Polymer complex from copolymers of acrylonitrile and ionic vinyl benzyl compounds

Senuma, Masao; Kuwabara, Shigeru; Kaeriyama, Kyoji; Hase, Fumio; Shimura, Yukio

doi:10.1002/app.1986.070310615

Cited by 13 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polyelectrolyte complexes have gained much attention in the past few years because of their potential applications. These can be used as membranes,[ 1 2 3 ] for coating on films and fibers,[ 4 ] for isolation and fractionation of proteins,[ 5 6 ] for isolation of nucleic acid,[ 7 8 9 ] for binding pharmaceutical products,[ 10 ] as supports for catalyst[ 11 ] and for preparation of microcapsules for drug delivery. [ 12 13 ] Many of the applications are based on the functional properties of the polyelectrolyte (PE).…”

Section: Introductionmentioning

confidence: 99%

In vitro-in vivo evaluation of xanthan gum and eudragit inter polyelectrolyte complex based sustained release tablets

Deb

Bommireddy

Moin

et al. 2015

Int J Pharma Investig

View full text Add to dashboard Cite

Introduction:Polyelectrolyte complexes (PECs) are the association complexes formed between oppositely charged particles (e.g., polymer-polymer, polymer-drug and polymer-drug-polymer). These are formed due to electrostatic interaction between oppositely charged polyions. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) advocated in use of painful and inflammatory rheumatic and certain non-rheumatic conditions. The drug has a relatively short elimination half-life, which limits the potential for drug accumulation. As an analgesic, it has a fast onset and long duration of action.Aim:invitro-invivo evaluation of Xanthan gum and Eudragit E100 inter polyelectrolyte complex based sustained release tablet.Materials and Method:Xanthan gum and Eudragit E100 were used as PEC and were prepared using different proportions i.e. in 1:1 to 1:6 ratio. The optimum ratio of E100 and XG was 1:6 used to characterize the IPC and the formulation of tablet. The tablets were prepared by wet granulation using PVP K30 as binder.Results and Discussion:FT-IR and DSC studies confirmed the formation of IPC. Scanning Electron Microscopy (SEM) studies showed highly porous tablet surface. The tablets were evaluated for hardness, weight variation, and drug content, found to be within limits. In vitro and in vivo studies concluded that tablets showed sustained release profile. The short term stability study of the optimized formulation indicated that the formulation was stable.Conclusion:Since the Poly Electrolyte Complex delay the release of the drug, it can be employed in formulating sustained release matrix tablets.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro-in vivo evaluation of xanthan gum and eudragit inter polyelectrolyte complex based sustained release tablets

Deb

Bommireddy

Moin

et al. 2015

Int J Pharma Investig

View full text Add to dashboard Cite

show abstract

“…One of the most intriguing challenges of this type of system is the interaction between cationic and anionic macromolecules in aqueous solutions, leading to the formation of polyelectrolyte complexes. [9][10][11][12][13][14][15][16][17][18][19] Although investigations of polyelectrolyte complexes have a quite lengthy history, there have been relatively few attempts to examine and interpret the changes in the structural and dynamical properties of mixtures of oppositely charged polyelectrolytes.…”

Section: Introductionmentioning

confidence: 99%

“…The association between surfactants and polyelectrolytes of opposite charge is primarily electrostatic in nature and is reminiscent 2 of the phase separation behavior in mixtures of two oppositely charged polymers. One of the most intriguing challenges of this type of system is the interaction between cationic and anionic macromolecules in aqueous solutions, leading to the formation of polyelectrolyte complexes. − Although investigations of polyelectrolyte complexes have a quite lengthy history, there have been relatively few attempts to examine and interpret the changes in the structural and dynamical properties of mixtures of oppositely charged polyelectrolytes.…”

Section: Introductionmentioning

confidence: 99%

Light Scattering and Viscoelasticity in Aqueous Mixtures of Oppositely Charged and Hydrophobically Modified Polyelectrolytes

et al. 1999

View full text Add to dashboard Cite

Rheological and intensity (ILS) and dynamic light scattering (DLS) experiments were performed on semidilute aqueous mixtures of various compositions of oppositely charged and hydrophobically modified polyelectrolytes. The associative phase separation usually observed when mixing oppositely charged polyelectrolytes is restricted to a fairly narrow mixing region when the polymers are hydrophobically modified. Measurements were carried out at mixing ratios both before and after this two-phase area. The rheological properties in the vicinity of the two-phase region show that the elastic response dominates even at fairly low frequencies, indicating the existence of strong intermolecular interactions. The time correlation data obtained from the DLS experiments revealed the existence of two relaxation modes, one single exponential at short times followed by a stretched exponential at longer times. The fast mode is always diffusive, and the extracted hydrodynamic correlation length as well as the static one from ILS increases toward phase separation of the mixture. The slow relaxation time reveals that the dynamics slowed down in the vicinity of phase separation, and the angular dependence of the slow mode is stronger than that of the fast mode and increases gradually as the two-phase region is approached. These features that are attributed to enhanced hydrophobic associations can be rationalized in the framework of the coupling model of Ngai. The fractal dimension, determined from ILS, drops toward phase separation, and this trend suggests a more “open” network structure at this stage.

show abstract

“…PECs have gained much attention in the past few years because of their potential applications. These can be used as membranes[ 31 – 33 ], for coating on films and fibers[ 34 ], for isolation and fractionation of proteins[ 35 36 ], for isolation of nucleic acid[ 37 – 39 ], for binding pharmaceutical products[ 40 ], as supports for catalyst[ 41 ] and for preparation of microcapsules for drug delivery[ 42 43 ]. Many of the applications are based on the functional properties of the polyelectrolyte.…”

Section: Applications Of Pecsmentioning

confidence: 99%

Polyelectrolyte complexes: A review of their applicability in drug delivery technology

Lankalapalli¹,

2009

View full text Add to dashboard Cite

Over the past several years, great advances have been made towards novel drug delivery systems. The phenomena of interpolymer interactions and formation of polyelectrolyte complexes have been the focus of intensive fundamental and applied research. Interpolyelectrolyte complexes combine unique physicochemical properties with high biocompatibility. Studies have been carried out on many different polymer blends and types. Such combinations may possess unique properties that are different from those of individual component. The present review emphasizes on the applicability of polyelectrolyte complexes in drug delivery technology.

show abstract

Polymer complex from copolymers of acrylonitrile and ionic vinyl benzyl compounds

Cited by 13 publications

References 9 publications

In vitro-in vivo evaluation of xanthan gum and eudragit inter polyelectrolyte complex based sustained release tablets

In vitro-in vivo evaluation of xanthan gum and eudragit inter polyelectrolyte complex based sustained release tablets

Light Scattering and Viscoelasticity in Aqueous Mixtures of Oppositely Charged and Hydrophobically Modified Polyelectrolytes

Polyelectrolyte complexes: A review of their applicability in drug delivery technology

Contact Info

Product

Resources

About