Polymer-hydroxyapatite composite versus polymer interference screws in anterior cruciate ligament reconstruction in a large animal model

Hunt, John A.; Callaghan, Jill

doi:10.1007/s00167-008-0528-8

Cited by 42 publications

(31 citation statements)

References 29 publications

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“…131 In addition, Hunt et al demonstrated significantly more new bone formation and decreased inflammatory response when comparing composite HAP/PLLA interference screws to PLLA screws in a large animal ACL reconstruction model. 132 Likewise, PLGA scaffolds coated with CaP resulted in a significantly lower inflammatory response, as determined by histomorphometrical analysis of FBGCs, in comparison to non-coated PLGA scaffolds at 8-weeks post-implantation. 133 Thus, through the incorporation or coating of implants with biomimetic agents, increased bone regeneration and decreased FBR may be attained.…”

Section: Efforts To Mitigate Fbrmentioning

confidence: 91%

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Amini

Wallace

Nukavarapu

2011

J Long Term Eff Med Implants

145

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Presently, orthopedic and oral/maxillofacial implants represent a combined $2.8 billion market, a figure expected to experience significant and continued growth. Although traditional permanent implants have been proved clinically efficacious, they are also associated with several drawbacks, including secondary revision and removal surgeries. Non-permanent, biodegradable implants offer a promising alternative for patients, as they provide temporary support and degrade at a rate matching tissue formation, and thus, eliminate the need for secondary surgeries. These implants have been in clinical use for nearly 25 years, competing directly with, or maybe even exceeding, the performance of permanent implants. The initial implantation of biodegradable materials, as with permanent materials, mounts an acute host inflammatory response. Over time, the implant degradation profile and possible degradation product toxicity mediate long-term biodegradable implant-induced inflammation. However, unlike permanent implants, this inflammation is likely to cease once the material disappears. Implant-mediated inflammation is a critical determinant for implant success. Thus, for the development of a proactive biodegradable implant that has the ability to promote optimal bone regeneration and minimal detrimental inflammation, a thorough understanding of short- and long-term inflammatory events is required. Here, we discuss an array of biodegradable orthopedic implants, their associated short- and long- term inflammatory effects, and methods to mediate these inflammatory events.

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Section: Efforts To Mitigate Fbrmentioning

confidence: 91%

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Amini

Wallace

Nukavarapu

2011

J Long Term Eff Med Implants

145

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“…Also, incorporation of HA into PLLA enhances protein adsorption and increases the compressive modulus in comparison with pure PLLA scaffolds [24] . In one study, mouse fibroblasts cultured on PLLA/HA scaffolds showed a reduction in the inflammatory response compared with pure PLLA [25] . The stress-shielding problem is a result of elastic modulus mismatch between metallic materials and natural bone.…”

Section: Introductionmentioning

confidence: 99%

Effective combination of aligned nanocomposite nanofibers and human unrestricted somatic stem cells for bone tissue engineering

et al. 2011

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Aim: Bioartificial bone tissue engineering is an increasingly popular technique to solve bone defect challenges. This study aimed to investigate the interactions between matrix composition and appropriate cell type, focusing on hydroxyapatite (HA), to achieve a more effective combination for bone regeneration. Methods: Human unrestricted somatic stem cells (USSCs) were isolated from placental cord blood. The cellular and molecular events during the osteo-induction of USSCs were evaluated for 21 d under the following conditions: (1) in basal culture, (2) supplemented with hydroxyapatite nanoparticle (nHA) suspension, and (3) seeded on electrospun aligned nanofibrous poly-ε-caprolactone/poly-L-lactic acid/nHA (PCL/PLLA/nHA) scaffolds. The scaffolds were characterized using scanning electron microscope (SEM), fourier transform infrared spectroscopy (FTIR) and tensile test. Results: Maintenance of USSCs for 21 d in basal or osteogenic culture resulted in significant increase in osteoblast differentiation. With nHA suspension, even soluble osteo-inductive additives were ineffective, probably due to induced apoptosis of the cells. In contrast to the hindrance of proliferation by nHA suspension, the scaffolds improved cell growth. The scaffolds mimic the nanostructure of natural bone matrix with the combination of PLLA/PCL (organic phase) and HA (inorganic phase) offering a favorable surface topography, which was demonstrated to possess suitable properties for supporting USSCs. Quantitative measurement of osteogenic markers, enzymatic activity and mineralization indicated that the scaffolds did not disturb, but enhanced the osteogenic potential of USSCs. Moreover, the alignment of the fibers led to cell orientation during cell growth. Conclusion:The results demonstrated the synergism of PCL/PLLA/nHA nanofibrous scaffolds and USSCs in the augmentation of osteogenic differentiation. Thus, nHA grafted into PCL/PLLA scaffolds can be a suitable choice for bone tissue regeneration.

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“…PLA is used extensively in surgery as suture materials and bone fixation devices; a large number of investigations have been carried out on PLA and its copolymers in biomedical applications for resorbable medical implants [6–8]. Biodegradable polymers like PLA have specific advantages over metallic or ceramic materials in medical applications [9,10]. PLA can be used in the shape of a rod, plate, screw, fiber, sheet, sponge, or beads for bone and tissue engineering, or as microspheres for drug delivery systems [3,11].…”

Section: Introductionmentioning

confidence: 99%

Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament

Beslikas

Gigis

Goulios

et al. 2011

IJMS

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In the present work, the crystallization behavior and in vitro–in vivo hydrolysis rates of PLA absorbable reinforcement ligaments used in orthopaedics for the repair and reinforcement of articulation instabilities were studied. Tensile strength tests showed that this reinforcement ligament has similar mechanical properties to Fascia Latta, which is an allograft sourced from the ilio-tibial band of the human body. The PLA reinforcement ligament is a semicrystalline material with a glass transition temperature around 61 °C and a melting point of ~178 °C. Dynamic crystallization revealed that, although the crystallization rates of the material are slow, they are faster than the often-reported PLA crystallization rates. Mass loss and molecular weight reduction measurements showed that in vitro hydrolysis at 50 °C initially takes place at a slow rate, which gets progressively higher after 30–40 days. As found from SEM micrographs, deterioration of the PLA fibers begins during this time. Furthermore, as found from in vivo hydrolysis in the human body, the PLA reinforcement ligament is fully biocompatible and after 6 months of implantation is completely covered with flesh. However, the observed hydrolysis rate from in vivo studies was slow due to high molecular weight and degree of crystallinity.

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Polymer-hydroxyapatite composite versus polymer interference screws in anterior cruciate ligament reconstruction in a large animal model

Cited by 42 publications

References 29 publications

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Short-Term and Long-Term Effects of Orthopedic Biodegradable Implants

Effective combination of aligned nanocomposite nanofibers and human unrestricted somatic stem cells for bone tissue engineering

Crystallization Study and Comparative in Vitro–in Vivo Hydrolysis of PLA Reinforcement Ligament

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