2010
DOI: 10.1021/ja107333g
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Polymer-Caged Nanobins for Synergistic Cisplatin−Doxorubicin Combination Chemotherapy

Abstract: Multicomponent chemotherapy has increasingly become a strategy of great importance in clinical cancer treatments. However, this type of chemotherapy has not been demonstrated in nanoscale delivery vehicles where two cytotoxic agents can be packaged together, potentially leading to synergistic drug activities. Herein, we present the co-delivery of doxorubicin and cisplatin via a single polymer-caged nanobin (PCN) and show that co-packaging can yield strong synergy in the efficacy of these agents. Such a PCN com… Show more

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Cited by 195 publications
(156 citation statements)
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“…It has been reported that the dose ratio affects the combination effect, 37 and synergistic effects can be induced in certain cases of combinatorial drug delivery. 38,39 To investigate the combination effect of the codelivery system, A549 cells were treated with PMAGP-GEM/PTX NAG-NLCs (different formulations) and free drugs (different formulations).…”
Section: In Vitro Cytotoxicity Analysis Of Different Formulationsmentioning
confidence: 99%
“…It has been reported that the dose ratio affects the combination effect, 37 and synergistic effects can be induced in certain cases of combinatorial drug delivery. 38,39 To investigate the combination effect of the codelivery system, A549 cells were treated with PMAGP-GEM/PTX NAG-NLCs (different formulations) and free drugs (different formulations).…”
Section: In Vitro Cytotoxicity Analysis Of Different Formulationsmentioning
confidence: 99%
“…Thus, the combination of DOX and cisplatin could show a highly synergistic potency, and suppress the growth of tumor cells more efficiently than a single drug. [41][42][43] In this study, chemotherapeutic drug was utilized as a cross-linker to construct a novel dual-drug co-delivery system for the combined delivery of DOX and Pt(IV). The amphiphilic diblock copolymer PCL-b-P(OEGMA-co-AzPMA) was synthesized, and then DOX was encapsulated in the hydrophobic core of the micelles.…”
Section: Introductionmentioning
confidence: 99%
“…On the other side, more and more evidences indicate that cancers cannot be cured with a single drug therapy because of their multiple dysregulated and continuously evolving nature [12]. Inspired by superior therapeutic efficacy from sequential combinatorial chemotherapy routinely used in cancer treatment, treating cancer by the co-delivery of two or more anti-cancer drugs in a single nanovehicle is considered as a promising and reliable strategy due to their synergistic anticancer effect [13,14]. Unfortunately, nanoparticles-mediated combination chemotherapy cannot achieve satisfactory results due to multi-drug resistance (MDR) in cancer cells [15].…”
Section: Introductionmentioning
confidence: 99%