Polymer-based microneedle composites for enhanced non-transdermal drug delivery

Mbituyimana, Bricard; Ma, Guangrui; Shi, Zhijun; Yang, Guang

doi:10.1016/j.apmt.2022.101659

Cited by 11 publications

(7 citation statements)

References 192 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The microscopic thickness of the outer and inner vessel membranes results in low bioavailability of traditional intravascular drug delivery methods such as balloons and stents [ 51 ]. The high rate of restenosis and neointima formation has prompted investigators to diligently pursue new peritascular or intravascular delivery methods, and MNs offer a potential alternative [ 35 , 192 ]. Unlike traditional MNs used for other tissue repair, MNs used for vascular repair usually require special structural design, combined with flexible substrates or balloons, to ensure that MNs can penetrate the vascular wall without penetrating [ 193 , 194 ].…”

Section: Mns For Istrmentioning

confidence: 99%

“…And MNs can also extract tissue interstitial fluid to obtain disease-related biomarkers [ [29] , [30] , [31] ]. As a result, MNs have been widely used to treat and detect various diseases, including skin cancer, infections, diabetes, obesity, and ocular diseases [ [32] , [33] , [34] , [35] , [36] , [37] , [38] ]. In the field of regenerative medicine, there are two main application pathways of MNs.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microneedles for in situ tissue regeneration

Long¹,

Ji²,

Hu³

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

Section: Mns For Istrmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microneedles for in situ tissue regeneration

Long¹,

Ji²,

Hu³

et al. 2023

Materials Today Bio

View full text Add to dashboard Cite

“…Swellable hydrogel INS-MNs can yield constant and reproducible INS release from the system ( Figure 1 (D)). The biodegradable water-insoluble polymer could be physically (freeze-thawing) or supra molecularly cross-linked (Ye et al., 2023 ) to dry hydrogel and is used for fabricating hydrogel MNs (Mbituyimana et al., 2022 ). After administration into the dermal layer, the hydrogel imbibes the interstitial fluid, expands and produces conduits for INS release through the swollen hydrogel networks.…”

Section: Design Principles For Biodegradable/dissolvable Polymeric In...mentioning

confidence: 99%

“…Dissolving MNs are used for providing bolus INS shots for immediate release. Hydrogel MNs made from cross-linked polymers are used for maintaining steady-state plasma levels of INS for a prolonged duration (Mbituyimana et al., 2022 ). Hydrogel MNs are capable of wicking interstitial fluid to swell and biodegrade slowly in the body thereby releasing the entrapped INS from the cross-linked network.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable polymeric insulin microneedles – a design and materials perspective review

Starlin Chellathurai,

Mahmood,

Mohamed Sofian

et al. 2023

Drug Delivery

View full text Add to dashboard Cite

Microneedle (MN) delivery devices are more accepted by people than regular traditional needle injections (e.g. vaccination) due to their simplicity and adaptability. Thus, patients of chronic diseases like diabetes look for alternative pain-free treatment regimens circumventing regular subcutaneous injections. Insulin microneedles (INS-MNs) are a thoughtfully researched topic (1) to overcome needle phobia in patients, (2) for controlled delivery of the peptide, (3) decreasing the frequency of drug administration, (4) to ease the drug administration procedure, and (5) thus increasing patient adherence to the treatment dosage regimes. MNs physically disrupt the hard outer skin layer to create minuscule pores for insulin (INS) to pass through the dermal capillaries into the systemic circulation. Biodegradable polymeric MNs are of greater significance for INS and vaccine delivery than silicon, metal, glass, or non-biodegradable polymeric MNs due to their ease of fabrication, mass production, cost-effectiveness, and bioerodability. In recent years, INS-MNs have been researched to deliver INS through the transdermal implants, buccal mucosa, stomach wall, intestinal mucosal layers, and colonic mucosa apart from the usual transdermal delivery. This review focuses on the design characteristics and the applications of biodegradable/dissolvable polymeric INS-MNs in transdermal, intra-oral, gastrointestinal (GI), and implantable delivery. The prospective approaches to formulate safe, controlled-release INS-MNs were highlighted. Biodegradable/dissolvable polymers, their significance, their impact on MN morphology, and INS release characteristics were outlined. The developments in biodegradable polymeric INS-MN technology were briefly discussed. Bio-erodible polymer selection, MN fabrication and evaluation factors, and other design aspects were elaborated.

show abstract

“…Various biocompatible and biodegradable polymers have also been used to prepare MNs, such as hydrophobic poly (methyl methacrylate) (PMMA), Polyvinyl alcohol (PVA), Polyvinylpyrrolidone (PVP), polycaprolactone (PCL) and hydrophilic hyaluronic acid (HA), Carboxymethyl Cellulose (CMC), Polyethylene glycol (PEG) et al [ 58 ]. Polymers are not as rigid as silicon and metals, and they are commonly used to make dissolving and hydrogel MNs [ 59 ].…”

Section: Development and Selection Of Mnsmentioning

confidence: 99%

Microneedles: An Emerging Vaccine Delivery Tool and a Prospective Solution to the Challenges of SARS-CoV-2 Mass Vaccination

Feng

Wong

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Vaccination is an effective measure to prevent infectious diseases. Protective immunity is induced when the immune system is exposed to a vaccine formulation with appropriate immunogenicity. However, traditional injection vaccination is always accompanied by fear and severe pain. As an emerging vaccine delivery tool, microneedles overcome the problems associated with routine needle vaccination, which can effectively deliver vaccines rich in antigen-presenting cells (APCs) to the epidermis and dermis painlessly, inducing a strong immune response. In addition, microneedles have the advantages of avoiding cold chain storage and have the flexibility of self-operation, which can solve the logistics and delivery obstacles of vaccines, covering the vaccination of the special population more easily and conveniently. Examples include people in rural areas with restricted vaccine storage facilities and medical professionals, elderly and disabled people with limited mobility, infants and young children afraid of pain. Currently, in the late stage of fighting against COVID-19, the main task is to increase the coverage of vaccines, especially for special populations. To address this challenge, microneedle-based vaccines have great potential to increase global vaccination rates and save many lives. This review describes the current progress of microneedles as a vaccine delivery system and its prospects in achieving mass vaccination against SARS-CoV-2.

show abstract

Polymer-based microneedle composites for enhanced non-transdermal drug delivery

Cited by 11 publications

References 192 publications

Microneedles for in situ tissue regeneration

Microneedles for in situ tissue regeneration

Biodegradable polymeric insulin microneedles – a design and materials perspective review

Microneedles: An Emerging Vaccine Delivery Tool and a Prospective Solution to the Challenges of SARS-CoV-2 Mass Vaccination

Contact Info

Product

Resources

About