Polymer gel containing N,N′-methylene-bis-acrylamide (BIS) as a single monomer for radiotherapy dosimetry

Rabaeh, Khalid A.; Hammoudeh, Issra’ M.E.; Oglat, Ammar A.; Eyadeh, Molham M.; Abdel-Qader, Ala' J.; Aldweri, Feras M.; Awad, Samer I.

doi:10.1016/j.radphyschem.2021.109522

Cited by 18 publications

(5 citation statements)

References 54 publications

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“…The complex radiation dose response recorded in polymer gels (i.e., degree of polymerization) can be explored in 3D utilizing various modalities such as MRI and optical techniques [ 18 , 19 , 20 ]. The interaction between monomers in the gel after irradiation leads to drops in the mobility of H 2 O molecules and decreases in the relaxation time (T 2 ) values in the MRI technique [ 21 , 22 , 23 , 24 ]. These alterations of the transverse relaxation rate (R 2 = 1/T 2 ) can be measured via NMR relaxometry [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Improved Dose Response of N-(hydroxymethyl)acrylamide Gel Dosimeter with Calcium Chloride for Radiotherapy

Rabaeh

Al-Tarawneh

Eyadeh

et al. 2022

Gels

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The impact of calcium chloride (CaCl2) on the performance of N-(hydroxymethyl)acrylamide (NHMA) polymer gel dosimeter is studied in this article. The dosimeter was exposed to doses of up to 10 Gy with radiation beam-energy of 10 MV and dose-rates of 300 cGy/min. The relaxation rate (R2) parameter was utilized to explore the performance of irradiated NHMAGAT gels. The dose response in terms of R2 increased from 0.29 to 0.63 Gy−1·s−1 with increasing calcium chloride concentration from 0 to 1000 mM. The results show no substantial impact of dose-rates as well as radiation energies on NHMAGAT samples. For the steadiness of irradiated NHMAGAT dosimeters, it was found that there is no apparent variation in R2 (less than ±3%; standard deviation) up to 3 days. The overall uncertainty of the gel dosimeter with calcium chloride is 4.96% (double standard deviation, 95% confidence level).

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Section: Introductionmentioning

confidence: 99%

Improved Dose Response of N-(hydroxymethyl)acrylamide Gel Dosimeter with Calcium Chloride for Radiotherapy

Rabaeh

Al-Tarawneh

Eyadeh

et al. 2022

Gels

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“…These dosimeters have the advantages of simple operation, no need for developing, as well as direct dose visualization; however, these sensing gels have poor tissue-equivalence [24,25]. Radiation polymerization hydrogel sensors need to be scanned by CT to visualize the absorbed doses, which is a complicated and expensive procedure [26,27]. In recent years, fluorescent hydrogel sensing materials have been proposed [28] which have the benefits of long-term storage stability, good tissue equivalency, and simplified, low-cost visualization in comparison to previously mentioned sensing hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Gold-Nanoparticle-Enhanced Radio-Fluorogenic Hydrogel Sensor for Low Radiation Doses in Clinical Radiotherapy

et al. 2022

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Radio-fluorogenic hydrogel dosimeters are urgently needed in radiotherapy for 3D dose verification. However, few hydrogel sensors have been reported at low absorbed doses under 2 Gy which meets the requirements of clinical practice. Here, we report a new type of gold-nanoparticle-enhanced radio-fluorogenic agarose hydrogel with coumarin as the dose-responsive material. An optimal composition of 3 wt% of agarose, 0.5 mM of gold nanoparticles, and 0.1 mM coumarin was selected. The addition of gold nanoparticles enhanced the hydroxyl radicals generated from the radiolysis of water, which can react with coumarin and generate fluorescent 7-hydroxy-coumarin and, eventually, achieve low-dose verification of 0–2.4 Gy with a high linear correlation coefficient. These findings provide an effective method for 3D dose verification, and will inspire the development of other radio-fluorogenic sensing hydrogels as well.

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“…The dosimeter was found stable within a period of 2–120 h after irradiation, and it is independent of dose rate in the range of 50–600 cGy/min and independent of photon beam energy between 6 and 15 MV within 7.5% overall uncertainty. Polymer gels that contain a N,N′-methylene-bis-acrylamide (BIS) crosslinker without the need of adding another radiosensitive monomer have been introduced as a new low-toxic polymer gel dosimeter [ 38 ]. The gel dosimetry accuracy was evaluated by calculating the overall uncertainty and found to be 7.04% (2σ, 95% confidence level).…”

Section: Introductionmentioning

confidence: 99%

HyperArcTM Dosimetric Validation for Multiple Targets Using Ionization Chamber and RT-100 Polymer Gel

Zirone¹,

Bonanno²,

Borzì³

et al. 2022

Gels

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Multiple brain metastases single-isocenter stereotactic radiosurgery (SRS) treatment is increasingly employed in radiotherapy department. Before its use in clinical routine, it is recommended to perform end-to-end tests. In this work, we report the results of five HyperArcTM treatment plans obtained by both ionization chamber (IC) and polymer gel. The end-to-end tests were performed using a water equivalent Mobius Verification PhantomTM (MVP) and a 3D-printed anthropomorphic head phantom PseudoPatient® (PP) (RTsafe P.C., Athens, Greece); 2D and 3D dose distributions were evaluated on the PP phantom using polymer gel (RTsafe). Gels were read by 1.5T magnetic resonance imaging (MRI). Comparison between calculated and measured distributions was performed using gamma index passing rate evaluation by different criteria (5% 2 mm, 3% 2 mm, 5% 1 mm). Mean point dose differences of 1.01% [min −0.77%–max 2.89%] and 0.23% [min 0.01%–max 2.81%] were found in MVP and PP phantoms, respectively. For each target volume, the obtained results in terms of gamma index passing rate show an agreement > 95% with 5% 2 mm and 3% 2 mm criteria for both 2D and 3D distributions. The obtained results confirmed that the use of a single isocenter for multiple lesions reduces the treatment time without compromising accuracy, even in the case of target volumes that are quite distant from the isocenter.

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Polymer gel containing N,N′-methylene-bis-acrylamide (BIS) as a single monomer for radiotherapy dosimetry

Cited by 18 publications

References 54 publications

Improved Dose Response of N-(hydroxymethyl)acrylamide Gel Dosimeter with Calcium Chloride for Radiotherapy

Improved Dose Response of N-(hydroxymethyl)acrylamide Gel Dosimeter with Calcium Chloride for Radiotherapy

Gold-Nanoparticle-Enhanced Radio-Fluorogenic Hydrogel Sensor for Low Radiation Doses in Clinical Radiotherapy

HyperArcTM Dosimetric Validation for Multiple Targets Using Ionization Chamber and RT-100 Polymer Gel

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