Polyketides from a Marine-Derived Fungus Xylariaceae sp.

Abstract

Eighteen polyketides (1–18) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6, 7, and 17 showed enzyme-inhibitory activities towards several tested enzymes, and 6 and 7 showed strong antifouling activity against Bugula neritina larvae settlement. This is the first time that the antifouling and enzyme-inhibitory activities of these compounds has been reported.

Diversity and function of the Antarctic krill microorganisms from Euphausia superba

“…citrinum OUCMDZ4136 in the SWS medium containing 0.5% NaF. By comparison of NMR and specific rotation data with those reported, their structures were identified as 2,4-dihydroxy-3,5,6-trimethylbenzoic acid ( 1 )1314, citreorosein ( 2 )1516, pinselin ( 3 )17, citrinin ( 4 )181920, dihydrocitrinone ( 5 )2122, pennicitrinone A ( 6 )2324 and quinolactacin A1 ( 7 )25, respectively (Fig. 9).…”

Neuroprotective metabolites from the endophytic fungus Penicillium citrinum of the mangrove Bruguiera gymnorrhiza

“…The relative configuration of 2 was assigned on the basis of the NOESY correlations of H-1 and H-4 with H-11 as well as H-3 with H-12. The absolute configuration of 2 was determined by comparison of its specific optical rotation value ( (Nong et al, 2013), which suggested that the absolute configuration of 2 was also 1S,3R,4S. So, the structure of 2 was elucidated as (1S,3R,4S)-1-(4 0 -hydroxylphenyl)-3,4-dihydro-3,4,5-trimethyl-1H-2-benzopyran-6,8-diol.…”

Review on Molecular Mechanisms of Antifouling Compounds: An Update since 2012

“…Nong et al isolated two natural antifouling products (dicitrinin A and phenol A acid) from the marine gorgonian-derived fungal strain Xylariaceae sp. SCSGAF0086 [ 41 ]. Dicitrinin A shows enzymatic inhibition of Src homology 2 domain-containing phosphotyrosine phosphatase and inosine monophosphate dehydrogenase, while phenol A acid inhibits cathepsin B.…”

“…Dicitrinin A shows enzymatic inhibition of Src homology 2 domain-containing phosphotyrosine phosphatase and inosine monophosphate dehydrogenase, while phenol A acid inhibits cathepsin B. However, the existence of a link between enzyme inhibition and settlement-deterrence of the bryozoan Bugula neritina was not clarified for dicitrinin A and phenol A acid [ 41 ].…”