Polymer-coated adsorbents for the separation of biopolymers and particles

Part II. Chromatography using ultra-stable metal oxide-based stationary phases for HPLC

“…Polymer-coated stationary phases that combine the mechanical properties of porous metal oxides, such as silica, alumina, zirconia and titania, with the versatility of organic polymers has been the major focus of this search [73][74][75][76]. Such composite materials show great potential, as ideal chromatographic supports that are mechanically and chemically stable, possess minimal non-specific adsorptivity and allow the flexible tailoring of chromatographic selectivity.…”

New Composite Materials Modified with Nano-Layers of Functionalized Polymers for Bioanalysis and Medical Diagnostics

“…In addition, the surface of the synthesized adsorbents is poorly wetted by both polar and nonpolar liquids, i.e., become fully non-wettable. The bioseparation behaviour of thus obtained PTFE-modified CPG is illustrated by a typical chromatogram of a mixture containing the E. coli plasmid pBR 322, RNA, and associated proteins (Ivanov et al, 1992). It is seen that DNA elutes from the column with the first fraction in the excluded volume, while RNA is weakly retained but likewise elutes in the isocratic regime.…”

“…fluoroolefin ozonides). The polymerization of TFE on the surface of inorganic materials has been described in the literature (Ivanov, Saburov & Zubov 1992). As shown by preliminary experiments, during vapour-or liquid-phase monomer feeding, the grafted polymer does not form a continuous layer and occurs as single globular entities on the surface of an inorganic support.…”

Polyaniline film formation in hexadecyl trimethyl ammonium bromide admicelles on hydrous zirconia surface

“…Materials made by this process may be useful as reinforcing fillers [17], as pigments, and as chromatographic packing materials [18,19]. The technique also provides a way to tailor ordered thin films of conducting polymers on a variety of substrates, which can be useful in fabrication of molecular electronic devices such as electro-optics and microelectronics [20].…”