbemycins [ 11 , 14 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome-guided identification of a four-component system, SbrH1-R, that modulates milbemycin biosynthesis by influencing gene cluster expression, precursor supply, and antibiotic efflux

Zhang

Shan-shan

et al. 2022

Synthetic and Systems Biotechnology

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Polyketide pesticides from actinomycetes

Cited by 35 publications

References 54 publications

The Potential Use of Actinomycetes as Microbial Inoculants and Biopesticides in Agriculture

The Potential Use of Actinomycetes as Microbial Inoculants and Biopesticides in Agriculture

Potentiality of actinobacteria to combat against biotic and abiotic stresses in tea [Camellia sinensis (L) O. Kuntze]

Transcriptome-guided identification of a four-component system, SbrH1-R, that modulates milbemycin biosynthesis by influencing gene cluster expression, precursor supply, and antibiotic efflux

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