Polymer-Based Nanomaterials for Photothermal Therapy: From Light-Responsive to Multifunctional Nanoplatforms for Synergistically Combined Technologies

Pierini, Filippo; Nakielski, Paweł; Urbanek, Olga; Pawłowska, Sylwia; Lanzi, Massimiliano; Sio, Luciano De; Kowalewski, T. A.

doi:10.1021/acs.biomac.8b01138

Cited by 90 publications

(61 citation statements)

References 137 publications

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“…Organic theranostic agents tend to exhibit greater biocompatibility than inorganic agents, which are typically nonbiodegradable and may cause long‐term toxicity . Recently, several pH‐responsive agents based on the pH sensitive NIR dyes have been developed as acid activated photoacoustic imaging and photothermal therapy agents for cancer .…”

Section: Introductionmentioning

confidence: 99%

Tumor pH‐Responsive Albumin/Polyaniline Assemblies for Amplified Photoacoustic Imaging and Augmented Photothermal Therapy

Tian

Jiang

et al. 2019

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Tumor‐microenvironment‐responsive theranostics have great potential for precision diagnosis and effective treatment of cancer. Polyaniline (PANI) is the first reported pH‐responsive organic photothermal agent and is widely used as a theranostic agent. However, tumor pH‐responsive PANI‐based theranostic agents are not explored, mainly because the conversion from the emeraldine base (EB) to emeraldine salt (ES) state of PANI requires pH < 4, which is lower than tumor acidic microenvironment. Herein, a tumor pH‐responsive PANI‐based theranostic agent is designed and prepared for amplified photoacoustic imaging guided augmented photothermal therapy (PTT), through intermolecular acid–base reactions between carboxyl groups of bovine serum albumin (BSA) and imine moieties of PANI. The albumin/PANI assemblies (BSA–PANI) can convert from the EB to ES state at pH < 7, accompanied by the absorbance redshift from visible to near‐infrared region. Both in vitro and in vivo results demonstrate that tumor acidic microenvironment can trigger both the photoacoustic imaging (PAI) signal amplification and the PTT efficacy enhancement of BSA–PANI assemblies. This work not only highlights that BSA–PANI assemblies overcome the limitation of low‐pH protonation, but also provides a facile assembly strategy for a tumor pH‐responsive PANI‐based nanoplatform for cancer theranostics.

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Section: Introductionmentioning

confidence: 99%

Tumor pH‐Responsive Albumin/Polyaniline Assemblies for Amplified Photoacoustic Imaging and Augmented Photothermal Therapy

Tian

Jiang

et al. 2019

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“…However, direct action is highly undesirable because it is unable to discriminate between cancerous and healthy cells. Thus, in order to provide a localized effect in tumors, a sensitizer is delivered to minimize nonspecific absorption . With this aim, drug delivery approaches which employ tumor directing techniques have been exploited .…”

Section: Drug Deliverymentioning

confidence: 99%

The Role of Photochemical Reactions in the Development of Advanced Soft Materials for Biomedical Applications

Fernandez‐Villamarin

Brooks

Mendes

2019

Advanced Optical Materials

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In the biomedical field, many innovative materials to improve diagnosis and treatment of diseases are currently being developed. The ability to respond to different stimuli is one of the more interesting properties of such materials. Light, as one of the nature's elementary stimuli, offers an attractive and flexible stimulus for controlling the properties and functions of biomedical‐related materials. As such, photoresponsive systems have been increasingly pursued and finding applications in various biomedical settings, ranging from tissue engineering for the fabrication of bespoke tissue scaffolds to drug delivery, aims at manipulating treatment distribution inside the human body. Efforts have also been devoted to the development of highly efficient methods to control biological activity and bring us closer to mimicking impressive biological actuators. In this progress report, an overview of recent developments in the field is provided and current challenges discussed. Key strategies tailored to address specific issues are examined, offering useful perspectives for future designs.

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“…The therapeutic efficiency of PTT usually depends on the photothermal agents (PTAs) that can convert light energy into thermal energy for cancer cell killing. Numerous PTAs have been developed, including metal-based PTAs [14][15][16][17][18], carbonbased PTAs [19][20][21][22], melanin-like NPs [23,24], conjugated polymers [25][26][27], black phosphorus [28,29], metal-organic frameworks [30], covalent organic frameworks [31], cyanine-based PTAs [32], and so on. However, some of these PTAs have shortcomings like tedious synthesis, non-degradable property, high cytotoxicity, and low photothermal conversion efficiency.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrion- and nucleus-acting polymeric nanoagents for chemo-photothermal combination therapy

et al. 2020

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Developing intrinsically mitochondria-targetable nanosystems for subcellular structure-oriented precise cancer therapy is highly desirable. Here, we conjugate the cluster determinant 44 (CD44)-targetable hyaluronic acid (HA) with cholesterol-poly(ethylene glycol) 2k -NH 2 and mitochondria-acting IR825-NH 2 (a cyanine dye) to construct a self-assembled nanostructure (abbreviated as HA-IR825-Chol) for photothermal therapy. The HA-IR825-Chol exhibits improved photostability and desirable photothermal properties, and can rapidly and substantially enter CD44-overexpressed cancer cells and selectively accumulate in the mitochondria of the cells. Upon near-infrared laser irradiation, it can induce severe mitochondrial damage, which causes cytochrome c release and triggers cell apoptosis. Furthermore, we demonstrate the feasibility of loading the chemotherapeutics 10-hydroxycamptothecin (HCPT) into the hydrophobic cores of HA-IR825-Chol NPs for combined chemophotothermal therapy. HCPT encapsulated within HA-IR825-Chol achieves significantly increased cellular uptake and simultaneous mitochondrial and nuclear localization, leading to the release of cytochrome c from mitochondria and upregulation of cleaved caspase-3, both of which contribute to the cell apoptosis/death. In vivo experiments reveal the excellent tumor-targeting ability of HA-IR825-Chol/HCPT, ensuring the efficient tumor eradication by the chemo-photothermal therapy. This work exemplifies the development of an intrinsically mitochondria-targetable nanocarrier for precise subcellular structure-localized drug delivery, and the Chol-mediated rapid and massive endocytosis of the nanoagents may represent a robust strategy for enhancing the efficacies of nanomedicines.

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Polymer-Based Nanomaterials for Photothermal Therapy: From Light-Responsive to Multifunctional Nanoplatforms for Synergistically Combined Technologies

Cited by 90 publications

References 137 publications

Tumor pH‐Responsive Albumin/Polyaniline Assemblies for Amplified Photoacoustic Imaging and Augmented Photothermal Therapy

Tumor pH‐Responsive Albumin/Polyaniline Assemblies for Amplified Photoacoustic Imaging and Augmented Photothermal Therapy

The Role of Photochemical Reactions in the Development of Advanced Soft Materials for Biomedical Applications

Mitochondrion- and nucleus-acting polymeric nanoagents for chemo-photothermal combination therapy

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